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All Journal Jurnal Sain Veteriner Jurnal Kedokteran Brawijaya YARSI Medical Journal
Sri Murwani
Bagian Mikrobiologi Fakultas Kedokteran UNIBRAW Malang
Medicine & Pharmacology Veterinary

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DIET ATEROGENIK PADA TIKUS PUTIH (Rattus novergicus strain Wistar) SEBAGAI MODEL HEWAN ATEROSKLEROSIS Murwani, Sri; Ali, Mulyohadi; Muliartha, Ketut
Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1301.176 KB) | DOI: 10.21776/ub.jkb.2006.022.01.2

Abstract

Atherosclerosis is still a major health problem, because 20% of death in the world is caused by atherosclerosis diseases like stroke and myocardial infarct. One of animal models that was successful in atherosclerosis research was New Zealand white rabbit. The purpose of this preliminary research was to determine the atherogenic diet ofwhite rats (Rattus novergicus strain Wistar) as animal model of atherosclerosis especially to find fixed composition and time of the atherogenic diet taken.This research used male; 2 months age, 150-200 grams body weight of white rats Rattus novergicus strain Wistar. The rats were divided into5 groups in equal number, 4 rats respectively. Theywere a negative control group without diet treatment and 4 groups as treatment groups which were given hipercholesterol diet. Atherogenic diet composed of PAR-S, wheat flour, cholesterol, cholic acid, pork oil and water. Data were obtained by measuring of blood cholesterol level and foam cell formation.
IDENTIIFKASI PROTEIN IMUNOGENIK CHLAMYDIA PNEUMONIAE TERHADAP SERUM PENDERITA INFARK MIOARD AKUT Murwani, Sri; Hidayati, Dwi Yuni Nur
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.466 KB) | DOI: 10.21776/ub.jkb.2007.023.02.6

Abstract

Chlamydia pneumoniae is human respiratory tract pathogen and recently investigated as pathogen causingatherosclerosis and acute myocardial infarction (AMI). This research was carrier out to detect proteinpattern of C. pneumoniae, and to study it relation to AMI throughdetection of immunogenic protein. Design research  was laboratory observational and analyzed descriptively. The subject was C. pneumoniae. Protein pattern the bacteria was detected by electrophoresis method, and to detect the immunogenic protein was done immunoblotting. Serum was obtained from AMI patients in Saiful Anwar and Lavallette hospitals.  The result showed, protein pattern C. pneumoniae wasprotein with molecular weight 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, 4 kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44,  34 kDa. Non immunogenic proteins were 97, 91, 23, 19, 9, 5 and 4 kDa. Protein 61 kDa react to all of patient’s serum. It was concluded, C. pneumoniae have protein fractions 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, and 4kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44, 34 kDa, and 61 kDa was the  immunodominant protein. The result proved C. pneumoniae as causative agent of atherosclerosis and acute myocardial infarction, in Indonesia particularly. Key words:C. pneumoniae, immunogenic, AMI
EFFECT OF COMBINED THERAPY USING CHLOROQUINE AND VITAMIN C TO THE PERITONEAL MACROPHAGE FUNCTION IN BALB/C STRAIN MICE INFECTED BY Plasmodium berghei Fitri, Loeki Enggar; Suhendro, Wongso; Murwani, Sri; Muliartha, I Ketut Gede; Ali, Mulyohadi
Jurnal Kedokteran Brawijaya Vol 19, No 3 (2003)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1633.38 KB) | DOI: 10.21776/ub.jkb.2003.019.03.2

Abstract

In acute infection, malaria will induce cellular immunity by activating T lymphocytes and macrophages cells. This induction indirectly triggers free radicals production in order to eliminate the parasites from red blood cells, however high concentration of thismolecules can cause vital tissue pathological changes on host. In late phase of malarial infection, there are immunosupression on macrophages activity including antigen presenting and secretion of immunoregulated mediator. It has been anticipated, vitamin C as antioxidant would diminish the side effect of thesefree radicals during malarial infection and increase the immunity. To see the effect of combination chloroquin and vitamin C in hastening the recuperative process by decreasing parasitemia and increasing the phagocytosis function of macrofages during Plasmodium berghei infection. This study has been carried out using 3 groups of BALB/c mice, all group were inoculated with 1x107Plasmodium berghei infected red-blood cells. No drug was given on control group (IK). In experimental group we introduced an oral therapy ofchloroquin for 5 days in 1.4 mg/cc dosage and vitamin C for 7 days in 0.2 mg/cc dosages concurrently with a Plasmodium berghei inoculation (IKC). One group was only given chloroquin at the same dosage and no drug was given at the control group (IK).
STUDI SEROEPIDEMIOLOGIS CHLAMYDIA PNEUMONIAE DAN BEBERAPA MIKROORGANISME YANG DIDUGA MENYEBABKAN INFARK MIOKARD AKUT Murwani, Sri; Ali, Mulyohadi; Muliartha, Ketut; Purwanto, Purwanto; Susilawati, Ida; Nur Aini, Dinda; Yuni, Yuni
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.634 KB) | DOI: 10.33476/jky.v15i1.1002

