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AKTIVITAS IMUNOMODULATOR EKSTRAK ETANOL SPONS Callyspongia sp. TERHADAP FAGOSITOSIS MAKROFAG PADA MENCIT JANTAN BALB/C. Muhammad Ilyas Y.; Asriullah Jabbar; Mentarri Bafadal; Muhammad Hajrul Malaka; Firdayanti Firdayanti; I. Sahidin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 1 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.441 KB) | DOI: 10.36387/jiis.v5i1.377

Abstract

Sponge Callyspongia sp. has compounds that act as immunomodulatory agents, one of which is flavonoids.Flavonoids have the potential to be immunostimulants by increasing the phagocytic activity of macrophages. This study was experimental with a post test only control group design method. This study used 24 micemalestrain Balb /c with a body weight of 20-30 grams divided into 6 groups. The first group get extracts of sponge Callyspongia sp. 100 mg/kgBW, second group get the extract of sponge Callyspongia sp. 200 mg/kgBW, third group get extracts of sponge Callyspongia sp. 300 mg/kgBW, fourth group get the extract of sponge Callyspongia sp. 400 mg/kgBW, positive control group was given Stimuno® 0,13 mg/kgBW and the negative control group get Na-CMC 0.5%. A test given in orally preparations on the first day until the seven day. On the eighth day of each of the mice are injected bacteria Staphylococcus aureus (SA) by intraperitoneal. The activity of macrophage cells from murine peritoneal fluids sweep by calculating the percentage of macrophages that does phagocytosis of 100 cells are observed. The data obtained were then analyzed by one way Anova statistics and test post hoc Tukey's. As result, the are that ethanol extracts of sponge Callyspongia sp. at doses of 300 mg/kgBW and 400 mg/kgBW have potential as immunomodulator with based on results of statistical tests post hoc Tukey (P > 0.05) showed no meaningful difference against the positive control (Stimuno ®) wich improving the activity of the cells of the macrophage phagocytosis.
Gambaran Kadar Bilirubin Total pada Penderita Tuberkulosis Paru dengan Terapi Obat Anti Tuberkulosis (Oat) di Puskesmas Poasia Kota Kendari Firdayanti Firdayanti
Jurnal Kesehatan Vokasional Vol 4, No 3 (2019): Agustus
Publisher : Sekolah Vokasi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.753 KB) | DOI: 10.22146/jkesvo.44487

Abstract

Background: Treatment of tuberculosis by using anti-tuberculosis drugs (OAT) can be accepted in therapy, but has potential effectiveness such as side effects of hematologic reactions, namely anemia, agranulocytosis, eosinophilia and thrombocytopenia, and liver function. Hyperbilirubinemia is one of the side effects of using OAT which is often complained by patients.Objective: to determine the description of total bilirubin levels in tuberculosis patients with OAT therapy at the Poasia Health Center in Kendari CityMethod: This study was descriptive with bilirubin examination using the Jendrassik-Grof method by spectrophotometer. Total bilirubin examination was performed on 18 pulmonary tuberculosis patients who received OAT therapy at the Poasia Health Center in Kendari City.Results: The results of the study showed that from 18 samples examined, there were 10 samples with high bilirubin levels (hyperbilirubinemia) and 8 samples had normal bilirubin levels.Conclusion: Total bilirubin levels in patients with pulmonary tuberculosis with OAT therapy were found as many as 10 patients had high bilirubin levels (hyperbilirubinemia) and 8 patients had normal bilirubin levels. Keywords: Bilirubin, Hyperbilirubinemia, OAT, Therapy, Tuberculosis
GAMBARAN KADAR SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGOT) DAN SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGPT) PADA PASIEN JIWA DENGAN TERAPI ANTIPSIKOTIK Firdayanti Firdayanti; Sernita Sernita; Ani Umar
Jurnal Analis Kesehatan Kendari Vol 3 No 2 (2021): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 3 (2) Juni 2021)
Publisher : Program Studi Diploma III Analis Kesehatan Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.237 KB) | DOI: 10.46356/jakk.v3i2.111

