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All Journal Jurnal NERS Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Molekul: Jurnal Ilmiah Kimia Journal of Bionursing Riset Informasi Kesehatan

Saryono Saryono

Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman Purwokerto

Author-ID : 3291085

Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Articles

The Effect of Orlistat, Green Coffee Bean Extract, and Its Combinations on Lipid Profi le and Adiponectin Levels Joko Setyono; Dwi Adi Nugroho; Mustofa Mustofa; Saryono Saryono
Jurnal Ners Vol. 9 No. 1 (2014): April 2014
Publisher : Universitas Airlangga

Introduction: Obesity prevalence is estimated increases, reached 19.1% of the population aged 15 years and over. This study aimed to determine the differences of the anti- obesity effect of orlistat, an extract of green coffee beans (Coffea canephora robusta), and its combination to the adiponectin levels and lipid profile.Method: This research was true experimental post -test only with control group design with completely randomized design (CRD). Experimental animals (Rattus novergicus) were divided into 6 group, group 1 ( negative control ), group 2 ( positive control ), group 3 was group of obese rats fed orlistat dose of 15.9 mg/kg, group 4 was the group of obese rats were fed ethanol extract of green coffee beans dose of 400 mg/kg, group 5 was the group of obese rats were given water extract of green coffee beans dose of 400 mg/kg, and group 6 was group of obese rats were fed a combination of orlistat dose of 15.9 mg/kg and ethanol extract of green coffee beans at a dose of 400 mg/kg. Lipid profi les and adiponectin levels were measured with a spectrophotometer at 500nm absorbance. The data were analyzed by one-way ANOVA, and then post hoc Least Significant Difference (LSD) with α = 0.05.Results: Ethanol extract of green coffee is more effi cient in lowering LDL cholesterol, increasing HDL cholesterol, and lowering the total cholesterol levels on HFD diet-induced mice, but there was no difference in lowering triglycerides . The combination of ethanol extract of green coffee with orlistat showedthe increasing of adiponectin levels were highest than the other treatment groups.Conclusion: The ethanol extract of green coffee readily diffuses through the digestive tract epithelium. Green coffee contains chlorogenic acid active compounds that can increase the body’s metabolism, increase fatty acid oxidation, reduce levels of triglycerides in the liver, and working to inhibit lipase and amylase pancreaticenzymes. In addition to chlorogenic acid, polyphenol content in coffee is also potentially reduce visceral fat accumulation. Preparations extract by ethanol allows the absorption process is done effi ciently and quickly.

Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium Hernayanti Hernayanti; Sri Lestari; Saryono Saryono; Puji Lestari
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Cadmium is a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2

Potensi Jus Buah Pepaya (Carica Papaya L.) Mencegah Nefrotoksisitas pada Tikus Wistar yang Terpapar Pb Asetat Devi Etivia Purlinda; Sorta Basar Ida Simanjuntak; Saryono Saryono
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 37, No 2 (2020)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Lead is a heavy metal with hazardous toxicity causing dysfunction, especially the kidneys as excretion organs. Pb pollution in Indonesia is mostly derived from transportation emissions such as Tetraetillead, which can change into trietillead, a free radical that can reduce endogenous enzyme activity, one of which is SOD pollution. (Superoxide dismutase) which is in various organs, especially the kidneys. A decrease in SOD activity in the kidneys indicates oxidative stress because the enzyme is unable against superoxide anions and causes renal glomerular damage. Kidney damage can increase serum creatinine levels. Papaya juice contains flavonoids, vitamins C, E, and beta-carotene can prevent nephrotoxicity of Pb. The study aimed to obtain the best dose of papaya juice on the SOD activity of Wistar rats kidney tissue and serum creatinine level that exposed by lead acetate. The experiment was conducted experimentally with Completely Randomized Design, which was divided into 6 treatments, P1, P2, P3, of papaya juice, Lead ace with dose: 3.6; 7.2; 14.4 g / 200g of weight and exposed to Pb acetate 50 mg/kg weight. Treatment P4 (rats were given vitamin E 400 IU/kg weight and exposure to Pb acetate 50 mg/kg weight), P5 (rat exposed Pb acetate 50 mg/kg weight), P6 (normal mice) for 28 days. The results showed that papaya juice was the best dose of 14.4 g / 200g weight because the SOD activity of renal tissue was increased, and serum creatinine level decreased significantly. The conclusion is papaya juice can be used to prevent Pb acetate nephrotoxicity.

Maternal and paternal Age and Risk of Autism Spectrum Disorder (ASD) in Banyumas District, Central Java, Indonesia Desiyani Nani; Saryono Saryono; Arif Imam Hidayat; Dyla Annisa Putri; Lantip Rujito
Journal of Bionursing Vol 2 No 2 (2020): Journal Of Bionursing
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Introduction: The prevalence of autism spectrum disorders has increased in the last three decades. The genetic etiological component of ASD is quite strong and complex. Although genetic factors clearly contribute to ASD risk, environmental, prenatal and post-natal factors are also involved. Father's age and mother's age at the conception of children contribute to the occurrence of autism spectrum disorders in children.Objective: To explore the association between maternal and paternal age and risk of autis, spectrum disorders (ASD) in Banyumas district, Central Java, IndonesiaMethods: An analytical study with case control approach was conducted. This study used case control method that include 43 children with ASD as case group and 189 normal children as control group. Consecutive cases were selected over 4 months, with every weekend allocated to visit the school of children with special needs. Controls were selected from normal children who came with their parents and were also visited by our team at local schools, until the required sample size was reached.Results: This study showed that paternal and maternal age at conception onset were not associate with the occurence of asutism spectrum disorders in children based on the statistical annalyzes in every range of paternal and maternal age results p value > 0,05.Conclusion: Paternal and maternal age were not related with the occurence of autism spectrum disorders

Kesehatan mental masyarakat selama pandemi covid-19: Literatur review Aan Febriani; Yollanda Ardhitya Putri; Sharah Ayuni; Saryono Saryono
Riset Informasi Kesehatan Vol 10 No 1 (2021)
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Latar Belakang: Pandemi Covid-19 berpengaruh terhadap perubahan rasa khawatir, takut, panik, tertekan, dan depresi pada kalangan masyarakat. Tujuan dari penulisan ini yaitu mengetahui tingkat kesehatan mental masyarakat akibat pandemi Covid-19. Metode: yang digunakan berupa pencarian database pada Science Direct, PubMed, dan Google Scholar dengan kata kunci Covid-19, kesehatan mental pada masyarakat dan pandemi. Systematic review ini menggunakan 16 artikel dengan kriteria yaitu terbit pada tahun 2020-2021 dengan naskah lengkap, berbahasa Indonesia dan bahasa Inggris. Hasil: penelitian menunjukan bahwa terdapat perubahan kesehatan mental masyarakat akibat pandemi Covid-19. Masyarakat berisiko tinggi terkena depresi akibat pemberlakuan pembatasan fisik, pembatasan sosial dan karantina. Kesimpulan: Penatalaksanaan pandemi covid-19 hendaknya memperhatikan aspek kesehatan mental, sehingga kebutuhan manusia secara holistik terpenuhi.

Co-Authors Aan Febriani Arif Imam Hidayat Desiyani Nani Devi Etivia Purlinda Dwi Adi Nugroho Dyla Annisa Putri Hernayanti Hernayanti Joko Setyono Lantip Rujito Mustofa Mustofa Puji Lestari Sharah Ayuni Sorta Basar Ida Simanjuntak Sri Lestari Yollanda Ardhitya Putri

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