Abstract

Acute myocardial infarction (AMI) is still a major health problem. Approximately 20% of death in the world was caused by atherosclerotic diseases like stroke, myocardial infarct. Recent studies explain the role of infection in the pathogenicity of AMI. The purpose of this study was to examine seroepidemiological study of Chlamydia pneumoniae infection related to AMI and its occurrence as pathogen burden-infection with other microorganisms. Subjects for this study were patients diagnosed clinically and laboratorically as AMI, from RSUD Saiful Anwar and RS. Lavalette,Malang. Blood samples were collected from each subject and serum was analyzed for IgG antibodies against C. pneumoniae, CMV, H. pylori and S. mutans. Clinical status was analyzed to find IMA conventional risk factors, such as smoking, hypertension, hypercholesterolemia, and diabetes mellitus. The result showed that the average age of these patients were 55 years and men were more common than women. All of these patients were infected by microorganism. Patients with infection and conventional risk factors were 51,9%, infection without conventional risk factors was 48,2%, and conventional risk factors for IMA without infection was 51, 85%. The most common conventional risk factor was smoking (37, 0%). Infection by S. mutans was detected in all patients (100%), C. pneumoniae 92,6%, CMV 92,6%, H. pylori 77,8%; however multiple infections were observed in most of the patients. It was concluded that microorganisms played rolesin the pathogenicity of IMA. It was suggested that the development of IMA might be contributed by single infection as well as multiple infections. However, multiple infections tend to be observed in most of the patients.
Pemberian Ekstrak Etanol Daun Jambu Mete (Anacardium occidentale) dalam Reduksi Kadar IL-6 dan Peningkatan Kadar SOD pada Mencit Fibrosis Hepar yang Diinduksi CCl4 Hutabarat, Mariana Ruth Theresia; Hanifah, Fithria Nisa; Hadijah, Siti; Winarso, Djoko; Murwani, Sri
Jurnal Sain Veteriner Vol 38, No 1 (2020): April
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.618 KB) | DOI: 10.22146/jsv.57361

Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix. The prevalence of liver fibrosis in small animal was reported by 10% of all systemic diseases occured in the United States. One of the toxic materials that cause liver fibrosis is carbon tetrachloride (CCl4). This study aims to determine the preventive effect of ethanol extract of leaves of cashew (Anacardium occidentale) against the production of Interleukin-6 (IL-6) and increase the levels of superoxide dismutase (SOD). Leaves cashew contain of flavonoids which have anti-inflammatory and antioxidant effects. This research is an experimental study, post-test control only design using a completely randomized design. Mice (Mus musculus) were divided into 5 groups, namely the negative control group, positive control group, preventive group dose of 500 mg/kg BW, 1000 mg/kg BW, and 1500 mg/kg BW. Interleukin-6 production is calculated using flowcytometry, while SOD was measured using spectophotometer. Data were statistically analyzed within one way ANOVA (α=0.05) with advanced test Post Hoc Tukey. Conclusions from this research that the preventive use of ethanol extract of leaves of cashew to prevent an increase of IL-6 production and increasing the levels of SOD in mice models of liver fibrosis. Production of IL-6 in group of 1500 mg/kg BW is 2.58%. SOD levels in group of 1500 mg/kg BW is 4.23%. 
Co-Authors Djoko Winarso Dwi Yuni Nur Hidayati Hanifah, Fithria Nisa Hutabarat, Mariana Ruth Theresia I Ketut Gede Muliartha IDA Susilawati, IDA Ketut Muliartha Loeki Enggar Fitri Mulyohadi Ali Nur Aini, Dinda Purwanto Purwanto Siti Hadijah Wongso Suhendro YUNI, YUNI