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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Medik Veteriner ARSHI Veterinary Letters Jurnal Riset Agribisnis dan Peternakan
Dyah Ayu Oktavianie Ardhiana Pratama
Veterinary Study Program, Faculty Of Veterinary, Universitas Brawijaya, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Veterinary

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Trigona sp. Propolis Ethanolic Extract Decreased Chloramphenicol-induced Serum Glutamic Oxaloacetic Transaminase and Alkaline Phosphatase Levels of Rats (Rattus novergicus) Chanif Mahdi; Anna Zukiaturrahmah; Dyah Ayu Oktavianie Ardhiana Pratama; Putranty Widha Nugraheni
Indonesian Journal of Cancer Chemoprevention Vol 9, No 3 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss3pp110-117

Abstract

Liver has an important role in detoxification of toxins such as xenobiotic which could interfere the function of liver. Chloramphenicol is an antibiotic widely used,despite of its toxicity potentials. The enhancement of free radicals in the body could suppress antioxidant activity. Propolis of Trigona sp. has been known to contain very high amount of antioxidants. The enhanced serum glutamic oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) levels in serum is used as marker of liver damage due to the increase of free radicals. The purpose of this study was to observe the effect of Trigona sp. propolis ethanolic extract on SGOT and ALP levels in rats (Rattus novergicus) pretreated by chloramphenicol to induce liver damage. Test animals used for this research were male rats aged 8-12 weeks divided into five treatment groups: negative controlgroup (normal), positive control group (induced by 400 mg/kgBW chloramphenicol), first therapy group, second therapy group, third therapy group induced by chloramphenicol with and propolis extract with the dose of 8 mg, 16 mg, and 24 mg, respectively. Chloramphenicol was injected subcutaneously for 14 days, whereas propolis extract were administered orally for 21 days. The level of SGOT and ALP was determined using spectophotometry. The results showed that propolis extract could reduce levels of SGOT and ALP. Dose of 24 mg/kg was the effective dose to decrease levels of SGOT and ALP significantly (p<0.01). Hence, it may be concluded that the ethanol extract of propolis could be used as herbal therapy in rats model of liver damage.Keywords : ALP, liver, chloramphenicol, propolis, SGOT
The Association of Age and Number of Parturition with Mammary Gland Tumor Case Rate in Mice in Malang Raya Maulidi Robingi Mardiyani Wukirani; Essly Hervianingsih Adha; Sang Ayu Putri Aristya Dewi; Ani Setianingrum; Dyah Ayu Oktavianie Ardhiana Pratama; Andreas Bandang Hardian
Jurnal Medik Veteriner Vol. 5 No. 1 (2022): April
Publisher : Faculty of Veterinary Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol5.iss1.2022.9-15

Abstract

Mammary gland tumours are frequently reported in adult female mice. It broadly affects the productivity and breeding performance of mice in breeding centres. The tumours might occur spontaneously due to internal factors such as genetic mutation and hormonal disturbance, however, external causes such as Mouse Mammary Tumour Virus (MMTV) infection was also reported. This study aimed to prove that age and number of parturition associate with mammary gland tumour case rate in female mice in Malang Raya. Chi-square tests were employed to analyse the association between risk factors and mammary gland tumour case rate in this study. Histopathologic analysis described three subtypes of mammary gland tumours in mice which were adenoma, adenocarcinoma type A and adenocarcinoma type B. Chi-square tests results of tumour case rate toward age and number of parturitions were consecutively 0,004 and 0,0025 which indicated that age and number of parturitions were associated with mammary gland tumours case rate in mice in Malang Raya. The mapping of tumour case distribution visually showed a trend that higher disease proportions were spotted in higher altitude of sampling location. This might relate to the geographical breeding characteristics or temperature which needs further study to explore the association of spatial factors with the mammary tumour incidence in mice.
Potensi Kombinasi Kurkumin dan Vitamin E Terhadap Ekspresi Interleukin-1 (Il-1) dan Cyclooxigenase-2 (Cox-2) pada Ovarium Tikus (Rattus Norvegicus) Model Kanker Mammae Dyah Ayu Oktavianie Ardhiana Pratama; Herawati Herawati; Aulia Firmawati; Putri Dewi; Anna Roosdiana
Jurnal Riset Agribisnis dan Peternakan Vol. 3 No. 1 (2018)
Publisher : Universitas Muhammadiyah Purworejo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.944 KB)

