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All Journal PHARMACON Jurnal Ilmiah Manuntung Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Michrun Nisa
Akademi Farmasi Kebangsaan Makassar, Jl. Perintis Kemerdekaan Km 13 , Makassar 91022
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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MIKROENKAPSULASI EKSTRAK BUAH BUNI SEBAGAI FOOD SAFETY COLOURING Syamsinar, Syamsinar; Saputri, Nawalu; Risnayanti, Risnayanti; Nisa, Michrun
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 1, No 2 (2018)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.689 KB) | DOI: 10.35799/pmj.1.2.2018.21654

Abstract

MIKROENKAPSULASI EKSTRAK BUAH BUNI SEBAGAI FOOD SAFETY COLOURINGSyamsinar1), Nawalu Saputri1), Risnayanti1), Michrun Nisa1)1)Akademi Farmasi Kebangsaan MakassarJln. Perintis Kemerdekaan KM 13,Daya,Makassar 90242Email : mnmichrunnisa84@gmail.comABSTRACTDyes in food can increase consumer acceptance of a product, but many synthetic dyes can cause damage to body organs if consumed continuously. Therefore the use of natural ingredients as food coloring needs to be developed. Anthocyanins in Bunny fruits are dyes that can be used as an alternative to synthetic dyes that are safe for health. In this study 3 formulas were made with extract concentrations of 1%, 2% and 3% using 10% maltodextrin. The lack of anthocyanin stability is formulated into microencapsulation which can provide protection against anthocyanins. The resulting micrograph has almost the same color characteristics as the Buni fruit, which is red to purple. The best stability of microcapsules can be seen in formulas with 1% extract concentration, absorption efficiency value is 78.26%, after SEM analysis a uniform pore microstructure is obtained compared to other formulas.Key Words : Anthocyanins, microencapsulation, buni fruits, frezee drying, maltodextrinABSTRAKPewarna dalam makanan dapat meningkatkan penerimaan konsumen terhadap suatu produk, namun banyak pewarna sintesis dapat menyebabkan kerusakan organ tubuh jika dikonsumsi terus menerus. Oleh sebab itu pemanfaatan bahan alami sebagai pewarna makanan perlu dikembangkan. Antosianin dalam buah Buni merupakan zat warna yang dapat dijadikan sebagai alternatif pengganti pewarna sintetis yang aman bagi kesehatan. Pada penelitian ini dibuat 3 formula dengan konsentrasi ekstrak 1 %, 2 % dan 3 % dengan menggunakan maltodekstrin 10 %. Kurangnya stabilitas antosianin maka diformulasi kedalam bentuk mikroenkapsulasi yang dapat memberikan perlindungan pada antosianin. Mikrograf yang dihasilkan memiliki karakteristik warna yang hampir sama dengan buah Buni yaitu berwarna merah hingga ungu. Kestabilan dari mikrokapsul yang paling baik dapat dilihat pada formula dengan konsentrasi ekstrak 1 %, nilai efisiensi penyerapan sebesar 78,26%, setelah analisis SEM diperoleh bentuk mikrostruktur pori yang seragam dibandingkan dengan formula yang lain. Kata kunci : antosianin, mikroenkapsulasi, buah Buni, frezee drying, maltodekstrin 
EVALUASI TINGKAT KEPATUHAN PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN PENYAKIT GINJAL KRONIK LANJUT USIA Fajriansyah, Fajriansyah; Nisa, Michrun
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.548 KB)

