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All Journal VALENSI Journal of Mathematical and Fundamental Sciences Indonesian Journal of Chemistry Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Ismiarni Komala
Pharmacy Department Faculty Of Health Sciences Universitas Islam Negeri Syarif Hidayatullah Jakarta
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Mathematics Medicine & Pharmacology Physics Public Health

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Journal : VALENSI

 1 
Direct Amidation of ethyl p-methoxycinnamate to Produce N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide Ismiarni Komala; Supandi Supandi; Muhammad Mirza Hardiansyah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (469.902 KB) | DOI: 10.15408/jkv.v4i1.7300

Abstract

Ethyl p-methoxycinnamate (EPMC) (1) is found as a major natural ester in the rhizome of Kaempferia galanga (kencur) and has been known to have various pharmacological activities. The previous study has reported the synthesis of N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide (2) by using microwave-assisted direct amidation of EPMC (1) with diethanolamine. In this research, we attempt to synthesize of 2 by using a conventional direct amidation of EPMC (1) with diethanolamine. The reaction was conducted without adding any coupling reagents or catalyst. Structure of the synthetic product was determined by using analysis of GC-MS, IR, and 1H-NMR spectroscopic data and then compared to the previously reported.DOI:http://dx.doi.org/10.15408/jkv.v4i1.7300
Cytotoxic Activity of the Indonesian Fern Angiopteris angustifolia C. Presl and Liverwort Mastigophora diclados (Birs. ex Web) Nees Against Breast Cancer Cell Lines (MCF-7) Ismiarni Komala; Stevani Sitorus; Fitri Ratna Dewi; Nurmeilis Nurmeilis; Laifa Annisa Hendarmin
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 1, May 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i1.22645

Abstract

Breast cancer is the most frequent cancer among women worldwide, and it is also the main cause of death from cancer. Fern Angiopteris angustifolia C. Presl and Liverwort Mastigophora diclados (Birs.ex Web) Nees are the plants that grow in Indonesia that are limited explored for their phytochemical and biological activity. This study aims to evaluate the cytotoxic effect of ethanolic extracts leaves of A. angustifolia and M. diclados against breast cancer cell lines (MCF-7). The MTT assay was used to determine cytotoxic activity, which revealed that the ethanol extract of A. Angustifolia and M. diclados exhibited cytotoxic activity with an IC50 value of 121.8 ± 13.3 and 29.2 ±1.4 µg /mL, respectively.
Co-Authors Deani Nurul Mubarika Eka Putri Fitri Ratna Dewi Ghilman Dharmawan Laifa Annisa Hendarmin Mida Fahmi Moethia Moethia Muhamad Beny Setiawan Muhamad Beny Setiawan Muhammad Fikry Awaludin Muhammad Mirza Hardiansyah Muhammad Reza Nelly Suryani Noni Tri Utami Nurhasni Nurhasni Nurkhayati Putri Indriyani Nurkhyati Putri Indriyani Nurmeilis Nurmeilis Ofa Suzanti Betha Ofa Suzanti Betha Putri Hayati Nufus Stevani Sitorus Supandi Supandi Supandi Supandi Supandi Supandi Syarifatul Mufidah Yardi Yardi Yardi Yardi