Abstract

ABSTRACT Mental disorder is a physiological process or mentally said a person cannot function properly so that it interferes with daily activities. Handling mental patients with antipsychotic therapy is a pharmacological therapy. Therapy aims to restore the patient's normal function and prevent recurrence of the disease. Side effects were shown in hospitalized psychiatric patients given antipsychotic therapy, one of which was an increase in liver enzyme levels (SGOT and SGPT). The purpose of this study was to describe the levels of SGOT and SGPT in mental patients receiving antipsychotic therapy. This study was a descriptive study with a cross sectional study design. The levels of SGOT and SGPT enzymes were obtained by examining serum from mental patients with enzymatic methods using a spectrophotometer. The results showed that 15 (27%) mental patients with SGOT and SGPT levels were examined from 15 mental patients with SGPT and SGPT, 3 (20%) mental patients with high SGOT levels, and 8 (53%) mental patients with high levels of SGOT. SGOT and SGPT are normal. Keywords: Antipsychotics, Liver, Mental Patients, SGOT, SGPT ABSTRAK Gangguan jiwa merupakan proses fisiologis atau dikatakan mental seseorang tidak dapat berfungsi dengan baik sehingga mengganggu dalam aktivitas sehari-hari. Penanganan pasien gangguan jiwa dengan dilakukan pemberian terapi antipsikotik yang merupakan terapi farmakologi. Terapi bertujuan untuk mengembalikan fungsi normal pasien dan mencegah kekambuhan penyakitnya. Efek samping ditunjukkan pada pasien gangguan jiwa rawat inap yang diberikan terapi antipsikotik, salah satunya peningkatan kadar enzim hati (SGOT dan SGPT). Tujuan penelitian ini adalah untuk mengetahui gambaran kadar SGOT dan SGPT pada pasien jiwa yang mendapatkan terapi antipsikotik. Penelitian ini adalah penelitian deskriptif dengan rancangan cross sectional study. Kadar enzim SGOT dan SGPT diperoleh dengan dilakukan pemeriksaan serum dari pasien gangguan jiwa dengan metode enzimatik menggunakan spektrofotometer. Hasil penelitian menunjukkan dari 15 pasien jiwa yang dilakukan pemeriksaan SGOT dan SGPT dijumpai 4 (27%) pasien jiwa dengan kadar SGOT dan SGPT tinggi, 3 (20%) pasien jiwa dengan kadar SGOT tinggi, dan 8 (53%) pasien jiwa dengan kadar SGOT dan SGPT normal. Kata kunci : Antipsikotik, Hati, Pasien Jiwa, SGOT, SGPT
GAMBARAN NILAI TROMBOSIT PADA PASIEN TUBERCULOSIS PARU YANG MENDAPAT PAKET OBAT ANTI TUBERKULOSIS (OAT) DI RUMAH SAKIT UMUM DAERAH KOTA KENDARI Muhammad Ilyas Yusuf; Firdayanti Firdayanti; Salmawati Salmawati
Jurnal Analis Kesehatan Kendari Vol 3 No 2 (2021): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 3 (2) Juni 2021)
Publisher : Program Studi Diploma III Analis Kesehatan Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.669 KB) | DOI: 10.46356/jakk.v3i2.112

