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All Journal Jurnal NERS Herb-Medicine Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia Mandala of Health : A Scientific Journal

Eman Sutrisna

Jenderal Soedirman University

Author-ID : 3291407

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Articles

A Comparative Study of the Effects of Vibration and Electrical Stimulation Therapies on the Acceleration of Wound Healing in Diabetic Ulcers Yunita Sari; S. Saryono; Eman Sutrisna; H. Hartono
Jurnal Ners Vol. 12 No. 2 (2017): October 2017
Publisher : Universitas Airlangga

Introduction: Diabetic ulcers accompanied by ischemia is difficult to treat. Such ulcers require therapy that can improve the blood flow. Previous studies have revealed that two therapies could improve blood flow and accelerate the healing of diabetic ulcers; vibration and electrical stimulation (ES). However, it is unknown which of these two therapies is best at accelerating wound healing in diabetic ulcers. The purpose of this study was to compare both therapies in relation to accelerating the wound healing of diabetic ulcers.Methods: This study was an experimental study involving diabetic rats. The rats were divided into two groups: vibration and ES. Vibration and ES were applied for 10 minutes per day for 7 days. Wound size, inflammation, intensity of fibroblast infiltration, area of necrosis and degree of re-epithelialisation were compared. The difference in wound size was analysed using an independent t-test, while the histological data were analysed using a Mann-Whitney U-test.Results: On day 5 onwards, there was a thin slough in the ES group which was not present in the vibration group. Day 4 onwards and the wound size was significantly smaller in the vibration group than in the ES group. The intensity of inflammation was significantly less, and the degree of fibroblast infiltration was significantly higher in the vibration group compared with the ES group. Re-epithelialisation was more advanced in the vibration group than the ES group.Conclusion: Our study revealed that wound healing in diabetic ulcers following vibration was better than after ES. We suggest that nurses should use vibration rather than ES in clinical settings.

Comparison of the Effect of Ethanol Extracts of Phaleria macrocarpa (scheff.Boerl) Fruit and Metformin on the Kidney Function of Hyperglycaemic Rat Models Eman Sutrisna; Nur Signa Aini Gumilas; Mus topa; Evy Sulistyoningrum
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 3, No 2 (2020): Herb-Medicine Journal Juli 2020
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v3i2.6656

Diabetes mellitus is a disease that often causes diabetic nephropathy complications due to persistent hyperglycaemia. Phaleria macrocarpa (scheff. Boerl) is one of the plants that has been widely used in the treatment of diabetes mellitus, but its effect on the risk of diabetic nephropathy is still unknown. A dose of 300mg / 200gbb / day is known as an effective dose that can significantly reduce blood sugar levels in diabetic rat. The Streptozotocin Effect (STZ) causes damage to the pancreas and causes hyperglycaemia. This study aims to compare the effect of Phaleria macrocarpa (scheff. Boerl) fruit extracts on urea and creatinine levels as a parameter of kidney function in hyperglycaemic mouse models. The study was carried out experimentally using the post-test only with control group design. Fifteen white rats were divided into 3 groups. All rats were induced with 40 mg / 200gbb of Streptozotocin (STZ) to experience hyperglycaemia. Group I as negative control was given aquades. Group II was given ethanol extract of Phaleria macrocarpa (scheff. Boerl) with a dose of 300 mg / 200gbw / day. Group III was given Metformin at a dose of 150 mg / 200gbw / day. On the 22nd day of treatment, blood specimens were taken for examination of urea and creatinine levels. The research data were statistically analyzed with α <0.05; CI95%. The mean of urea levels in Group I (79.80 ± 25.09 mg / dl), II (76.00 ± 22.59 mg / dl and III (59.60 ± 6.35 mg / dl). Kruskal-Wallis test results showed no significant difference in urea levels between treatment groups (p value = 0.273; CI95%). The mean of creatinine levels in Group I (0.68 ± 0.07 mg / dl), II (0.63 ± 0.14 md / dL) and III (0.98 ± 0.25 mg / dL). One Way Anova and Post hoc test results showed a significant difference in mean creatinine levels between Groups I and III (p = 0.014; 95% CI) and II with III ( p value = 0.006; CI95%). the results of this study can be concluded that the extract of Phaleria macrocarpa (scheff. Boerl) fruit flesh at a dose of 300 mg / 200gbb has better effectiveness than metformin dose 150 mg / 200gbb in repairing the kidney function of hyperglycaemia rats.

Sub-chronic hepatotoxicity test of Plantago mayor L. extract Eman Sutrisna; Setia Wati; Farissa Utami; Rahayu Nurmalia Fauziah; Dara AisyahRahayu Abdurrachman; Ika Murti Harini; Thianti Silviningrum
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

