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Tiangsa Sembiring
Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera
Health Professions Medicine & Pharmacology

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Body mass index, atopy, and allergic diseases Afnita Lestary; Lily Irsa; Tiangsa Sembiring; Rita Evalina; Meiviliani Sinaga
Paediatrica Indonesiana Vol 56 No 4 (2016): July 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.382 KB) | DOI: 10.14238/pi56.4.2016.221-5

Abstract

Background Prevalence of atopy, allergic diseases, and obesity are increasing. Atopy is an individu and/or familial tendency to sensitization in response to ordinary exposure to allergens. Studies on association of BM I with atopy and allergic diseases in children were limited, with inconclusive results. Objective To assess associations of BM I with atopy and allergic diseases in chidren. Methods A cross-sectional was conducted in school children aged 6-12 years in Lhokseumawe City, Aceh, June 2012. Children were assessed for BMI, skin prick test, and International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Statistical analyses included Chi-square, Fisher exact, and logistic regression. Results The subjects consisted of 137 (85.6%) normoweight, 12 (7.5%) overweight, and 11 (6.9%) obesity. Skin prick test results were positive in 44 (27.5%) and negative in 116 (72.5%) subjects. Allergic manifestations were allergic rhinitis (AR) 17 (10.6%), bronchial asthma 6 (3.8%), and atopic dermatitis (AD) 3 (1.9%). There was significant association of obesity with atopy, compared with normoweight (OR=3.78; 95%CI 1.08 to 13.19; P=0.037), but no significant association found when family history of atopy also assesed. There was significant association of obesity with bronchial asthma (OR=9.92; 95%CI 1.46 to 67.18; P=0.004) and AR (OR=6.49; 95%CI 1.64 to 25.66; P=0.015), compared with normoweight children. Significant association of overweight with atopy and allergic disease were not found. Conclusion Obese children are more likely to have atopy, bronchial asthma, and allergic rhinitis, but overweight and normoweight children are not.
Obesity and functional constipation in children Natasha Yuwanita; Atan Baas Sinuhaji; Tiangsa Sembiring; Supriatmo Supriatmo; Ade Rachmat Yudiyanto
Paediatrica Indonesiana Vol 58 No 1 (2018): January 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.628 KB) | DOI: 10.14238/pi58.1.2018.1-4

Abstract

Background Functional constipation is a common pediatric problem in both developed and developing countries. In the past two decades, the prevalence of obesity has increased worldwide. Obesity itself leads to many health problems, including functional constipation. Studies correlating obesity to functional constipation have thus far mostly originated from developed countries. Objective To assess for a possible correlation between obesity and functional constipation in children in a developing country. Methods This cross-sectional study was conducted in Al-Mukhlisin Islamic Boarding School, Batu Bara District, North Sumatera Province, Indonesia, between July and August 2015. The subjects were 150 students aged 12 to 17 years. Questionnaires were used to determine functional constipation and filled by direct interview. Obesity was determined by body mass index. Data were analyzed using Chi-square test. Results Of 150 children, 49 had functional constipation; and 18 of the 49 were obese. The mean age of children with constipation was 14.7 (SD 1.07) years (95%CI 14.1 to 14.7) and their mean body weight was 53.8 (SD 15.10) kg (95%CI 49.4 to 58.1). The prevalence for functional constipation in obese children was  58% There was a statistically significant correlation between obesity and functional constipation (prevalence ratio=4; 95%CI 1.72 to 8.94; P=0.001), indicating that obese children had 4 times higher risk of having functional constipation. Conclusion There is a significant correlation between obesity and functional constipation in children.
Albendazole versus combined pyrantel pamoate-mebendazole in the treatment of mixed infection of soil-transmitted helminthiasis Tiangsa Sembiring; Evi Kamelia; T. Ernalisna; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 42 No 11-12 (2002): November 2002
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi42.6.2002.268-72

