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All Journal Jaringan Laboratorium Medis Tropical Health and Medical Research Journal
Aima Insana
Medical Laboratory Technology Poltekkes Kemenkes Banjarmasin, Indonesia
Religion Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Anti-Fungal Activity Test of Sengkuang (Dracontomelon dao) Leaf Ethanol Extract on The Growth of Candida albicans Aima Insana
Tropical Health and Medical Research Vol. 4 No. 1 (2022): Tropical Health and Medical Research
Publisher : Baiman Bauntung Batuah Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35916/thmr.v4i1.63

Abstract

Candida albicans is an important opportunistic fungal pathogen that is responsible for the majority of fungal infections in humans. In healthy individuals, Candida colonizes mainly on the mucosal surfaces of the oral cavity, digestive tract, skin and genitals. Dracontomelon dao or known as Sengkuang has been used as a traditional medicine for various diseases. Based on various studies, Dracontomelon dao extract is reported to exhibit antimicrobial properties. This study aimed to analyze the antifungal activity of the ethanol extract of sengkuang (Dracontomelon dao) leaves on the growth of Candida albicans. The study used 96% ethanol extract by macerating the simplicia leaves of Dracontomelon dao originating from South Kalimantan, Indonesia. The antifungal activity was tested by well diffusion method at various concentrations of the test extract (10%, 20%, 30%, 40% and 50%). The results showed that the average diameter of the inhibition zones at concentrations of 10%, 20%, 30%, 40% 50% were 19.2 mm, 21.8 mm, 23.2 mm, 24.8 mm, 27 mm, respectively. Based on the results of the study, it was found that the ethanolic extract of sengkuang (Dracontomelon dao) leaves had antifungal properties against the growth of Candida albicans with the most effective concentration at a concentration of 50% with an average zone diameter of 27 mm. The content of phytochemical compounds from sengkuang leaf extract (Dracontomelon dao) are flavonoids, alkaloids, saponins, tannins, and triterpenoids. This secondary metabolite is thought to be able to inhibit the growth of the fungus Candida albicans. The ethanol extract of sengkuang leaves (Dracontomelon dao) has been shown to have antifungal activity in vitro so that it has the potential to be developed as an antifungal agent and can be a new solution in handling cases of Candida albicans infection.
Pengaruh Lama Penyimpanan Jamu Beras Kencur terhadap Pertumbuhan Kapang Fransiskus Xaverius Agung Pinto Laksono; Ratih Dewi Dwiyanti; Rifqoh Rifqoh; Aima Insana
Jaringan Laboratorium Medis Vol 4, No 2 (2022): November 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i2.8571

Abstract

During the Covid-19 pandemic, people began to maintain their health, by using herbal medicine as an alternative treatment. One type of herbal medicine used is jamu beras kencur because it has properties to increase stamina, increase appetite, and relieve aches and cough disorders. In the Regulation of the Minister of Health of the Republic of Indonesia No. 007 of 2012 carrying herbs such as jamu beras kencur does not require marketing authorization. The quality of the herbal medicine produced has not been confirmed as feasible from microbial contamination, especially in molds, the number of yeast molds in the jamu beras kencur must comply with BPOM standards Number 32 of 2019 namely AKK 103 colonies/mL. This study aimed to determine the effect of the storage time of jamu beras kencur on mold growth with storage treatments of 0 hours, 4 hours, 8 hours, 12 hours, and 24 hours at room temperature. This type of research is a Quasi Experiment with a research design of One Group Pretest-Postest Design. The results of this study showed that the average AKK value was 0 hours 0.2x100 colonies/mL, 4 hours 0.4x100 colonies/mL, 8 hours 0.4x100 colonies/mL. 12 hours 0.8x100 colonies/mL and 24 hours 2.2x100 colonies/mL. These results stated that the jamu beras kencur met the BPOM standard requirements Number 32 of 2019 which was AKK 103 Colonies/mL. The results of the Kruskal Wallis test obtained a sig value of 0.286, it was concluded that there was no effect of storage time for the jamu beras kencur on the growth of molds. The identification results on the jamu beras kencur obtained fungal species, namely Aspergillus flavus, Aspergillus niger, and Penicillium sp. Suggestions for further researchers can examine the effect of storage time on mold growth in other types of herbal medicine.
Co-Authors Fransiskus Xaverius Agung Pinto Laksono Ratih Dewi Dwiyanti Rifqoh Rifqoh