The aim of this study was to examine hepatotoxicity of Plantago mayor L. extract on rat by using effective dosage. By experimental study and post test only with control group design. 15 rats (Rattus norvegicus) were divided in to 3 group. Group A as a natural control was given aquades. Group B and C were given extract of Plantago major L. 50mg, and 100mg/200g BW rat/day per oral. Liver function was determined with measurement of Aspartate aminotransferase (AST) level, Alanine aminotransferase (ALT), total bilirubin, and histopathological feature of liver. Blood sampling and Liver organ were taken after 28 days of intervention. The average of AST levels, ALT and total bilirubin among groups A, B and C were AST levels (145.40±52.92, 129.00±34.89, and 115.60±13.24 U/l), ALT (76.40±18.87, 83.20±18.71, and 61.00±8.45 U/l) and total bilirubin (0.56±0.03, 0.77±0.22, and 0.58±0.08 mg/dL). Statistical analysis showed that there were not significantly differences of AST levels (p=0,63; CI95%), ALT (p=0,47; CI95%) and total bilirubin (p=0,0,09; CI95%) between the groups. In histopathological features, the average Scheuer score between groups A, B and C is 1.79 ± 0.74, 3.30 ± 0.66 and 2.84 ± 0.77. There is a significant difference in Scheuer scores between the groups (p=0,005; CI95%) that show that there is a difference in the effect of giving extract of Plantago major L. to hepatocyte cells leading to a piecemeal necrosis. This study can be concluded that in effective dosage, Plantago major L. extract able to induce hepatocytes injury although it cannot cause liver disfunction yet.

The Comparative Effectiveness of Phaleria macrocarpa (Scheff.) Boerl. Pericarp Ethanol Extract and Metformin in Reducing Blood Sugar Levels and Ameliorating the Langerhans Islets Degeneration in Diabetic Rat Models Eman Sutrisna; Qurrotu Aini; Ika Murti Harini; Nur Signa Aini Gumilas; Mustofa Mustofa; Evy Sulistyoningrum
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.6526

Phaleria macrocarpa (Scheff.) Boerl. has been widely used in the treatment of diabetes mellitus but its effectiveness is still inconclusive so it needs to be compared with standard drugs such as metformin. This study aims to analyze the effects of P. macrocarpa fruit extracts on blood sugar levels and the repairing of the pancreatic Langerhans islets of diabetic rat models. The study was conducted experimentally by pre and post-test design with a control group. Thirty white rats were divided into 6 groups. All rats were treated with 40 mg/200 g BW of streptozotocin (STZ) to induce hyperglycemia, except group I. Group II as a negative control was given with aquadest. Group III, IV, and V were given with ethanol extract of P. macrocarpa pericarps at doses of 200, 250, and 300 mg/200 g BW/day, respectively. Group VI was given with metformin at a dose of 150 mg/200 g BW/day. On the 22nd day of treatment, blood specimens were taken for examination of fasting blood sugar levels and pancreatic organs were analyzed for histopathological examination of the islets of pancreatic Langerhans. The data were statistically analyzed with α<0.05; CI95%. Paired sample t-test results showed a significant decrease in blood sugar levels before and after treatment in group V (p-value=0.048). One way anova and post hoc Least Significant Difference (LSD) test results showed a significant difference in mean blood sugar levels after the final treatment between groups I and II (p-value=0.013), I and III (p-value=0.004), I and IV (p-value=0.002), I and VI (p-value=0.000), II and VI (p-value=0.031), and V with VI (p-value=0.005); one way anova and post hoc LSD test results showed a significant difference in the mean area of islets of pancreatic Langerhans between group I and all treatment groups (p-value=0.000), II with V and VI (p-value=0.000 and 0.009), III with V and VI (p-value=0.000 and 0.001), and IV with V (p-value=0.003). It can be concluded that the extract of P. macrocarpa pericarps showed a hypoglycemic effect and repaired the damage in Langerhans islets of STZ-induced rat in a dose-dependent manner.

THE INFORMATION ON STATUS OF ANTIBIOTIC RESISTANCE CHANGING THE PERCEPTION AND ATTITUDES OF WISELY ANTIBIOTIC USE IN BANYUMAS DISTRICT COMMUNITIES Rahmawati Wulansari; Diyah Woro Dwi Lestari; Dwi Utami Anjarwati; Eman Sutrisna
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

The wise use of antibiotics in the Banyumas community is quite alarming. Most of them still buy antibiotics without a doctor's prescription, buy half a prescription and consume antibiotics without finishing it. Good enough knowledge about the dangers of using antibiotics unwisely has not formed a correct perception and attittude of antibiotic use. This study aims to evaluate changes in people's perceptions and attitudes about antibiotic use after being given information related to their resistance status . This research was conducted qualitatively on 10 informants. Retrieval of data through focus group discussion techniques is done before and after providing resistance status information. The results showed that before giving information, perceptions and attitudes towards the use of antibiotics most (80%) of informants were not correct despite having a good level of knowledge. Changes in perceptions and attitudes about the right pattern of antibiotic use wisely occur after being given information about the status of antibiotic resistance they experience. This study can be concluded that the provision of information on the results of the examination of resistance status has a positive effect causing the changing in perception and the right attitude regarding the use of antibiotics wisely in the Banyumas community

Co-Authors Dara AisyahRahayu Abdurrachman Diyah Woro Dwi Lestari Dwi Utami Anjarwati Evy Sulistyoningrum Farissa Utami H. Hartono Ika Murti Harini Ika Murti Harini Mus topa Mustofa Mustofa Nur Signa Aini Gumilas Qurrotu Aini Rahayu Nurmalia Fauziah Rahmawati Wulansari S. Saryono Sari, Yunita Setia Wati Thianti Silviningrum

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