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All Journal Indonesian Journal of Cardiology Heart Science Journal
Djanggan Sargowo
Brawijaya University
Health Professions Immunology & microbiology Medicine & Pharmacology

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Korelasi Antara Kadar Lp-PLA2, MDA, F2-Isp di Serum dan Jaringan Aorta dengan Jumlah Sel Busa dalam Proses Aterogenesis pada Tikus Wistar Retno Susilowati; Djanggan Sargowo; Rasjad Indra; Askandar Tjokroprawiro; Sri Widyarti
Jurnal Kardiologi Indonesia Vol. 33, No. 4 Oktober - Desember 2012
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v33i4.288

Abstract

Background. Atherogenesiswas initiated by cholesterol deposits on foam cell in sub intimae of blood vessel stress oxidation. Atherogenesis in non- hypercolesterolemiausually undergoes an increased level of Lp-PLA2. It, therefore, needs to evaluate the role of Lp-PLA2in the foam cell formation. Aims. To explain the role of Lp-PLA2 in the foam cell forming, to correlate the level of Lp-PLA2 ,MDA, F2-Isp in aorta with foam cell number (FCs) as well as to correlate the level of Lp-PLA2 , MDA, F2-Isp contents in serumwith their contents in aorta and the correlation with FCs.Methods. 30 rats aged 2 months, with their weight averaging from 150-200g,were divided into the control group and the treatment one where the latterwas fed hyperlidemia for 2,8 and 12 weeks. The measurement level of LDL-C,MDA, F2-isp and Lp-PLA2in serum was performedas well as aorta and FCs. Data was analysed using anova, t-Test, path analysis and correlation. Results. Research result indicated that: (1) The level of MDA(a), F2-Isp(s) and Lp-PLA2(s) positively correlated with FCs, Lp-PLA(s)having the highestcorrelation value. (2) Lp-PLA2(a),MDA(s) and F2-Isp(s,a)did not correlate withFCs. (3) There was a positive correlation between Lp-PLA2 with MDA andF2-Isp in both serum and aorta.Conclusion. The enzyme of Lp-PLA2 acts as an activator in forming thefoam cell with stimulated stress oxidation.
Cardiomyopathy and Frequent Monomorphic PVC : Which One Comes First? Anita Surya Santoso; Djanggan Sargowo; Ardian Rizal
Heart Science Journal Vol 3, No 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.03.8

Abstract

A 28-year-old male wasaadmittedto hospitalwwith chief complaint chestadiscomfort. There were symptoms of dyspnea on effort and palpitation before. He had a history of alcoholics for more than five years. The ECG showed frequent Premature Ventricular Complex (PVC) and recommended to have ambulatory Holter monitoring with conclusion frequent monomorphic right ventricle outflow tract (RVOT) origin PVC. Echocardiography indicated a decrease in left ventricular (LV) function, LV dilatation, and global hypokinetic. Cardiac Magnetic Resonance Imaging (CMR) was performed, and there was no “edema”and myocardium fibrosis. It is essential to analyze which comes first, arrhythmia induced cardiomyopathy (AIC), or cardiomyopathy induced arrhythmia to have direct treatment. From the collected data, we conclude that the frequent RVOT origin PVC induced cardiomyopathy and catheter ablation is the definitive therapy.
Co-Authors Anita Surya Santoso Ardian Rizal Askandar Tjokroprawiro Rasjad Indra Retno Susilowati Sri Widyarti