Abstract

Chronic Kidney Disease (CKD) is a condition of kidney damage that occurs for 3 months or more in the form of structural or functional abnormalities of the kidney with or without decrease in Glomerular Filtration Rate which manifests as a pathological disorder. Treatment of CKD is closely related to medication adherence that determines a successful treatment, but patient treatment adherence is often low especially in regularity for drug use. This study aims to evaluate the level of adherence to the use of CKD patient drug at the General Hospital of Education Hasanuddin University. The research design is descriptive analysis with Cross Sectional. The data were collected by using questionnaires containing questions that led to patient characteristics, medication adherence, and factors affecting drug use. Measurement of adherence used is Modified Morisky Scale (MMS) which then analyzed using Case Management Adherence Guidelines (CMAG) against 45 subjects. The result of the research is the level of patient compliance based on quadrant level 1 as many as 8 patients (17,78%), quadrant level 2 as many as 8 patient (17,78%), level 3 quadrant 17 patient (37,77%), and quadrant level 4 of 12 patients (26.66%).
EFEK BIOLARVASIDA NYAMUK Aedes aegypti DARI GRANUL EKSTRAK DAUN JERUK NIPIS (Citrus aurantifolia) Mangampa, Yunita; Nisa, Michrun; Fahimah, Nurul; Rannu, Sriwanti Lisu; Anugrawan, Muh; Doa, Febi Rofina
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.34 KB)

Abstract

Dengue Haemorrhagic Fever (DHF) is still one of the problems in Indonesia. Natural materials that has the property of killing the mosquito vector one of them is a lime leaf. lime leaf extract contains limonoids compounds that serve as larvacide.Tujuan of this research is to make granule extract lime leaf (Citrus aurantifolia) which has the ability as a mosquito killer biolarvacide. This type of research is a laboratory experiment. The population in this study were all three instars of Aedes aegypti larvae aged 3-4 days. The results showed that there was granule effect of lime leaf extract (Citrus aurantifolia) to the death of Aedes aegypti mosquito larvae. The granule concentration of lime leaf extract (Citrus aurantifolia) which is effective in killing Aedes aegypti mosquito larvae is 15% extract concentration formulated in granule form with percent mortality of 76.7% larvae.
FORMULASI PATCH KOSMETIK LENDIR BEKICOT (Achatina fulica) DENGAN POLIMER KITOSAN DAN BERBAGAI VARIASI AMILUM Nisa, Michrun; Nuraisyah, Andi; Yusuf, Nurul Arfiyanti; K, Nurul Alifah
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.704 KB) | DOI: 10.51352/jim.v2i2.71

Abstract

The research on cosmetic patch formulation containing snail slime with a variety starch was aimed to determine the type of starch that could produce a patch preparation with a good physical characteristic had been conducted. Cosmetic patch formulation of snail slime was using combination of chitosan and starch polymers such as corn, potato and tapioca starch. The method was used the solvent evaporation technique. The evaluation of patches include weight uniformity, folding endurance, thickness, moisture content, moisture uptake and stability of the patch. The combination of chitosan and starch polymers produced patches that had pH 5 with color uniformity, smoothness of surface and easily removed from the mold. The results showed that patches containing tapioca starch gave weight uniformity that did not much different on each replication that was 0,568 ± 0,03. Patches containing corn starch provided thickness values on each replication did not much different from 0,16± 0,01. Patches containing potato and tapioca starch produced patches that was accordance with the standard parameter of folding endurance was more than 200 times. Patches containing corn and tapioca starch producing patches accordance with the standard parameter of moisture content were less than 10 %. Patches containing potato starch gave patch a high moisture uptake that was 8,2%. The combination of chitosan and tapioca strach as polymers produced patch preparation with a good characteristic on the formulation of snail slime cosmetic patch.
FORMULASI GLIBENKLAMID DENGAN METODE SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) DAN UJI IN-VITRO DISOLUSI Nisa, Michrun
PHARMACON Vol 5, No 1 (2016): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.5.2016.11234

