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Evi Kamelia
Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera
Health Professions Medicine & Pharmacology

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Albendazole versus combined pyrantel pamoate-mebendazole in the treatment of mixed infection of soil-transmitted helminthiasis Tiangsa Sembiring; Evi Kamelia; T. Ernalisna; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 42 No 11-12 (2002): November 2002
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi42.6.2002.268-72

Abstract

Background Soil transmitted helminthiasis is still highly prevalent in Indonesia, especially in rural area and among poor socio-economic population. Helminthiasis is frequently found as a single or mixed infection. It is difficult to get a medication with better efficacy, low cost, and simple administration for all types of worms.Objective The aim of this sudy was to compare the effectiveness of albendazole and pyrantel pamoate-mebendazole combination in treating soil-transmitted helminthiasis.Methods A randomized clinical trial was perionned in September until November 1995 on students of a primary school in Tanjung Anom Village whose stool examinations showed mixed infection of helminthiasis. Subjects were randomly allocated into two groups. The A group was treated with 400 mg oral albendazole as a single dose, while the B group was treated with the combination of pyrantel pamoate 10 mg/kg body weight as a single dose and mebendazole 100 mg twice a day for three consecutive days. Cure was considered if in the stool examination, no wonn eggs were found. Statistical analysis was periormed by Chi-square test with confidence interval of 95% and p value of < 0.05 was considered significant.Results Out of 541 children, mixed infection of soil-transmitted helminthiasis was found in 374 children (69%). Three hundreds sixty-six children completed the study, consisted of 182 children in group A and 184 in group B. At 3 weeks after treatment, the cure rate in the A group was significantly better compared to that in B group.Conclusions Albendazole was more effective than the combination of pyrantel pamoate - mebendazole for treating mixed infection of soil-transmitted helminthiasis. Besides the administration was simpler and caused minimal side effect.
Randomized Trial of Albendazole with Combination of Pyrantel Pamoate-Mebendazole in Treatment of Mixed Helminthiasis in Children Tiangsa Sembiring; Evi Kamelia; T. Ernalisna; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 39 No 5-6 (1999): May - June 1999
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4071.42 KB) | DOI: 10.14238/pi39.5-6.1999.163-71

Abstract

This study aimed to compare the effectiveness of albendazole and pyrantelpamoate-mabendazole combination for the treatment of mixed infection of soil transmitted helminthiasis. Subjects were students of primary school in Tanjung Anom village, North Sumatra. The study was performed from September until November 1995. Pat.ients were randomired into two groups; Group A received 400 mg oral albendazole in single dose while group B recieved a combination of pyrantel pamoate 10 mg/kg BW as a single dose and mebendazole 2 x 100 mg in three consecutive days.From 541 children examined, mixed soil transmitted helmlnthiasis was found in 374 children (69%). Analysis was performed on 182 children in Group A and 184 in Group B. Comparison between two group, cure rate at 3 weeks after treatment proved to the significantly different (p<0.05). We conclude that albendawle was more effective than combination of pyrantel pamoate- mebendawle for the treatment of mixed infection of soil transmitted helminthiasis. Administration more simple and have minimal side effect.
Co-Authors Chairuddin P. Lubis Syahril Pasaribu T. Ernalisna Tiangsa Sembiring