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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Paediatrica Indonesiana Jurnal Respirasi (JR) Indian Journal of Forensic Medicine & Toxicology
Azwin Mengindra Putera
Airlangga University Surabaya, Dr Soetomo General Hospital Surabaya
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Profile of Determinant Factors on Drug Allergy Severity in Indonesian Children at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia Bagas Triambodo; Azwin Mengindra Putera; Bambang Hermanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14671

Abstract

Background: Drug allergy in children is a rare case that needs special attention. Identifying the factorsthat affect the severity of drug allergy is important for the improvement of drug allergy management inIndonesian children. Objective: to analyze the factors that influence drug allergy severity in Indonesianchildren. Methods: This study used a retrospective design and consecutive sampling in 2014-2018. The datacollected included sex, types of allergy-causing drugs, previous allergy history, parental allergy history, andclinical manifestations. The data were analyzed by using a logistic regression test where the statistical testresults were significant if p <0.05. Results: The average age of the participants was 93.00 ± 50.54 monthswith a median value of 84 (12 - 204) months. Drug allergy severity in children is influenced by severalthings, such as the type of drug (? = 5.76; 95% CI 1.29 - 25.70; p = 0.022), sex (? = 1.27; 95% CI 0.30 - 5.36;p = 0.743), previous allergy history (? = 2.44; 95% CI 0.10 - 58.67; p = 0.583), and a drug allergy history onparents (? = 0.65; 95% CI 0.06 - 6.75; p = 0.719). Conclusion: There is a significant relationship betweendrug allergy severity and the type of drug whereas sex, previous allergy history, and a history of allergy onparents do not find a significant connection.
Immunotherapy Duration and Risk of Psychosocial Emotion and Risk of Attention Deficit Hyperactivity Disorder Prevalence and Relation in Allergic Rhinitis Children Dinda Anes Tunjungsari; Anang Endaryanto; Ahmad Suryawan; Ariyanto Harsono; Zahrah Hikmah; Azwin Mengindra Putera
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14707

Abstract

Background: Allergic rhinitis (AR) is the most common chronic disease in children. Allergic symptomsaffect daily activities and increase risk of psychosocial emotion and attention deficit hyperactivity disorder(ADHD). Immunotherapy has been proven in improving AR symptomsObjective: To identify prevalence of the risk of psychosocial emotion disorder and ADHD and its relationwith immunotherapy duration in AR children.Methods: A cross-sectional study was held in AR children aged 4-18 years at Allergy Immunology OutpatientClinic, Dr. Soetomo Hospital, during March 2017. Immunotherapy duration categorized into 0-6 months, 6months-1 year, 1-2 years, 2-3 years. Psychosocial emotion disorder risk assessed using Pediatric SymptomsChecklist 17 (PSC-17), scored into four different subscales: Internalizing, Externalizing, Attention, andTotal Score. ADHD risk was assessed using Abbreviated Conner’s Rating Scale (ACRS). Statistical analysisusing One-Way ANOVA and Eta test, with a value of p< 0.05 considered as significant.Results: Total of 37 children included. Based on immunotherapy duration 0-6 months, 6 months-1 year, 1-2years, and 2-3 years, prevalence risk of ADHD are 20.6%, 15.4%, 12.5%, and 12.5%, and prevalence ofpsychosocial emotion disorder risk are only in immunotherapy duration 6 months-1 year 12.5%. There wereno correlation between immunotherapy duration with risk of psychosocial emotion disorder (p = 0.945) andsignificantly correlated to ADHD (p = 0.049, r = 0.326).Conclusion: Prevalence risk of ADHD decrease as the immunotherapy duration increase and immunotherapyduration weakly correlated with risk of ADHD.
Correlation of Age, Sex, and Symptoms to Number of Problematic Joints in Children with Idiopathic Juvenile Arthritis Made Retna Paramita Savitri; Azwin Mengindra Putera; Noor Idha Handajani
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14791

Abstract

Background: Juvenile Idiopathic Arthritis (JIA) is a rare case in Asia, including Indonesia. Objective:Analyze the correlation between age, sex, and symptoms on the number of joint problems in children withJIA symptoms. Methods: This study used a retrospective design from January 2016 to December 2019.The data collecting in this study was included age, sex, symptoms, and the number of joint problems. Theanalysis used was multiple linear regression with p <0.05. Results: The correlation between sex (? = 0.015;95% CI -0.002 – 0.002; p = 0.916), age (? = 0.015; 95% CI -0.197 – 0.291; p = 0.916) to the number ofjoint problems was not significant. While, the correlation between symptoms and the number of joints withproblems was significant, which included swelling (? = 1.012; 95% CI 0.243 – 1.782; p = 0.011), fever(? = 1.000; 95% CI 0.082 – 1.918; p = 0.034), and pain. (? = 0.931; 95% CI 0.082 – 1.918; p = 0.007).Conclusion: There is a significant relationship between symptoms and the number of problem joints whileage and sex are not significant
Food allergies in children: a comparison of parental reports and skin prick test results Camilia Metadea Aji Savitri; Azwin Mengindra Putera Lubis; Gatot Soegiarto
Paediatrica Indonesiana Vol 58 No 2 (2018): March 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.752 KB) | DOI: 10.14238/pi58.2.2018.59-65