Abstract

FORMULASI GLIBENKLAMID DENGAN METODE SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) DAN UJI IN-VITRO DISOLUSI   Michrun Nisa1), Abdul Halim Umar1), Aisyah Fatmawati2) 1)Akademi Farmasi Kebangsaan Makassar 1)Fakultas Farmasi Universitas Hasanudin Makassar   ABSTRACT   Glibenclamide formulation has been research by the method of  Self Emulsifying Drug Delivery Systems  ( SEDDS ) and studies  in-  vitro  dissolution . This study aims to improve the dissolution rate of glibenclamide with  solid self-  emulsifying system  ( SSE ).  Solid self  -  emulsifying  process using the method of adsorption into the  solid carrier  . Glibenklamid  solid self emulsifying  ( SSE ) using a variation phase lipid of oleic acid and oleum  cocos , surfactant (  Tween 80) , and a variation of solid carrier (Avicel pH 101 , Lactose and Aerosil). Characterization results of glibenclamide  solid self-emulsifying  in-  vitro dissolution test using the medium of pH 7.4 phosphate buffer containing 8.5  % alcohol 96 % and 0.24 % tween 80 , sampling was conducted at 20, 40 , 60 , 80 , 100 and 120 minutes, were measured using a UV spectrophotometer at a wavelength 224 nm . The results showed that the formula 4 ( oleic acid  -  lactose ) release rate  62,628  %  at minute 120 , formula 5 ( oleic acid  -aerosil ) release rate  37,938 %,  formula 2 ( oleum cocos  -  lactose ) release rate 24,093 % , formula 3 (oleum cocos-avicel pH 101) release rate  23,689% , and the formula 1 (oleic acid - lactose ) release rate 21,977% . Key Words : Glibenclamide, SEDDS, Solid Carier, Dissolution. ABSTRAK   Penelitian formulasi glibenklamid dengan metode Self Emulsifying Drug Delivery Systems (SEDDS) dan  studi  in-vitro Disolusi bertujuan  untuk meningkatkan  laju disolusi glibenklamid dengan menggunakan sistem solid self emulsifying (SSE). Proses solid self-emulsifying dilakukan dengan metode adsorpsi ke dalam pembawa padatan (solid carrier). Formulasi Glibenklamid solid self emulsifying (SSE) menggunakan variasi minyak asam oleat dan oleum cocos, surfaktan (Tween 80), serta variasi solid carrier (Avicel pH 101, Laktosa dan Aerosil). Karakterisasi hasil glibenklamid solid self-emulsifying meliputi uji in-vitro disolusi menggunakan medium dapar posfat pH 7,4 mengandung 8,5 % alkohol 96% dan 0,24% tween 80, pengambilan sampel dilakukan pada menit ke- 20, 40, 60, 80, 100 dan 120 , kadarnya diukur menggunakan spektrofotometer UV pada panjang gelombang 224 nm. Dari hasil penelitian diketahui bahwa formula 4 (asam oleat-laktosa) terdisolusi hingga  62,628%  pada  menit  ke  120,  formula  5  (asam  oleat-aerosil)  terdisolusi 37,938%, formula 2 (oleum cocos-laktosa) terdisolusi 24,093%, formula 3 (asam oleat-avicel pH 101) terdisolusi 23,689%, dan formula 1 (oleum cocos-avicel pH 101) terdisolusi 21,977%.   Kata kunci : Glibenklamid, Sistem Solid Self Emulsifying (SSE), Solid carrier, Disolusi  
Co-Authors Aisyah F, Aisyah Anugrawan, Muh Anugrawan, Muh Doa, Febi Rofina Doa, Febi Rofina Fahimah, Nurul Fahimah, Nurul Fajriansyah, Fajriansyah Fajriansyah, Fajriansyah Fatima Fatima K, Nurul Alifah Laksono Trisnantoro Mangampa, Yunita Mangampa, Yunita Nuraisyah, Andi Nursamsiar Nursamsiar Radhia R, Radhia Rannu, Sriwanti Lisu Rannu, Sriwanti Lisu Risnayanti, Risnayanti Sahibuddin A Gani, Sahibuddin A Saputri, Nawalu Yusuf, Nurul Arfiyanti