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ANALISIS SENYAWA ALKALOID DAUN TANAMAN JOHAR (Cassia siamea Lmk.) YANG BERPOTENSI SEBAGAI INSEKTISIDA PADA NYAMUK Setiawan, Topan; Aminah, Sitti; Jura, Minarni R.
Jurnal Akademika Kimia Vol 2, No 3 (2013)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Research about alkaloid compound of johar plant leaf (Cassia siamea Lmk.) which potential as insecticide at mosquito. The methods are used is laboratory experiment from johar plant leaf extract. Alkaloid has product from separated extract of johar plant leaf. Maximum wave has product by UV-Vis spectrophotometer is 306 nm. TLC product of johar plant leaf extracts are 2 components (Rf 0.89 and 0.91). TLC product of johar plant leaf alkaloid is 1 component (Rf 0.91). The product of HPLC showed 4 components for johar plant leaf and 2 components for alkaloid. The insecticide force of 25 mosquitos did by third for extract and alkaloid. The products are johar leaf extract have insecticide force for each treatment are 14, 10 and 14 mosquitos although alkaloids are 13, 8 and 2 mosquitos.
Study of Stability and Reactivity of Cyclopolic Acid Compounds and Their Derivatives Using Semi-empirical Methods AM1 and PM3 Arsyad Arsyad; Haniran Majid; Topan Setiawan; Muhammad Adrian Natsir
TECHNO: JURNAL PENELITIAN Vol 10, No 2 (2021): Techno Jurnal Penelitian
Publisher : Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/tjp.v10i2.2949

Abstract

The semiempirical method is a method that can be selected in computational chemistry. This method can be used to study the stability and reactivity of cyclopolic acid compounds and their derivatives. This method is simple method in optimizing a compound in calculating the parameters possessed by the atom. Cyclopolic acid is an organic compound that can be found in corn and beans. Analysis using two methods on HyperChem Professional application are AM1 and PM3. Analysis Result shows that the total energy and gradient of each compound do not have significant differences in calculations. As in the structure of 2-formyl-3-(hydroxymethyl)-6-methoxy-5-methylterephthalic acid has a total energy of -80608.1868567 (kcal/mol) and a gradient of 0.0898817 (kcal/mol/Ang) with the AM1 method and total energy of -74935.9180118 (kcal/mol) and a gradient of 0.0874369 (kcal/mol/Ang) with the PM3 method. The stable structure is in the structure of the 2-formyl-3-(hydroxymethyl)-6-methoxy-5-methylterephthalic acid based on the calculation of the total energy and gradient. Meanwhile, according to the calculation of the difference between LUMO-HOMO, it has different results. Where according to the calculation of the energy difference between LUMO-HOMO, the most stable compound structure is the structure of 2-formyl-3-(hydroxymethyl)-4-isocyano-6-metoxy-5-methylbenzoic acid but is not reactive. Likewise, the 2-formyl-4-hidroxy-3-(hydroxymethyl)-6-methoxy-5-methylbenzoic acid, 2-formyl-3-(hydroxymethyl)-6-methoxy-5-methyl-4-(oxo-λ6-methyl)benzoic acid and 2-formyl-3-(hydroxymethyl)-6-methoxy-5-methylterephthalic acid are reactive but unstable compound structure.
Validitas Media Berbasis Android pada Materi Struktur dan Fungsi Asam Amino dan Protein Topan Setiawan; Fitriana Ibrahim
Orbital: Jurnal Pendidikan Kimia Vol 5 No 2 (2021): Orbital: Jurnal Pendidikan Kimia
Publisher : Chemistry Education Department of Education and Teaching Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/ojpk.v5i2.9343