Abstract

Background Food allergy is common in children and its prevalence is generally on the rise. Imprecise parental reports about reactions to particular foods can lead to unnecessary restrictions. Since children have specific growth requirements, such nutritional restrictions may have disturbing effects on children's growth and development. Objective To compare parental reports on food reactions to skin prick test results in their children. Method Retrospective, cross sectional study using patient's medical record data during one-year study period. Data were analyzed manually and statistically, to assess the degree of agreement (Kappa's coefficient) and significance (P). Results We collected data from 154 subjects aged 0-18 years. For every allergen assessed, parents reported more food reactions than positive skin prick test results. Allergy incidence were caused, in order, by cow's milk and chicken (25.3%), eggs (22.1%), chocolate (20.1%), fruits (14.3%), seafood (13%), and saltwater fish (1.9%). Kappa coefficient are all poor (<0.2) and P value are all >0.05 except for chicken (P=0.02). Conclusion Most parents tend to overestimate which food cause reactions in their children, as reactions reported were not necessarily allergenic. Therefore, every patient experiencing allergy reactions should undergo skin prick testing to confirm the possibility of allergy.
Age and Nutritional Status as Factors Supporting Incidence of Atopic Dermatitis with Complications in Children: A Retrospective and Cross-Sectional Study Khansa Raihani Rosmalika; Damayanti Damayanti; Azwin Mengindra Putera
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.81-85

Abstract

Background: AD is a chronic, pruritic inflammatory skin disease that frequently occurs and common in infants and children. Purpose: This study aims to analyze the correlation of age, sex, nutritional status, and family history of atopy with the occurrence of AD complications in children. Methods: This study used a cross-sectional study design in pediatric AD patients aged 0-18 years. Data were collected from electronic medical records (EMR) of pediatric AD patients at the Dermatology Outpatient Clinic of  Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2019. The bivariate analysis in this study used the Chi-square test. The statistical test was significant, as indicated by p-value (p < 0.05). Result: Out of 80 eligible participants, a total of 53.75% of the participants were children aged 1-60 months, and 55% of total were female. In this study, 28.75% of participants had normal nutritional status. A total of 67.5% of patients had no family history of atopy. There was a significant relationship between age and nutritional status with the incidence of AD with complications (p=0.006 and 0.040), but no relation was found between sex and family history of atopy (p=0.444 and 0.644). Conclusion: Age and nutritional status have a correlation with the incidence of AD with complications.
Second-Hand Smoke and Early Allergic Manifestation in Children Sitisalma Amirah Dzakiyyah; Anang Endaryanto; Linda Dewanti; Azwin Mengindra Putera; Anisa Ayu Maharani
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.634 KB) | DOI: 10.20473/jr.v8-I.3.2022.126-132

Abstract

Introduction: The interaction between genetic and environmental factors plays an important role in shaping the early development of allergies, including exposure to cigarette smoke. This study aimed to determine the relationship between second-hand smoke exposure and early allergic manifestations in children. Methods: This was an observational analytic study with a cross-sectional design. Pediatric patients who suffered from allergies in the allergy outpatient clinic at the Department of Pediatrics, Dr. Soetomo General Hospital, Surabaya were included in this study. Data were obtained through medical records. Results: This study involved 190 patients and showed that 50% of the patients have families who smoke at home, the most common early manifestations were at 11-20 months old (32.10%), and the most common early manifestations were respiratory manifestations (98.42%). There was a significant relationship between the presence of a family member who smoked at home with the age of early manifestation, respiratory manifestation, and skin manifestation in allergic pediatric patients (all p < 0.05). There was no significant relationship between the presence of family members who smoked at home with gastrointestinal manifestations in allergic pediatric patients (p = 0.301). Conclusion: There was a significant relationship between the presence of family members who smoke at home with age, respiratory tract, and skin manifestations in allergic pediatric patients.
Co-Authors Ahmad Suryawan Anang Endaryanto Anang Endaryanto Anisa Ayu Maharani Ariyanto Harsono Bagas Triambodo Bambang Hermanto Camilia Metadea Aji Savitri Damayanti Damayanti Dinda Anes Tunjungsari Gatot Soegiarto Khansa Raihani Rosmalika Linda Dewanti Made Retna Paramita Savitri Noor Idha Handajani Sitisalma Amirah Dzakiyyah Zahrah Hikmah, Zahrah