Abstract

Background Soil transmitted helminthiasis is still highly prevalent in Indonesia, especially in rural area and among poor socio-economic population. Helminthiasis is frequently found as a single or mixed infection. It is difficult to get a medication with better efficacy, low cost, and simple administration for all types of worms.Objective The aim of this sudy was to compare the effectiveness of albendazole and pyrantel pamoate-mebendazole combination in treating soil-transmitted helminthiasis.Methods A randomized clinical trial was perionned in September until November 1995 on students of a primary school in Tanjung Anom Village whose stool examinations showed mixed infection of helminthiasis. Subjects were randomly allocated into two groups. The A group was treated with 400 mg oral albendazole as a single dose, while the B group was treated with the combination of pyrantel pamoate 10 mg/kg body weight as a single dose and mebendazole 100 mg twice a day for three consecutive days. Cure was considered if in the stool examination, no wonn eggs were found. Statistical analysis was periormed by Chi-square test with confidence interval of 95% and p value of < 0.05 was considered significant.Results Out of 541 children, mixed infection of soil-transmitted helminthiasis was found in 374 children (69%). Three hundreds sixty-six children completed the study, consisted of 182 children in group A and 184 in group B. At 3 weeks after treatment, the cure rate in the A group was significantly better compared to that in B group.Conclusions Albendazole was more effective than the combination of pyrantel pamoate - mebendazole for treating mixed infection of soil-transmitted helminthiasis. Besides the administration was simpler and caused minimal side effect.
Association between oxygen saturation and critical congenital heart disease in newborns Lidia Halim; Muhammad Ali; Tiangsa Sembiring
Paediatrica Indonesiana Vol 58 No 2 (2018): March 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.124 KB) | DOI: 10.14238/pi58.2.2018.90-4

Abstract

Background Critical congenital heart disease (CCHD) is relatively common, with a prevalence of 6-8 in every 1,000 live births. This congenital anomaly is a newborn condition that would be ideally suited for a screening program, if simple and reliable methods were available. Pulse oximetry (PO) has been proposed as a screening method to detect CCHD. Objective To assess for a possible association between decreased oxygen saturation and CCHD in newborns. Methods We conducted a cross-sectional study from March 2014 to February 2015 in several hospitals in North Sumatra. Healthy, full term and post-term newborns aged 2 to 72 hours underwent pulse oximetry measurements on the right hand and one of the lower extremities. If oxygen saturation (SpO2) was ≤ 95%, the measurement was repeated 2 more times. Subjects also underwent echocardiography. Results A total of 386 newborns underwent SpO2 measurements: 377 newborns had SpO2 > 95% and 9 newborns had SpO2 ≤ 95%. Of the infants with SpO2 > 95%, 297 were excluded because their parents refused echocardiography examination. Thus, 80 newborns with SpO2 > 95% and 9 newborns with SpO2 ≤ 95% underwent echocardiography. Echocardiography revealed that 5 of 9 newborns with SpO2 ≤ 95% suffered from Tetralogy of Fallot (ToF) (3 subjects) and transposition of the great arteries (TGA) (2 subjects). One infant with SpO2 > 95% had ventricular septal defect (VSD), as detected by echocardiography. Oxygen saturation ≤ 95% had significant association with CCHD (P<0.001). Conclusion Decreased oxygen saturation has a significant association with critical congenital heart disease in newborns.
Randomized Trial of Albendazole with Combination of Pyrantel Pamoate-Mebendazole in Treatment of Mixed Helminthiasis in Children Tiangsa Sembiring; Evi Kamelia; T. Ernalisna; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 39 No 5-6 (1999): May - June 1999
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4071.42 KB) | DOI: 10.14238/pi39.5-6.1999.163-71

Abstract

This study aimed to compare the effectiveness of albendazole and pyrantelpamoate-mabendazole combination for the treatment of mixed infection of soil transmitted helminthiasis. Subjects were students of primary school in Tanjung Anom village, North Sumatra. The study was performed from September until November 1995. Pat.ients were randomired into two groups; Group A received 400 mg oral albendazole in single dose while group B recieved a combination of pyrantel pamoate 10 mg/kg BW as a single dose and mebendazole 2 x 100 mg in three consecutive days.From 541 children examined, mixed soil transmitted helmlnthiasis was found in 374 children (69%). Analysis was performed on 182 children in Group A and 184 in Group B. Comparison between two group, cure rate at 3 weeks after treatment proved to the significantly different (p<0.05). We conclude that albendawle was more effective than combination of pyrantel pamoate- mebendawle for the treatment of mixed infection of soil transmitted helminthiasis. Administration more simple and have minimal side effect.
Co-Authors Ade Rachmat Yudiyanto Afnita Lestary Atan Baas Sinuhaji Chairuddin P. Lubis Evi Kamelia Lidia Halim Lily Irsa Meiviliani Sinaga Muhammad Ali Natasha Yuwanita Rita Evalina Supriatmo Supriatmo Syahril Pasaribu T. Ernalisna