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All Journal Journal of Health (JoH) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Anita Ratna Faoziyah
STIKES Al-Irsyad Al-Islamiyyah Cilacap
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker Anita Ratna Faoziyah; Wahyu Kurniawan
Journal of Health (JoH) Vol 4 No 2 (2017): Journal of Health - Juli 2017
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (931.757 KB) | DOI: 10.30590/vol4-no2-p68-74

Abstract

This research was done to study mangrove leaves (Rhizophora mucronata sp.) utilization in the Cilacap regency brackish waters. The research goal is to make nano emulsion from mangrove plants as an alternative to increase the economic value of mangrove. This research method has 2 phases. In the first phase, mangrove leaves was extracted using various solvent. In the second phase mangrove leaves extract was formulated as nano emulsion as anti-cancer treatment along as an alternative to increase mangrove leaves economic value. Extraction results of mangrove leaves using various solvent such as hexane, ethyl acetate and ethanol show that using ethanol p.a solvent with the young leaves of mangrove giving the highest amount extract as much as 18.24%. Mangrove leaves extract nano emulsion can be prepared using Self-Nano Emulsifying Drug Delivery System (SNEDDS) technique. The SNEDDS technique nano emulsion formulation started with 14 formulas. The best formula from this study was using Tween 80 : PEG 400 : Fish Oil as much as 6 ml: 1 ml: 1 ml dosage ratio. Using the best formula, it was added with 5 mg of mangrove leaves extract. The result test of Drug Loading, calculation of Emulsification Time and Dissolution test show that mangrove leaves extract has the potential to be used as an active substance anti-cancer on nano emulsion manufacturing.
Penentuan Karakteristik Minyak Ikan Sidat Hasil Nelayan Kabupaten Cilacap Sebagai Bahan Baku Sediaan Farmasi Terstandar Anita Ratna Faoziyah
Journal of Health (JoH) Vol 5 No 2 (2018): Journal of Health - July 2018
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (680.099 KB) | DOI: 10.30590/vol5-no2-p87-91

Abstract

Penentuan Karakteristik Minyak Ikan Sidat Hasil Nelayan Kabupaten Cilacap Sebagai Bahan Baku Sediaan Farmasi Terstandar
Optimalisasi Ektraksi Ikan Sidat Dengan Variasi Metode Ektraksi sebagai Bahan Baku Pembuatan Mikrokapsul Suplemen Kesehatan Jantung Anita Ratna Faoziyah; Elisa Issusilaningtyas
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.5895

Abstract

Ikan sidat merupakan ikan yang memiliki nilai gizi tinggi. Penelitian ini bertujuan mengetahui optimalisasi ektraksi ikan sidat dan formulasi pembuatan mikroenkapsul ektrak ikan sidat. Metode yang digunakan terdiri dari tiga metode ektraksi yaitu sokletasi, wet-, dan dry rendering. Rendemen ekstrak ikan sidat metode wet-, dry rendering, dan sokletasi masing-masing sebesar 0,019; 8,75; dan 2,41%. Karakteristik ekstrak ikan sidat metode wet rendering berupa minyak ikan dengan warna kuning, berbau amis khas minyak ikan, dengan kandungan air, bilangan peroksida, dan  bilangan asam sebesar 5,3%, 5,8 mg O2/gr, dan 2,8  mg NaOH/gr. Pada metode dry rendering ekstrak berwarna kuning keemasan, jernih dan berbau amis dengan bilangan asam sebesar 1,53 mg NaOH/gr, bilangan peroksida 61,44 mg O2/gr dan angka penyabunan sebesar 353,011 mg KOH/gr. Rendemen ekstrak ikan sidat dengan metode sokletasi berwarna coklat dengan bilangan peroksida sebesar 67,35 mg O2/gr dan bilangan asam 6,67 mg NaOH/gr. Ekstrak ikan sidat dapat dibuat mikroenkapsul kaya omega-3 sebagai suplemen kesehatan jantung koroner dengan formulasi ektrak ikan sidat 10%, amilum maydis 10%, primojel 4%, Mg Stearat - Talk (1 : 9) 1,5%, dan laktosa. Hasil formulasi menujukan kadar air 3,3%; waktu alir 7,23 gram/detik, sudut istirahat 25,44%, dan indeks pengetapan 9,30.
Co-Authors Elisa Issusilaningtyas Wahyu Kurniawan