Abstract

ABSTRACT Tuberculosis (TB) is an infectious disease that attacks the lungs caused by the bacteria Mycobacterium tuberculosis is transmitted through the air. One of the drugs used for TB disease rifampisin known as a cause of thrombocytopenia. This study aims to describe the number of platelets in patients receiving antituberculosis treatment medication package (OAT) in the General Hospital of City of Kendari. This type of research is descriptive , Automatic method. Based on the results of 18 samples of normal platelet values ​​obtained on the duration of treatment 2-6 months as many as 15 people (83.3%), while acquired decreased platelet count (thrombocytopenia) in the old first month of treatment as many as three people (16.7%). Keywords :Tuberculosis lung, Anti tuberculosis drug, Platelet, RSUD Kendari city ABSTRAK Tuberkulosis (TB) adalah penyakit infeksi yang menyerang paru-paru yang disebabkan oleh kuman Mycobacterium tuberculosis yang penularannya melalui udara. Salah satu obat yang digunakan untuk penyakit TB yaitu rifampisin yang diketahui sebagai penyebab trombositopenia.Penelitian ini bertujuan untuk mengetahui gambaran nilai trombosit pada pasien tuberculosis paru yang mendapat perawatan paket obat anti tuberkulosis (OAT) di Rumah sakit Umum Daerah Kota Kendari. Jenis penelitian ini adalah deskriptif, pemeriksaan jumlah trombosit dilakukan menggunakan metode automatik.Berdasarkan hasil penelitian dari 18 sampel diperoleh nilai trombosit normal pada pasien dengan lama pengobatan 2-6 bulan sebanyak 15 orang (83,3%), sedangkan nilai trombosit tidak normal (trombositopenia) pada pasien dengan pengobatan 1 bulan sebanyak 3 orang (16,7%) . Kata kunci : Tuberkulosis paru, obat anti tuberkulosis, trombosit, RSUD Kota Kendari
SKRINING Human Immunodeficiency Virus (HIV) PADA IBU HAMIL TRIMESTER II DI PUSKESMAS WILAYAH KABUPATEN KONAWE UTARA Firdayanti Firdayanti; Sri Aprilianti Idris
Jurnal Analis Kesehatan Kendari Vol 4 No 1 (2021): Jurnal Analis Kesehatan Kendari (JAKK : Vol. 4 (1) Desember 2021)
Publisher : Program Studi Diploma III Analis Kesehatan Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.41 KB) | DOI: 10.46356/jakk.v4i1.171

Abstract

ABSTRAK Human Immunodeficiency Virus (HIV) adalah virus yang menyebabkan AIDS yang termasuk dalam kelompok retrovirus. AIDS adalah Acquired Immune Deficiency Syndrome. “Acquired” artinya tidak diturunkan, tetapi didapat; “Immune” adalah sistem daya tangkap atau kekebalan tubuh terhdap penyakit; “Deficiency” artinya tidak cukup atau kurang dan “Syndrome” adalah kumpulan tanda dan gejala penyakit. Lebih dari 90% anak terinfeksi HIV didapat dari ibunya. Virus dapat ditularkan dari ibu yang terinfeksi HIV kepada anaknya selama hamil, saat persalinan dan menyusui, HIV tidak ditularkan melalui bersalaman, berpelukan, bersentuhan atau berciuman, penggunaan toilet umum, kolam renang, alat makan atau minum secara bersama, ataupun gigitan serangga seperti nyamuk. Penelitian ini bertujuan untuk mengetahui hasil skrining HIV pada ibu hamil trimester II di puskesmas Kab Konawe Utara. Jenis penelitian ini adalah Observasional analitik dengan teknik pengambilan sampel bersifat accidental sampling, dengan jumlah sampel sebanyak 43 orang. Metode pemeriksaan yang digunakan adalah ICT (immunokromatografi)Rapid test/strip. Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa dari 43 pasien ibu hamil trimester II di puskesmas wilayah Kabupaten Konawe Utara yang telah dilakukan pemeriksaan Human Immunodeficiency Virus (HIV), didapatkan hasil negatif yaitu sebanyak 43 orang (100%).Kata kunci : HIV, Ibu hamil Trimester II ABSTRACT Human Immunodeficiency Virus (HIV) is the virus that causes AIDS which is included in the retrovirus group. AIDS is from Acquired Immune Deficiency Syndrome. "Acquired" means not derived, but obtained; "Immune" is a system of capture or immunity against disease; "Deficiency" means not enough or less and "Syndrome" is a collection of signs and symptoms of the disease. More than 90% of children infected with HIV are from their mothers. Viruses can be transmitted from HIV-infected mothers to their children during pregnancy, during labor and breastfeeding. Without proper and early treatment. It should be noted that, HIV is not transmitted through shaking hands, hugging, touching or kissing, using public toilets, swimming pools, eating utensils or drinking together, or insect bites such as mosquitoes. This study aims to determine the results of HIV screening in second trimester pregnant women in North Konawe Kab. This type of research is analytic observational with the sampling technique is accidental sampling, with a total sample of 43 people The examination method used is ICT (immunochromato graphy) Rapid test / strip. Based on the results of the research that has been done, it can be concluded that of 43 patients in the second trimester of pregnant women in the health center of North Konawe District who had been examined by Human Immunodeficiency Virus (HIV), negative results were obtained, namely 43 people (100%). Keywords : HIV, Trimester pregnant women
GAMBARAN KADAR KOLESTEROL TOTAL PENDERITA DIABETES MELLITUS DI RUMAH SAKIT BENYAMIN GULUH KOLAKA firdayanti Firdayanti; Angriani Fusvita; Irdayanti Irdayanti
Jurnal Analis Kesehatan Kendari Vol 4 No 2 (2022): Jurnal Analis Kesehatan Kendari (JAKK : Vol. 4 (2) Juni 2022)
Publisher : Program Studi Diploma III Analis Kesehatan Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.377 KB) | DOI: 10.46356/jakk.v4i2.186