Abstract

The COVID-19 pandemic has forced major changes in the world of education. The application of social distancing to learning from home makes educators must be more creative in learning. The use of appropriate media in learning is very important to overcome these problems. One of the media used is android-based learning media. This research is continuation research of android application design in the subject of structure and function of amino acids and proteins. This research is limited to media validation. The instrument validation test stated that the instrument was valid with rcount greater than rtable at the number of N = 34 and a significance value of 5%. The reliability test of the validation instrument shows the rcount value of 0.880 and is greater than rtable 0.339 at the number of N = 34 and a significance value of 5%. The score of the questionnaire instrument was 3,196 obtained by averaging the scores from each category. It is in the range of 2.9-3.4 with a high category so that it can be interpreted that the application can be used as a learning media of the structure and function of the molecule.
Development and Implementation of Greater Learning Model Integrated Structured Tasks to Improve Student's Concepts Understanding Nurul Aulia Rahman; Sudir Umar; Topan Setiawan
EduLine: Journal of Education and Learning Innovation Vol. 2 No. 2 (2022)
Publisher : Lembaga Penelitian dan Pengembangan Teknologi dan Rekayasa, Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.452 KB) | DOI: 10.35877/454RI.eduline797

Abstract

This study was conducted at the Chemistry Education Study Program, Faculty of Teacher Training and Education, Khairun University. This study aims to develop the GREATER-2T learning tool and its implementation to students' understanding of concepts in basic chemistry 1 course & teaching and learning strategies of chemistry. The population and sample in this study were all students of the chemistry education study program who programmed chemistry teaching and learning planning courses and chemical research methodology, the odd semester of the 2021/2022 academic year. Sample selection using saturated sampling technique. The method used in this research is research and development ( research and development ). The products to be developed are learning tools in the form of lecture program units (SAP), learning implementation plans (RPP), and teaching materials. The development model used by Plomp consists of 5 stages, namely: 1) initial investigation, (2) design, (3) realization/construction, (4) evaluation and revision, and (5) implementation. The research instruments were in the form of validation sheets for learning tools and teaching materials, student response assessment sheets, and concept mastery assessment instruments. Data analysis used descriptive and inferential analysis, using the SPSS software.
Analisis Pengetahuan Laboratorium Kimia Siswa Kelas XI SMA se Kecamatan Jailolo Niswatun Hasanah; Abdul Rasid Saraha; Topan Setiawan
SAINTIFIK Vol 8 No 1 (2022): Saintifik: Jurnal matematika, sains, dan pembelajarannya.
Publisher : Universitas Sulawesi Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31605/saintifik.v8i1.344

Abstract

Tujuan dari penelitian ini untuk melihat pengetahuan laboratorium siswa kelas XI SMA se kecamatan Jailolo dan melihat perbedaan pengetahuan laboratorium kimia dari masing-masing sekolah SMA di kecamatan Jailolo. Jenis penelitian ini yaitu penelitian deskriptif dengan teknik pengambilan sampel menggunakan cluster sampling pada tahap pertama dan dilanjutkan dengan simple random sampling pada tahap kedua, metode pengumpulan data dengan menggunakan tes tertulis dan penyebaran angket. Hasil dari penelitian ini didapat bahwa pengetahuan laboratorium siswa SMA di kecamatan Jailolo berdasarkan konversi skala lima didapat 4 (17%) siswa dari SMA Negeri 1 Halmahera Barat yang masuk dalam kategori Sangat Tinggi sedangkan untuk SMA Swasta Islam Jailolo dan SMA Swasta Advent Pioneer Akediri tidak ada siswa yang termasuk dalam kategori sangat tinggi yaitu pada skor nilai 27 ke atas dan terdapat perbedaan pengetahuan Laboratorium kimia siswa kelas XI IPA di kecamatan Jailolo karena analisis Kruskall-Wallis mendapat nilai sig. 0,000 sehingga Ho ditolak dan Ha diterima.
Development of Interactive E-Modules Based-Kvisoft Flipbook Maker Pro in Direct Learning on Redox Reaction Materials Nurul Aulia Rahman; Erwinda R. Koroy; Deasy Liestianti; Sudir Umar; Topan Setiawan
EduLine: Journal of Education and Learning Innovation Vol. 2 No. 4 (2022)
Publisher : Lembaga Penelitian dan Pengembangan Teknologi dan Rekayasa, Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (516.885 KB) | DOI: 10.35877/454RI.eduline1233

