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All Journal MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Herb-Medicine Journal ARTERI : Jurnal Ilmu Kesehatan
Risma Karlina Prabawati
Universitas Muhammadiyah Malang
Biochemistry, Genetics & Molecular Biology Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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PENGARUH ANTOSIANIN UBI UNGU (Ipomoea batatas L.) KULTIVAR GUNUNG KAWI TERHADAP EKSPRESI CASPASE-3 PADA JARINGAN OTAK TIKUS MODEL DM TIPE 2 Prakosa, Ardani Galih; Ratnawati, Retty; Prabawati, Risma Karlina
Majalah Kesehatan FKUB Vol 4, No 2 (2017): MAJALAH KESEHATAN FAKULTAS KEDOKTERAN
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.081 KB) | DOI: 10.21776/ub.majalahkesehatan.2017.004.02.1

Abstract

Diabetes melitus (DM) merupakangangguan metabolism yang menyebabkan kondisi hiperglikemia. Hiperglikemia akan memicu pembentukan radikal bebas. Radikal bebas yang berlebihan dapat merusak sistem membran sel dan kematian sel di berbagai jaringan tubuh. Salah satu penanda terjadinya kematian sel pada suatu jaringan adalah caspase-3. Ubi ungu merupakan tanaman tradisional yang mengandung antosianin yang bermanfaat sebagai antiinflamasi, antioksidan, neuroprotektan, dan antidiabetik. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian antosianin ubi ungu terhadap ekspresi caspase-3  pada jaringan otak tikus Wistar yang diinduksi DM tipe 2. Penelitian ini menggunakan desain eksperimental post-test only control group. Sampel penelitian terbagi menjadi 5 kelompok  yaitu kontrol negatif, kontrol positif, antosianin dosis 10 mg/kgBB, dosis 20 mg/kgBB, dan dosis 80 mg/kgBB selama 5 minggu. Kontrol positif adalah tikus yang dibuat DM tipe 2, sedangkan kontrol negatif adalah tikus sehat. Ekspresi caspase-3 diukur dengan metode imunohistokimia. Analisis statistik menunjukkan bahwa ekspresi caspase-3 berbeda secara bermakna pada semua kelompok perlakuan (ANOVA, p<0,05). Pemberian antosianin dosis 10 dan 20 mg/kgBB menurunkan ekspresi caspase-3 secara bermakna dibandingkan kontrol positif, sedangkan pemberian antosianindosis 80 mg/kgBB justru meningkatkan ekspresi caspase-3. Dapat disimpulkan bahwa pemberian antosianin dosis 10 dan 20 mg/kgBB menurunkan ekspresi caspase-3 pada jaringan otak tikus wistar model DM tipe 2. Kata kunci: antosianin, ekspresi caspase-3, hiperglikemia, jaringan otak
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS Prabawati, Risma Karlina; Ratnawati, Retty; Rahayu, Masruroh; Prakosa, Ardani Galih
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.6

Abstract

Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been 2 found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic.Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats.Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10 mg/kg, 20 mg/kg, and 80 mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test.Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test.Conclusion: Anthocyanin doses 10 and 20 mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats.
Profil Pekerja Pemanen Kelapa Sawit Bagian Cutting Egrek Risma Karlina Prabawati; Erna Lidiana
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 2 (2021): Herb-Medicine Journal April 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i2.9931

Abstract

Musculoskeletal Disorders (MSDs) is a label for the perception of pain or pain in the musculoskeletal system. MSDs can be caused by the equipment, techniques, and activities performed during work. Harvesters who use manual techniques or cutting egrek have the potential risk for MSDs as a result of an ergonomic work attitude and posture. This study aims to determine the profile of oil palm harvesters using cutting egrek techniques. This research is a descriptive research with the survey method. Samples were obtained by systematic random sampling method, amounting to 82 people. The data used in this study are primary data and secondary data. Most CuE technique oil palm harvesters were at the age of 41-50 years, working period of 6-10 years, and with a work posture that needed immediate improvement, and 76.8% suffered from MSDs complaints. So that it is necessary to have immediate intervention from companies and workers to reduce the risk of MSDs complaints in the future, especially in posture and work techniques.
Profil Penderita Stroke Berulang Rumah Sakit Muhammadiyah Malang Periode Juli-Agustus 2019 Risma Karlina Prabawati; Azizah Siena Pitaloka
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 3 (2021): Herb-Medicine Journal Juli 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i3.8147

Abstract

Stroke dapat mempengaruhi kehidupan penderita, baik berupa kecacatan maupun kematian. Stroke dibagi menjadi stroke iskemik dan perdarahan. Terjadinya stroke berulang dapat mempengaruhi status kognitif dan angka harapan hidup penderita. Penelitian ini bertujuan untuk mengetahui profil penderita stroke berulang di Poliklinik Saraf Rumah Sakit Muhammadiyah Malang pada bulan Juli-Agustus 2019. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional. Stroke berulang terjadi terbanyak pada laki-laki (54.26%), usia 56-65 tahun (41.5%), dan tingkat pendidikan perguruan tinggi (30%). Stroke berulang sering terjadi pada pasien dengan usia yang lebih tinggi, pendidikan tinggi, dan adanya riwayat hipertensi. Upaya promotif dan preventif berupa edukasi dan promosi kesehatan sebaiknya selalu dilakukan agar tidak terjadi stroke berulang yang beresiko memperburuk fungsi kognitif.
Potensi Ekstrak Jagung Sebagai Pencegahan Katarak Sri Mariati; Danang Diasrullah Bhekti; Alfa Sylvestris; Risma Karlina Prabawati
ARTERI : Jurnal Ilmu Kesehatan Vol 4 No 1 (2022): November
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v4i1.246

Abstract

Senile cataract is a cataract caused by the aging process that begins at the age of more than 50 years caused by free radicals, such as reactive oxygen species (ROS), formed as a result of external and internal exposure. Utilization of the potential of this corn extract has advantages with minimal side effects by utilizing corn extract, namely lutein zeaxanthin as a prevention of senile cataract. The main purpose of this literature review is to determine the potential of corn extract (Zea mays sp.) on the prevention of senile cataract. This research is literature study using national and international journals with the Scopus index published in 2016-2021 as well as literature books. Journals were obtained from search engines Google Scholar and Pubmed NCBI. Data and information obtained to support the research objectives. Cataracts are caused by Reactive Oxidative Stress (ROS). Zeaxanthin compounds work with their antioxidant properties by activating the synthesis of glutathione (GSH) in human RPE cells. Zeaxanthin increases the translocation of Nuclear receptor factor 2(Nrf2) by reducing the binding activity of Nrf2 to Kelch like ECH-Aasosiated protein 1 (Keapl1) in ARPE-19 cells. Furthermore, inhibition of GSH synthesis by buthionine suphoximine abolished the protective effect of zeaxanthin against oxidative stress-induced reduction of mitochondrial membrane potential and cell apoptosis in ARPE-19 cells thereby helping to prevent the formation of oxidative stress causing senile cataract. Corn extract (Zea mays sp.) has potential in the prevention of senile cataract because it has good antioxidant activity
Co-Authors Alfa Sylvestris Ardani Galih Prakosa, Ardani Galih Azizah Siena Pitaloka Danang Diasrullah Bhekti Erna Lidiana Masruroh Rahayu, Masruroh Retty Ratnawati Sri Mariati