Abstract

Diabetes mellitus is a hyperglycemia disease charactherized by absolute absence of insulin or a relative decrease in insulin insensitivity to insulin., diseases of the eyes, kidneys and nerves. Cholesterol and diabetes mellitus have a related , where factors that can increase total cholesterol (hyperglycemia), namely nutrition, drugs, obesity and age are also factors that cause a person suffering from diabetes mellitus. This study aims to determine the picture of total cholesterol levels in people with diabetes mellitus in Benyamin guluh hospital Kolaka. The sample taken in this study is the outpatient plasma at the Benyamin guluh hospital Kolaka that was diagnosed with diabetes mellitus. In this study the number of samples studied were 30 samples as many as 30 people were obtained by accidental sampling . The results of the study were from the examination of 30 patiens with diabetes mellitus at Benyamin Guluh Kolaka Hospital. Normal kolesterol result were 11 people (37%), and abnormal 19 people (30%). Keywords : Diabetes mellitus, Total cholesterol levels, Hyperglycemia
PROFIL KOLESTEROL TOTAL PADA PENDERITA PENYAKIT JANTUNG KORONER DI RUMAH SAKIT UMUM DAERAH KOTA KENDARI Ani Umar; firdayanti firdayanti; Nur Hijreah Samsu
Jurnal Analis Kesehatan Kendari Vol 5 No 1 (2022): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 5 (1) Desember 2022)
Publisher : Program Studi Diploma III Analis Kesehatan Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.678 KB) | DOI: 10.46356/jakk.v5i1.215

Abstract

Total Cholesterol profile in patients with coronary heart disease at the city general hospital in kendari”. Coronary heart disease is one of the three main causes of death in the world each years. PJK is a disease that arises due to narrowing or blockage of arteries that enter the bloodstream to the heart muscle so that there is a lack of oxygen supply to the heart muscle. Total cholesterol is the total amount of cholesterol in the blood. Examination of total cholesterol which is a blood test that functions to determine total cholesterol levels in patients with coronary heart disease. The purpose of this study was to determine the total cholesterol profile in patients with coronary heart disease in the general hospital area of the city of kendari with enzymatic kinetic methods. Samples of patients with coronary heart disease as many as 18 samples with sampling techniques namely accidental sampling. Based on the research that has been done obtained results that there are 5 people (27%) have level ≥ 200 mg/dL shows an increase in total cholesterol levels and 13 people (72%) have level ≤ 200 mg/dL showing normal cholesterol levels. Key Words : Coronary Heart Disease, Total Cholesterol, Examination of Total Cholesterol.
Pemeriksaan Kadar Asam Urat Pada Masyarakat Desa Puuwonua Kecamatan Andowia Muhammad Sultanul Aulya; Firdayanti Firdayanti; Angriani Fusvita; Apriyanto Apriyanto; Nurul Afdhaliyah Nurdin; Anggraeni Anggraeni; Niluh Eka Ayu Pratiwi
Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Vol 1 No 1 (2023): NADIKAMI: Januari 2023
Publisher : POLITEKNIK BINA HUSADA KENDARI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pentingnya kegiatan Pengabmas adalah untuk membantu masyarakat terutama masyarakat yang bergolongan menengah ke bawah untuk melakukan pemeriksaan penunjang penyakit kardiovaskuler yang sering diderita oleh masyarakat, tujuan kegiatan pengabdian masyarakat ini adalah untuk mengetahui hasil pemeriksaan kadar asam urat pada masyarakat di desa Puuwonua Kecamatan Andowia., Desain kegiatan ini menggunakan desain deskriptif observational yaitu menggambarkan hasil pemeriksaan asam urat berdasarkan hasil obervasi dilapangan. Dari kegiatan yang telah dilakukan diperoleh hasil pemeriksaan asam urat pada masyarakat Desa Puuwonua Kecamatan Andowia, dengan jumlah sampel 21 sampel maka diperoleh hasil pemeriksaan asam urat dengan jenis kelamin laki-laki, yang normal sebanyak 6 orang (100%). Sedangkan untuk jenis kelamin perempuan, yang normal sebanyak 12 (80%) orang dan yang mengalami hiperurisemia sebanyak 3 orang (20%).
Pemeriksaan Golongan Darah Dan Rhesus Pada Masyarakat Desa Puuwonua Kecamatan Andowia Angriani Fusvita; Muhammad Sultanul Aulya; Firdayanti Firdayanti; Apriyanto Apriyanto; Suci Devianti Ningsih; Niluh Eka Ayu Pratiwi; Anggraeni Anggraeni
Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Vol 1 No 2 (2023): NADIKAMI: Juli 2023
Publisher : POLITEKNIK BINA HUSADA KENDARI

