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All Journal AcTion: Aceh Nutrition Journal Indonesian Journal of Medicine Nommensen Journal of Medicine Health Care : Jurnal Kesehatan Jurnal Visi Pengabdian Kepada Masyarakat
Jenny Novina Sitepu
Fakultas Kedokteran Universitas HKBP Nommensen
Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Indonesian Journal of Medicine

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Comparison of β-Hydroxylase Enzyme 11 Serum in Obese, Overweight, and Normoweight Young Men Sitepu, Jenny Novina; Sari, Mutiara Indah; Tann, Gino
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Previous studies showed that cardiovascular risk factor was increased in obese and overweight subjects. Obesity and cardiovascular risk factor are associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity that causes hypercortisolism, cortisol level is associated with cardiovascular risk factor on obesity. 11 β-hydroxylase is an enzyme that involved in cortisol synthesis. The aim of this study was to investigate 11 β-Hydroxylase concentration in obesity, overweight, and normal weight young men.Subjects and Method: This was analytic-observational study using cross-sectional design. The study was conducted at HKBP Nommensen University, Medan. The study subjects included by 76 young men aged 18-28 years old, consisting of 25 obese subjects, 25 overweight, and 25 normoweight. The concentration of 11 β-Hydroxylase was evaluated in blood sample after 10 hours fasting. The data was analyzed bivariately.Results: Mean of 11 β-Hydroxylase concentration was 52.76 ± 44.27 in obese subjects, 70.16 ± 46.83 in overweight subjects, and 43.42 ± 27.75 in normoweight subjects. The 11 β-Hydroxylase concentration in overweight subjects was statistically higher than normoweight subjects (p = 0.007), but the 11 β-Hydroxylase concentration on obese subjects statistically was not different from normoweight subjects (p = 0.362).Conclusion: The 11 β-Hydroxylase concentration on overweight subject is higher than normoweight subject. There is no difference of 11 β-Hydroxylase concentration on obese and normoweight subject. Mitochondrial stress and mitochondrial failure mechanism on overweight and obesity merit further investigation.Keywords: 11 β-Hydroxylase, cortisol, obesity, overweightCorrespondence: Jenny Novina Sitepu. Faculty of Medicine, HKBP Nommensen Medan University, Medan.Indonesian Journal of Medicine (2016), 1(1): 71-75https://doi.org/10.26911/theijmed.2016.01.01.09
Co-Authors Hendra Jirwanto Jianni Herawaty Sinaga Johan C Silaen Kristian David Pasaribu Leonardo Basa Dairy Miter Elidanovan Harefa Priparty Intan Sukma Siringoringo Reinata Gracia Hutahaean Rosminta Girsang Rosminta Girsang Runggu Retno J. Napitupulu Sarah Naomi Irianty Batubara Sari, Mutiara Indah Simanjuntak, Novita Hasiani Sisca Silvana Tann, Gino Yola Anggika Surbakti