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Indah Solihah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Antidiabetic Activity Test of Ethanolic Seri Leave’s (Muntingia Calabura L.) Extract in Male Rats Induced by Alloxan Herlina Herlina; Annisa Amriani; Indah Solihah; Rizky Sintya
Science and Technology Indonesia Vol. 3 No. 1 (2018): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (429.13 KB) | DOI: 10.26554/sti.2018.3.1.7-13

Abstract

Antidiabetic activity test of ethanol extract of seri leave (Muntingia calabura L.) rats induced by alloxan has been done. Male wistar albino rats are used as animal models which divided into 6 groups, normal group (aquadest), negative control group (Na CMC 0,5%), positive control group (glibenclamide 0,43 mg/200 gBB), and 1, 2, and 3 treatment groups (ethanol extract of seri leave 65, 130, dan 260 mg/kgBB). Rats blood glucose level after induced intraperitoneally by alloxan 130 mg/kgBB can be stated as diabetes when >200 mg/dL. Preprandial blood glucose levels are measured using DTN-410-K photometer, on day 0, 5, 10, and 15. The average result of AUC0-15 and percentage of decreasing blood glucose level for positive control group are 2732,5 and 37,43%, and 3 treatment groups (65 mg/kgBB, 130 mg/kgBB, and 260 mg/kgBB) 3105 and 28,90%; 2962,5 and 32,16%; 2810 and 35,66%. This point indicated that the ethanol extract of seri leave has an antidiabetic activity and there is no significant difference compared with glibenclamide (p<0,05). Percentage of blood glucose decrease level the third treatment group there is no significant difference compare with positive control group. According to the relation between percentage of blood glucose decrease level with dose, value of ED50 of ethanol extract of seri leave is 692,424 mg/kgBB.
Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil Herlina Herlina; Budi Untari; Indah Solihah; Merie Santia
Science and Technology Indonesia Vol. 4 No. 1 (2019): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (670.916 KB) | DOI: 10.26554/sti.2019.4.1.24-30

Abstract

Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p>0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN TAHONGAI (Kleinhovia hospita L.) MENGGUNAKAN METODE RAT PAW EDEMA Indah Solihah; Herlina; Oktia Charmila
Jurnal Permata Indonesia Volume 8, Nomor 2, November 2017
Publisher : Politeknik Kesehatan Permata Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (672.176 KB)

Abstract

Tahongai (Kleinhovia hospita L.) telah banyak digunakan dalam pengobatan tradisional diIndonesia oleh suku Komering, Sumatera Selatan untuk mengobati penyakit yang berhubungandengan inflamasi, seperti tumor, polip, jerawat, dan nyeri haid. Senyawa aktif yang berhasildiisolasi dari daun tahongai yaitu astragalin, eleutherol, skopoletin, (Arung et al, 2012),kuersetin, rutin, dan kaemferol (Ramesh & Subramanian, 1984). Senyawa flavonoid telah ditelitimemiliki aktivitas antiinflamasi (Middleton,2000). Penelitian ini bertujuan untuk mengetahuiaktivitas antiinflamasi dari ekstrak etanol daun tahongai secara in vivo. Pengujian antiiinflamasidilakukan menggunakan metode rat paw edema pada 25 ekor tikus putih jantan galur Wistaryang dibagi menjadi 5 kelompok. Kelompok I sebagai kontrol negatif diberikan Na CMC 1%,kelompok II diberikan Na diklofenak sebagai kontrol positif, kelompok III, IV dan V diberikanekstrak 250, 500, dan 750 mg/kgBB. Hasil penelitian menunjukkan bahwa pemberian ekstraketanol daun tahongai pada dosis 500 dan 750 mg/kgBB secara oral memiliki aktivitasantiinflamasi yang tidak berbeda signifikan (p >0,05) terhadap kontrol positif. Dosis efektif(ED50) dihitung berdasarkan persen inhibisi rata-rata edema tikus, didapatkan nilai ED50 ekstraketanol daun tahongai sebesar 605,04 mg/kgBB.
Co-Authors Annisa Amriani Budi Untari Herlina Herlina Herlina Merie Santia Oktia Charmila Rizky Sintya