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DESCRIPTION OF UREA AND CREATININE LEVELS IN CHRONIC RENAL FAILURE PATIENTS AT WIRADADI HUSADA HOSPlTAL Fitri Nuroini; Wahyu Wijayanto
Jambura Journal of Health Sciences and Research Vol 4, No 2 (2022): Jambura Journal of Health Sciences and Research
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i2.13199

Abstract

Abstrak Penyakit gagal ginjal kronis merupakan suatu proses patofisiologis dengan berbagai macam penyebab dan bersifat ireversibel. Gambaran klinis akan terlihat nyata apabila kadar ureum darah lebih dari 200 mg/dL. Konsentrasi ureum darah merupakan indikator adanya retensi sisa-sisa metabolisme protein di dalam tubuh. Tujuan penelitian adalah untuk mengetahui gambaran kadar ureum dan kreatinin pada pasien gagal ginjal kronis di RSU Wiradadi Husada. Jenis penelitian deskriptif observasional, dengan sampel penelitian semua pasien dengan diganosis gagal ginjal kronis di RSU Wiradadi Husada pada bulan Desember 2020 – Januari 2021 sesuai dengan kriteria inklusi dan eksklusi, sebanyak 80 sampel. Pemeriksaan kadar ureum dan kreatinin menggunakan sampel serum dengan automatic chemistry analyzer (TECOM TC 220). Hasil penelitian menunjukan bahwa mayoritas pasien penyakit gagal ginjal kronis dialami oleh lansia yaitu usia 46-65 tahun sebanyak 51,25% (41 pasien) dan sebagian besar diderita oleh pria 53,75% (43 pasien). Gambaran kadar ureum dan kreatinin pada semua sampel menunjukan hasil yang melebihi nilai normal. Rerata kadar ureum pada pria 169 mg/dL dan pada wanita 158 mg/dL, sedangkan rerata kadar kreatinin pada pria 4,58 mg/dL dan pada wanita 3,35 mg/dL. Simpulan penelitian  adalah kadar ureum dan kreatinin serum semua pasien penyakit gagal ginjal di RSU Wiradadi Husada melebihi nilai normal (nilai normal ureum 20 – 40 mg/dL, untuk kreatinin pria 0,6-1,1 mg/dL dan wanita 0,5-0,8 mg/dL). Kata Kunci: Gagal Ginjal Kronik; Kadar Kreatinin; Kadar Ureum Abstract Chronic kidney failure is a pathophysiological process with various causes and is irreversible. The clinical symptom is a blood urea level of more than 200 mg/dL. Blood urea concentration is an indicator of the retention of protein metabolism residues in the body. The aim of this study was to describe the levels of urea and creatinine in patients with chronic kidney failure at RSU Wiradadi Husada. This type of research is descriptive, all patients with kidney failure at RSU Wiradadi Husada from December 2020 to January 2021 (80 patients), as samples. The results showed that the majority of patients with chronic kidney disease were aged 46–65 years, as many as 51.25% (41 patients), and most of them were suffered by men, 53.75% (43). The determination of urea and creatinine levels in all samples showed results that exceeded normal values. The average level of urea in men is 169 mg/dL and in women, it is 158 mg/dL, while the mean creatinine level in men is 4.58 mg/dL and in women, it is 3.35 mg/dL. The serum urea and creatinine levels of all patients with kidney failure at RSU Wiradadi Husada exceeded normal values (urea range reference 20-40 mg/dL, creatinine 0,6-1,1 mg/dL for men and 0,5-0,8 mg/dL for women).
Maternal interleukin-6 and prostaglandin levels post-regiosacral counter-pressure as pain therapy due to uterine contractions Sri Rejeki; Achmad Solichan; Fitri Nuroini
Media Keperawatan Indonesia Vol 4, No 4 (2021)
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1897.616 KB) | DOI: 10.26714/mki.4.4.2021.291-297

Abstract

Pain is a physiological condition that is generally experienced by almost all mothers in labor or pain during menstruation (dysmenorrhea). Pain causes tachycardia in the mother, increased oxygen consumption, lactic (lactic) acid production, hyperventilation with a risk of respiratory alkalosis, and increased skeletal muscle tension. Regiosarcal Counter Pressure is an effective therapy to reduce pain due to uterine contractions. Based on research that has been done, Regiosarcal counter-pressure therapy can reduce pain levels and has also been shown to slightly reduce prostaglandin (PGE-2) levels in an insignificant amount. Changes in PGE-2 are suspected to have an impact on the stimulant hormone Interleukin-6 (IL-6). This study aims to determine the levels of IL-6 and prostaglandins in the first stage of labor. The research method used quasi-experimental, with inclusion criteria of first-stage labor, no pelvic abnormalities and other abnormalities that hindered the process of vaginal delivery, primiparas, singleton pregnancies, the location of the head did not receive painkillers. The results obtained 25 respondents with an average age of 23.72 (± 2.89) years, the average concentration of IL-6 before therapy was 185.159 (± 3.76) pg/ml and the mean after therapy was 180.782 (± 22.05) pg. /ml, the mean concentration of PGE2 before treatment was 223.521 (± 72.73) pg/ml and the mean after treatment was 179.873 (± 110.61) pg/ml. Administration of regiosacral counter-pressure therapy did not significantly reduce the levels of the hormone IL-6 and prostaglandins in women who experienced uterine contractions.
GAMBARAN JARINGAN HATI PADA PROSES CLEARING MENGGUNAKAN EKSTRAK JERUK NIPIS PADA PEWARNAAN HEMATOKSILIN EOSIN Yulya Putri Wulandari; Fitri Nuroini; Tuus Ariyadi
Binar – Biology Natural Resources Journal Vol 1 No 1 (2022)
Publisher : Prodi Biologi Universitas PGRI Ronggolawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.388 KB) | DOI: 10.55719/Binar.2022.1.1.46-50

Abstract

Histoteknik adalah metode untuk membuat preparat histologi, dalam proses histoteknik terdapat clearing prosesing jaringan dan clearing pewarnaan HE. Jeruk nipis mengandung asam sitrat 7-7,6% kandungan tersebut dapat menggantikan xylol dalam agent clearing. Tujuan penelitian ini untuk mengetahui gambaran jaringan hati pada pross clearing menggunakan ekstrak jeruk nipis pada prosesing jaringan dan pewarnaan HE. Jenis penelitian deskriptif, obyek penelitian adalah organ dan preparat hati marmut, tahap clearing prosesing jaringan dan pewarnaan HE menggunakan ekstrak jeruk nipis. Penilaian kualitas jaringan dan preparat mengunakan skoring 1-3 dengan penilaian tidak baik, kurang baik dan baik. Hasil clearing prosesing jaringan diperoleh skor 1 dengan nilai tidak baik yaitu jaringan terlihat tidak jernih dan transparan. Pengamatan kualitas preparat hati dengan pewarnaan HE diperoleh skor 2 dengan nilai kurang baik dengan warna ungu pada inti sel dan warna merah muda pada sitoplasma terlihat kurang jelas serta warna preparat sama. Ekstrak jeruk nipis menunjukkan hasil yang tidak baik apabila digunakan pada tahap clearing prosesing jaringan maupun tahap pewarnaan HE pada jarigan hati.