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All Journal Jurnal Kimia Terapan Indonesia Jurnal Farmasi Higea SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Sylvia Rizky Prima
Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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STUDI PERSEPSI DOKTER TENTANG PERAN APOTEKER DALAM PELAYANAN KEFARMASIAN DI RUMAH SAKIT UMUM PUSAT (RSUP) DR. M. DJAMIL PADANG Sylvia Rizky Prima
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 1, No 2 (2016)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v1i2.617

Abstract

ABSTRACT The main of this study was to investigate physicians’expectations and experiences regarding pharrmaceutical care in hospital of  DR. M. Djamil Padang. A four-part quetionnaire was hand delivered to a sample of 380 physicians practicing in hospital of  DR. M. Djamil Padang. The questionnaire collected physicians’ characteristic, current expectations, actual experiences and future expectations regarding pharmaceutical care. Two hundred and two (53,16%) questionnaires were returned. In general, the mean values of physician agreement in our study showed that there is neither strong agreement nor strong disagreement with any statement regarding physicians’current expectations and future expectations of pharmacists. It is concluded that physicians as whole do not know what to expect of pharmacist. But, our study showed that with the actual experiences of Physicians with Pharmacists are still very low. Keywords: physician’s perceptions, expectations dan experience of physicians, pharmaceutical care ABSTRAK Tujuan utama penelitian ini adalah untuk menginvestigasi harapan dan pengalaman dokter terhadap peran apoteker dalam pharmaceutical care di Rumah Sakit DR. M. Djamil Padang. 4 bagian kuesioner telah berhasil diserahkan kepada 380 sampel dokter praktek di Rumah Sakit DR. M. Djmail Padang. Kuesioner berisi data karakteristik dokter, harapan dokter saat ini, pengalaman aktual dokter, dan harapan dokter terhadap peran apoteker terkait pharmaceutical care. 202 kuesioner berhasil diperoleh kembali (53,16%). Secara umum, rata-rata respon dokter untuk harapan dokter saat ini dan harapan dokter dimasa depan terhadap peran apoteker dalam pharmaceutical care tidak terlalu tinggi dan tidak terlalu rendah.  Tetapi, dari hasil penelitian ini menunjukkan bahwa pengalaman aktual dokter dengan apoteker dalam hal pharmaceutical care masih sangat rendah. Kata kunci: Persepsi dokter, harapan dan pengalaman dokter, pharmaceutical care
PERBANDINGAN JENIS, KOMPOSISI DAN JUMLAH PELARUT TERHADAP UJI TOTAL FLAVONOID DARI DAUN JAWER KOTOK (Plectranthus scutellarioides(L.) R.Br.) Sylvia Rizky Prima; Fetri cary munarsih; Ulia Nailis Saadah
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (633.036 KB) | DOI: 10.52689/higea.v10i2.192

Abstract

Tanaman Jawer Kotok (Plectranthus scutellarioides (L.) R.Br.) adalah tanaman obat tradisional yang digunakan oleh masyarakat untuk mengobati berbagai penyakit. Salah satu senyawa yang berperan penting dalam mengobati berbagai penyakit tersebut adalah senyawa flavonoid. Tujuan dari Penelitian ini adalah untuk memperoleh jenis pelarut, komposisi dan jumlah pelarut yang optimal mengahsilkan total flavonoid dari daun jawer (Plectranthus scutellarioides) (L.) R.Br. Pada penelitian ini digunakan jenis pelarut etanol dan aseton dengan komposisi perbandingan pelarut : air mulai dari 96: 4, 80:20, 70:30, 60:40 dan 50:50. Jumlah pelarut yang digunakan yaitu dengan perbandingan pelarut 5x berat sampel, 10x berat sampel dan 15x berat sampel. Metode ekstraksi yang digunakan adalah metode maserasi. Metode pengujian total flavonoid yang digunakan adalah metode kolorimertri dengan pembanding Quersetin. Dari hasil penelitian diperoleh bahwa pelarut terbaik untuk mengekstraksi total flavonoid adalah pelarut Aseton : Air (70 : 30). Berdasrakan analisa data dengan menggunakan SPPS v24, perbandingan jumlah pelarut 5x, 10 dan 15x berat sampel tidak memiliki perbedaan yang signifikan.
The Synthesis of Cinchonine Tiglat Ester Compound and Cytotoxic Test Against MCF-7 Breast Cancer Cell Ahmad Khanifudin; Gian Primahana; Sylvia Rizky Prima; Puspa Dewi Lotulung; Muhammad Hanafi
Jurnal Kimia Terapan Indonesia Vol 19, No 2 (2017)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (527.773 KB) | DOI: 10.14203/jkti.v19i2.354

Abstract

Cinchonine is a type of cinchona alkaloid compound commonly found and/or isolated from Cinchona sp. plant. It is commonly used to treat malaria, and can potentially be used against cancer cells. In this particular study, cinchonine ester derivatives were extracted through esterification processs. Synthesized esther is aimed to gain higher lipophilicity of cinchonine so that makes it easier to pass through cell membrane. Esterification was done using DCC activator as well as DMAP catalyst with tiglic acid used to create cinchonine tiglat. Subsequent cinchonine tiglat was obtained in the form of oil with 25,28% yield. The compound obtained from the synthesis was the analyzed using LC-ESI-MS and 1H-NMR spectroscopy instrumentation. Results show that the target compound has been successfully synthesized. Its cytotoxic ability against MCF-7 breast cancer cells was tested using the Alamar Blue method. Results concluded that cinchonine tiglat ester compound has a viable cytotoxic activity with IC50 value of 1.22 ppm. 
Synthesis and cytotoxicity assay using Brine Shrimp Lethality Test of Cinchonidine Isobutyrate Ester Mario Mario; Puspa Dewi Lotulung; Gian Primahana; Sylvia Rizky Prima; Muhammad Hanafi
Jurnal Kimia Terapan Indonesia Vol 19, No 1 (2017)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.382 KB) | DOI: 10.14203/jkti.v19i1.328

Abstract

This research was aimed to synthesize cinchonidine isobutyrate ester and conduct a preliminary assay for anticancer agent using cytotoxicity assay to Artemia salina Leach larva, or also known as brine shrimp lethality test (BSLT). Cinchonidine, a compound that has quinoline rings and quiniclidine ring, is a quinine analogue and stereoisomer of cinchonine. Cinchonidine is predicted to have anticancer activity. Synthesized ester was aimed to gain higher lipophilicity. Higher lipophilicity makes it easier for the compund to pass through cell membrane. The esterification process used DMAP as a catalyst, DCC as an activator, and isobutyric acid as a carboxilyc acid. Isobutyric acid is a type of short chained fatty acid that usually acts as an anticancer prodrugs. The product is identified by ESI-MS, FT-IR, 1H-NMR, dan 13C-NMR. Ester cinchonidine isobutyrate is gelatinous and colourless with yield of 21,77%. BSLT result showed that cinchonidine isobutyrate ester had LC50 value of 75.16 ppm which was more toxic than cinchonidine that had LC50 value of 99.2 ppm. It was proved that higher lipophilicity could increase pharmacology activity
Co-Authors Ahmad Khanifudin Fetri cary munarsih Gian Primahana Gian Primahana Mario Mario Muhammad Hanafi Muhammad Hanafi Puspa Dewi Lotulung Puspa Dewi Lotulung Ulia Nailis Saadah