Abstract

This study aims to develop an Interactive E-Module Based on Kvisoft Flip Book Maker Pro, its implementation of the level of students' understanding of redox reaction material. The interactive e-module referred to in this case is an electronic module that can be viewed through mobile devices and computers offline. The population and samples in this study were all students of class X MAN 1 North Halmahera for the 2021/2022 academic year, which amounted to 44 people and were spread in 2 different classes. Sample selection using saturated sampling techniques. The method used in this research is research and development. The product to be developed is an interactive E-Module based on Kvisoft Flip Book Maker Pro, with other supporting learning tools in the form of a syllabus, learning implementation plan (RPP), and practicum guide. The development model used from Plom consists of 5 stages, namely: 1) preliminary investigation, (2) design, (3) realization / construction, (4) evalusai and revision, (5) implementation. Product effectiveness trials are limited trials in the form of experimental research using the Two-Group Pretest Posttest research design. Research instruments are in the form of E-module validation and practicality sheets, student response assessment questionnaires, and learning outcomes assessment instruments. Data analysis uses descriptive and inferential analysis, using SPSS applications.
PENGARUH MODEL PEMBELAJARAN MIND MAPPING TERHADAP HASIL BELAJAR SISWA PADA MATERI HUKUM-HUKUM DASAR KIMIA KELAS X SEMESTER GENAP DI SMA NEGERI 1 KEPULAUAN SULA Mutiara Yoisangadji; Nurul Aulia Rahman; Topan Setiawan
SAINTIFIK@: Jurnal Pendidikan MIPA Vol 7, No 2 (2022): SAINTIFIK@: Jurnal Pendidikan MIPA EDISI OKTOBER 2022
Publisher : Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (849.588 KB) | DOI: 10.33387/saintifik.v7i2.5501

Abstract

Penelitian ini bertujuan untuk mengetahui: (1) Pengaruh model pembelajaran Mind mapping terhadap hasil belajar siswa kelas X semester genap di SMA Negeri 1 Kepulauan Sula pada materi hukum – hukum dasar kimia (2) Besar pengaruh model pembelajaran Mind mapping terhadap hasil belajar siswa kelas X semester genap di SMA 1 Kepulauan Sula pada materi hukum – hukum dasar kimia. Jenis penelitian ini merupakan penelitian eksperimen dengan desain penelitian two group pretest-posttest. Populasi dalam penelitian ini adalah seluruh siswa kelas X MIPA SMA Negeri 1 Kepulauan Sula dan sampel penelitian adalah siswa kelas X MIPA1 dan X MIPA3 tahun ajaran 2021/2022. Instrumen yang digunakan dalam penelitian ini yaitu instrument validasi untuk instrument tes, instrument observasi dan angket tanggapan siswa terkait model pembelajaran Mind mapping. Hasil uji hipotesis yang diperoleh dalam penelitian ini adalah nilai asyimp sign 2- tailed lebih kecil dari taraf signifikansi 0,05 yaitu 0,000 0,05 maka dapat disimpulkan bahwa: (1) Adanya pengaruh model pembelajaran Mind mapping terhadap hasil belajar siswa kelas X semester genap di SMA Negeri 1 Kepulauan Sula pada materi hukum – hukum dasar kimia (2) Besar pengaruh model pembelajaran Mind mapping terhadap hasil belajar siswa, dengan nilai gain pada kelas eksperimen 0,6 dengan kategori sedang.
Reactivity of Cetophenone and Its Derivatives with Semi-Empirise Methods Parameterizedmodel 6 (PM6) Topan Setiawan; Saras Wati Banapon; Intan Sapsuha; Wahyu Yusup Duwila
EduChemia (Jurnal Kimia dan Pendidikan) Vol 7, No 1 (2022)
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30870/educhemia.v7i1.11844