Abstract

Kanker mammae merupakan jenis neoplasma ganas yang menyerang jaringan mammae, yang dapat dipicu oleh agen karsinogenik DMBA (dimethyl benz (α) anthracene). Kanker mammae akibat induksi DMBA mempunyai kemungkinan untuk menyebar ke organ lain seperti ovarium. Peningkatan jumlah ROS secara sistemik dapat menimbulkan kondisi stress oksidatif pada ovarium, hal ini memicu makrofag untuk mengaktivasi sitokin proinflamatori, yaitu IL-1 dan COX-2 untuk menimbulkan reaksi inflamasi. Tujuan penelitian ini adalah untuk mengetahui potensi kombinasi kurkumin dengan vitamin E dalam menurunkan ekspresi IL-1 dan COX-2 pada ovarium tikus model kanker mammae yang diinduksi oleh DMBA. Pembuatan hewan model kanker mammae dilakukan dengan induksi DMBA dosis 10 mg/kg BB dan estrogen dosis 20.000 IU/kg BB. Penelitian ini dibagi dalam 5 kelompok perlakuan yaitu kelompok kontrol negatif (KN), kontrol positif (KP), perlakuan satu (P1) terapi dengan kurkumin 48mg/kg BB dan vitamin E 300 IU/ekor, perlakuan dua (P2) dosis 72mg/kg BB dan 200 IU/ekor, dan perlakuan tiga (P3) dosis 108mg/kg BB dan 100 IU/ekor. Ekspresi IL-1 dan COX-2 diamati dengan Imunohistokimia. Analisis data dilakukan dengan uji ANOVA, karena terdapat perbedaan nyata hasil antar perlakuan, maka dilakukan uji Tukey (α<0,05). Hasil penelitian menunjukkan terapi kombinasi kurkumin dan vitamin E pada tikus kanker mammae mampu menurunkan ekspresi IL-1 sebesar 60% dan COX-2 sebesar 43% secara signifikan dengan dosis efektif kurkumin 108 mg/kg BB dan vitamin E 100 IU/ekor.
Patologi suspect feline viral rhinotracheitis pada kucing Persia Cindy oktati Oktati Kasari; Dyah Ayu Oktavianie Ardhiana Pratama; Albiruni Haryo
ARSHI Veterinary Letters Vol. 6 No. 1 (2022): ARSHI Veterinary Letters - Februari 2022
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.6.1.13-14

Abstract

Feline herpesvirus-1 (FHV-1) atau feline viral rhinotracheitis (FVR) merupakan agen penyakit saluran respirasi atas yang penting pada kucing. Hal ini disebabkan transmisi penyakit yang mudah. Kucing terinfeksi melalui kontak langsung dengan sekreta konjungtival atau oronasal dari kucing yang terinfeksi. Tujuan studi ini yaitu melihat kondisi patologi secara makroskopik dan mikroskopis pada kucing yang diduga terinfeksi virus rhinotracheitis. Organ yang diperiksa antara lain trakea, paru, dan limpa. Perubahan patologi yang terjadi pada organ-organ tersebut yaitu pneumonia interstitial edematous dan emfisema pulmonum, kongesti pada arteri trabecular dan tracheitis hemoragika.
Co-Authors Albiruni Haryo Ani Setianingrum Anna Roosdiana Chanif Mahdi Cindy oktati Oktati Kasari Essly Hervianingsih Adha Firmawati, Aulia Hardian, Andreas Bandang Herawati Herawati Maulidi Robingi Mardiyani Wukirani Putranty Widha Nugraheni Putri Dewi Sang Ayu Putri Aristya Dewi Zukiaturrahmah, Anna