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Lily Emsyah
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Health Professions Medicine & Pharmacology

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Comparison of the effect of oral multiple dose with single intramuscular vitamin K1 administration on prothrombin time in term baby Nancy Ervani; Bugis M. Lubis; Emil Azlin; Guslihan D. Tjipta; Lily Emsyah
Paediatrica Indonesiana Vol 49 No 5 (2009): September 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.26 KB) | DOI: 10.14238/pi49.5.2009.281-5

Abstract

Background Vitamin K deficiency can cause bleeding disorders inhealthy breastfed infants. The efficacy of newborn intramuscularvitamin K prophylaxis for the prevention of this bleeding problemhas been well established, but this is an invasive procedure. Oralvitamin K prophylaxis is more effective, less expensive, and lesstraumatic than intramuscular administration.Objective To compare prothrombin time (PT) after theadministration of oral multiple dose vitamin K1 with that afteran intramuscular preparation.Methods Infants were randomised at birth into the intramuscular(IM) group (1 mg vitamin K1) and the oral group (2 mg given atbirth and repeated at day 3). PT was monitored before and afterthe administration of vitamin K1.Results Thirty six of 70 infants received oral vitamin K1. MeanPT (SO) before vitamin K1 administration was 36.34 (SO 20.03)seconds in oral group and 31.96 (SO 25.51) seconds in IM group, PT changes after vitamin K1 administration were 16.29 (SO 15.46) seconds in oral group and 11.58 (SO 10.62) seconds in IM group, it did not differ significantly (P=0.203).Conclusion Prothrombin time changes are not significantlydifferent between oral vitamin K1 and IM group.
Efficacy of 10% povidone iodine versus 70% alcohol in umbilical cord care of newborn infants Rasyidah Rasyidah; Yulizar Yulizar; Lily Emsyah; Guslihan D Tjipta; Dachrul Aldy
Paediatrica Indonesiana Vol 45 No 5 (2005): September 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.5.2005.198-202

Abstract

Objective To compare the effectiveness of 10% povidone iodineto that of 70% alcohol in umbilical cord care of newborn infants.Methods This open label clinical trial was conducted in PirngadiHospital, Medan from July to September 2003. Newborn infantswho fulfilled inclusion criteria were randomly allocated to umbili-cal cord care using 10% povidone iodine or 70% alcohol. Themain outcome measures were omphalitis prevalence, microor-ganism colonization, and time to umbilical cord separation. Cultureof the umbilical cord swab was taken in the first 48-72 hoursafter birth. The umbilical cord was observed daily during hospital-ization and every other day after discharge until cord separation.Statistical analysis was done using chi-square test and indepen-dent t-test.Results There were 54 infants in the povidone iodine group and52 infants in the alcohol group. Omphalitis was absent in bothgroups. Fourteen percent of subjects in the povidone iodine groupshowed no microorganism growth, compared to 7% in the alco-hol group. Staphylococcus aureus colonization was found in10% of subjects in the povidone iodine group and 23% of sub-jects in the alcohol group. The prevalence of Escherichia colicolonization was 41% and 47% in the povidone iodine and alco-hol groups, respectively. There was no statistically significantdifference between both groups in bacterial colonization (P=0.135).Mean time to umbilical cord separation was 6.44 days in thepovidone iodine group and 6.13 days in the alcohol group(P=0.431).Conclusion These results suggest that 10% povidone iodineand 70% alcohol are equally effective in umbilical cord care ofnewborn infants
Co-Authors Bugis M. Lubis Dachrul Aldy Emil Azlin Guslihan D Tjipta Guslihan D. Tjipta Nancy Ervani Rasyidah Rasyidah Yulizar Yulizar