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All Journal Jurnal Ilmiah Pertanian Acta Biochimica Indonesiana
Kholis Abdurachim Audah
Department of Biomedical Engineering, Swiss German University, Tangerang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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Antioxidant and antibacterial activity of mangrove Brugueira gymnorrhiza stem extracts against pathogenic bacteria Vibrio cholerae Angga Crystal Loasana Yami; Irmanida Batubara; Kholis Abdurachim Audah
Acta Biochimica Indonesiana Vol. 3 No. 2 (2020): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v3i2.51

Abstract

Background : The treatment of some diseases caused by free radicals and pathogenic bacteria usually by using antioxidants and antibiotics. Due to excessive use of antibiotics and other environmental cues, some bacteria are now resistant to certain antibiotics or even to multiple antibiotics. Some Vibrio cholerae bacterial strains are multiresistant to many antibiotics. Objective : The antioxidant and antibacterial activities of Brugueira gymnorrhiza stem extracts against pathogenic bacteria V. cholerae. Method : The B. gymnorrhiza stem was extracted by gradient maceration method. The DPPH method was used to determine the antioxidant activity and the disc diffusion method was used to determine the antibacterial activities. The column chromatography method was used to fractionate the selective extract with the best activity. The LC-MS/MS method was used to identify the compound obtained from the fraction with the best antioxidant and antibacterial activity. Result : Ethyl acetate extract of B. gymnorrhiza stem had the best antibacterial activity with MIC and MBC values of 62.50 mg/L. Ethyl acetate extract also showed the best value of antioxidant activity as indicated by an IC50 value of 255.03 mg/L. The results of fractions test showed that fraction 3 had the best antibacterial and the best antioxidant activities with both the MIC and MBC values of 7.90 mg/L and IC50 value of 348.91 mg/L, respectively. Conclusion : Ethyl acetate extract of B. gymnorrhiza stem has good potential as antioxidant and antibacterial. The compound which is thought as antioxidant and antibacterial from Ethyl acetate extract is 2-Ethyl-4-methyl-1H-imidazole.
Heavy metal contamination status in the soil-water-rice system near coal-fired power plants in Cilacap, Indonesia Febbyandi Isnanda Pandiangan; Kholis Abdurachim Audah
Jurnal Ilmiah Pertanian Vol. 19 No. 3 (2022): Jurnal Ilmiah Pertanian
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/jip.v19i3.10568

Abstract

Indonesia is intensively developing plenty of coal-fired power plants to support electricity demand growth. Some research showed the utilization of coal as an electrical energy source may produce anthropogenic contaminants (ACs) that can bioaccumulate in plants. This research was carried out to investigate the severity of the heavy metals contamination problem, for instance, arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) in soil, water, rice, and rice bran using ICP-MS and ICP-OES. This research demonstrated the metal contamination levels of arsenic, cadmium, mercury, and lead in the soil, water, rice, and rice bran were below the maximum limit, according to SNI, Codex, and FAO/WHO. However, only a rice sample showed the lead (Pb) level above the safe limit. Coal-fired power plant activities in Cilacap did not indicate clear evidence of soil, water, rice, and bran heavy metal contamination. Therefore, transformation to green energy (e.g., solar and geothermal) is highly recommended to minimize the potential health risks of environmental pollution due to the coal-fired power plant's by-product activities.
Co-Authors Angga Crystal Loasana Yami Febbyandi Isnanda Pandiangan Irmanida Batubara