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Abstract

Pengabmas adalah suatu kegiatan yang bertujuan untuk membantu masyarakat dalam beberapa aktivitas tanpa mengharapkan imbalan dalam bentuk apapun. Secara umum, program ini dirancang oleh berbagai Perguruan Tinggi yang ada di Indonesia untuk memberikan kontribusi nyata bagi bangsa, khususnya dalam mengembangkan kesejahteraan dan kemajuan bangsa Indonesia. Kegiatan pengabdian masyarakat menjadi salah satu bagian dari Tri Dharma Perguruan Tinggi. Tujuan kegiatan pengabdian masyarakat ini adalah untuk mengetahui hasil pemeriksaan golongan darah dan rhesus pada masyarakat di desa Puuwonua Kecamatan Andowia., Desain kegiatan ini menggunakan desain deskriptif observational yaitu menggambarkan hasil pemeriksaan golongan darah berdasarkan hasil observasi dilapangan. Pemeriksaan Golongan darah sistem ABO yang dilakukan di Desa Puuwonua diperoleh hasil golongan darah A sebanyak 33 orang, golongan darah B sebanyak 15 orang, golongan darah O sebanyak 25 orang, sedangkan untuk golongan darah AB sebanyak 4 orang.
ANALISIS KADAR ASAM URAT SERUM PADA INDIVIDU DENGAN GAGAL GINJAL KRONIK Firdayanti Firdayanti; Sri Aprilianti Idris; Andi Arfan
SENTRI: Jurnal Riset Ilmiah Vol. 2 No. 8 (2023): SENTRI : Jurnal Riset Ilmiah, Agustus 2023
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v2i8.1264

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Gagal ginjal kronik (GGK) merupakan perkembangan gagal ginjal yang progresif dan lambat, biasanya berlangsung selama beberapa tahun. Pada GGK terjadi penurunan fungsi ginjal secara bertahap dan bersifat ireversibel, dan terjadi kerusakan total fungsi ekskresi yang dapat menyebabkan terjadinya peningkatan kadar zat dalam serum, salah satunya adalah kadar asam urat. Kadar asam urat yang meningkat dalam darah hingga melewati batas normal akan menimbulkan rasa sakit atau nyeri pada persendian. Penelitian ini bertujuan untuk mengetahui analisis hasil pemeriksaan asam urat pada pasien GGK di RSUD Bahteramas Provinsi Sulawesi Tenggara. Jenis penelitian yang digunakan adalah observasional analitik dengan teknik pengambilan sampel secara accidental sampling. Jumlah sampel yaitu sebanyak 29 pasien GGK. Hasil penelitian terhadap 29 penderita GGK berdasarkan analisis statistik menggunakan uji korelasi diperoleh hasil nilai P=0,000 (P<0,05) yang artinya secara statistik menunjukkan adanya hubungan yang signifikan antara peningkatan kadar asam urat dengan penderita GGK.