Abstract

Cetophenone is used as an intermediate in the synthesis of flavones. In industry, Cetophenone is obtained as a by-product of the oxidation of ethyl benzene. The method used for modeling Cetophenone derivatives is a semi-empirical method using (PM6). The cetophenone derivative which has a larger energy difference is found in the compound 2-aceyiylisophyhaloitrile. The highest value of electronegativity and chemical hardness was found in the compound 2-aceyiylisophyhaloitrile and the greatest potential energy value was found in the compound 2-aceyiylisophyhaloitrile.
Computational Chemistry: QSAR of Dental Disease Causing Streptococcus mutans Using Eugenol Derivative Compounds from Clove Essential Oil Muliadi Muliadi; Topan Setiawan; Ike Dwi Setiani; Nur Asbirayani Limatahu; Deasy Liestianty
TECHNO: JURNAL PENELITIAN Vol 12, No 1 (2023): TECHNO JURNAL PENELITIAN
Publisher : Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/tjp.v12i1.5793

Abstract

Research on the activity of eugenol derived compounds as antimicrobials using the qualitative structure-activity relationship (QSAR) model has been conducted. Molecular structure modeling was executed computationally using the ChemDraw Ultra 12.0 program package. Geometry optimization was performed using AM1 semi-empirical method to stabilize structure with the least energy level. Calculations of hydrophobic, electronic, and steric descriptors were done using Gaussian-09 and Marvin Sketch 64 softwares. Statistical calculations was conducted through multiple linear regression method using the IBM SPSS 25 program. Statistical analysis was carried out based on the statistical requirements of several equation models so that the best equation model was obtained. The analysis with the QSAR equation model obtained that the model 1 equation presented the best results.
STUDI KOMPUTASI KOMPLEKS 1,10-FENANTROLIN DENGAN LOGAM Fe, Cu, Co, Ni dan Zn MENGGUNAKAN METODE DENSITY FUNCTIONAL THEORY (DFT) Fahria Salamat; Muliadi Muliadi; Topan Setiawan
SAINTIFIK@: Jurnal Pendidikan MIPA Vol 8, No 1 (2023): SAINTIFIK@: Jurnal Pendidikan MIPA EDISI MARET 2023
Publisher : Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/saintifik.v8i1.6217

Abstract

Penelitian kimia komputasi dilakukan untuk mengetahui pemodelan struktur kompleks 1,10-fenantrolin dengan logam Fe, Cu, Co, Ni, Zn menggunakan metode DFT dan untuk  mengetahui aktivitas kompleks 1,10-fenantroline dengan logam Fe, Cu, Co, Ni dan Zn pemodelan struktur telah dilakukan secara komputasi dengan menggunakan software ChemDraW Ultra 12.0  dan GaussView dengan basis set B3LYP/6-31G. Parameter yang diperoleh dari hasil optimasi adalah EHOMO, ELUMO, dengan energi total. Dari nilai EHOMO dan ELUMO yang diperoleh kemudian dihitung nilai energy Gap (∆E),potensial ionisasi(I), afinitas elektron(A), elektronegativitas (x),hardness (ɳ), dan softness ( ). Perhitungan secara komputasi secara kimia menunjukan bahwa memodelkaan struktur Kompleks 1,10 Fenantrolin menggunakan metode DFT (Density Finctional Theory) Nilai energi total untuk masing–masing Kompleks 1,10 Fenantrolin adalah Fe-Phen :115.272 kcal/mol, Cu-Phen: 114.711 kcal/mol, Co-Phen: 119,192, kcal/mol Ni-Phen:113,641 kcal/mol:Zn-Phen : 123.99 kcal/mol.