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All Journal journal of internal medicine Jurnal Kedokteran Brawijaya Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Penyakit Dalam Indonesia

Gatot Soegiarto

Allergy & Clinical Immunology Division, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya

Author-ID : 3289438

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Medicine & Pharmacology Neuroscience Public Health Other

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IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2006.144 KB)

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as âfluâ. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

ASOSIASI ANTARA POLUSI UDARA DENGAN IgE TOTAL SERUM DAN TES FAAL PARU PADA POLISI LALU LINTAS Fahimi, Mukti; Dharma S, Bayu; Fetarayani, Deasy; Baskoro, Ari; Soegiarto, Gatot; Effendi, Chairul
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.192 KB)

Ambient air pollution often associated with allergic diseases and impaired respiratory function. Total serum IgE levels was one of the diagnostic tools to establish an allergic diseases while lung function test was standard examination to establish alteration in lung function. Trafc police ofcers were often assigned on the highway is one of the mostvulnerable population against exposure to air pollution. Aim of this study isto know the association between air pollution on total serum IgE levels and lung function in trafc police ofcers compared to staff police ofcer as control.This is anobservational analysis study with cross sectional design.There were 60 police ofcers as a subject, divided in two groups.Thirty subjects as exposured groups and 30 subjects as control group. Air pollution was measured by Pollutant StandardIndex (PSI)/ Indeks Standar Pencemar Udara (ISPU) method. Independent t-test and Mann-Whitney test were used to analyze differences between variabel. Spearman test was used to analyze correlation and strength between variabel.There were no signicant differences in total IgE serum levels between groups (p = 0.301). There were signicant differencesin FEV1 (%p) (p = 0.015), FVC (%p) (p = 0.000) and spyrometry result (p = 0.001). There was no signicant differencein FEV1/FVC ratio (p = 0.573). There were negative weak association between air polution and FEV1 (%p) (r = -0.298;p=0.021) and between air pollution and spyrometry result (r = -0.380; p = 0.003). There was negative moderate associationbetween air pollution and FVC (%p) (r = -0.409; p = 0.001). There was no association between air pollution and FEV1/FVC ratio (r = 0.058; p = 0.662). There was signicant association between air pollution and impaired respiratory functionbut there was no association between air pollution and total serum IgE levels.

Macrophage Activity and Histopathological Differences of Lung Tissue on Sequential Co-infections of Heligmosomoides Polygyrus Nematode on Mycobacterium Tuberculosis Infection Laksmi Wulandari1.2, Muhammad Amin1, Soedarto3, Gatot Soegiarto2.4, Kenji Ishiwata5
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3181

Background: Tuberculosis is a chronic infection caused by Mycobacterium tuberculosis, a facultative intracellular parasite, that can be eliminated by cellular immunity played by macrophages. It has become a debate whether the co-infection of nematodes will affect the immune response of macrophages towards mycobacterium infection. Objective: To reveal macrophage activity and histopathological difference of lung tissue in sequential coinfection of Heligmosomoides Polygyrus towards Mycobacterium tuberculosis infection. Method: This study used 49 mice divided into 7 treatment groups with Mycobacterium tuberculose infection by inhalation and Heligmosomoides polygyrus orally within 8 and 16 weeks, and observed by immunohistochemical staining. Result: Infection for 8 weeks showed polarization of macrophages towards M1 macrophage, whereas in 16 weeks, the macrophage polarization more towards M2 macrophages, supported by histopathological changes of lung tissue: peribronchiolitis, perivaskulitis, alveolitis, and granuloma formation with counts of acid-resistant germs +3. There was a difference of expression of arginase1 to each group (p <0.001) and there was a difference of T CD4+ Th1 lymphocyte (p <0.001). Conclusion: There is a difference in macrophage activity in lung tissue; however, it does not cause different levels of histopathological changes in lung tissue and does not affect the immune response to Mycobacterium tuberculosis infection.

Response Evaluation on Single Common and Uncommon EGFR Mutation on First-Generation EGFR-TKI Therapy in NSCLC Patients Rena Arusita Maranatha1 , Laksmi Wulandari2 , Gatot Soegiarto3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13423

Objective: To compare the response of first-generation EGFR-TKI (epidermal growth factor receptortyrosine kinase inhibitors) in non-small cell lung cancer (NSCLC) patients with single common anduncommon EGFR mutation.Methods: Patients were divided into two groups, the uncommon (exon 21 L861Q, exon 18 G719X, exon18 delE709) and common EGFR mutation group (exon 19 deletion, exon 21 L858R). Health-related qualityof life (HRQOL) using EuroQol EQ-5D® questionnaire, body weight, performance status (PS), ResponseEvaluation Criteria in Solid Tumors (RECIST) on chest CT, progression-free survival (PFS) and overallsurvival (OS) was recorded during TKI therapy.Results: The value of HRQOL was stable and PS was constant in both groups, body weight was constantin uncommon group (42.1%) and increased in common group (44.1%; p=0.165). The uncommon groupshowed mostly progressive disease in RECIST (47.4%) while the common group showed mostly partialresponse (42.2%; p=0.007). PFS in the uncommon group was 4 (2.0-6.0) months and 7.0 (2.0-21.0) monthsin the common group (p=0.001). OS in the uncommon and common group were 4.00±1.71 months and10.00±6.94 months (p<0.001), respectively.Conclusion: NSCLC patients with common EGFR mutations showed a better response and survival ratecompared to uncommon EGFR mutations on first-generation TKI therapy.

Three Characterisctics of Atopy to Diagnose Allergy in Children with Respiratory Symptomps Far-Far, Imanuel; Endaryanto, Anang; Setyoningrum, Retno Asih; Soegiarto, Gatot
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.9

The prevalence of allergic diseases has increased in the last decade. Therefore, precise and reliable in predicting allergy in children were needed. However, in daily practice, most misdiagnosis occurs because it is only based on a family history of allergy. This study aims to evaluate the chronicity, recurrence of symptoms with similar exposure, and family history of allergy to be used as a predictor of allergy in children with respiratory symptoms. Cross sectional study was conducted in children who referred to the Pediatric Allergy and Immunology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 1st - July 31st 2019. Children with a suspected allergy who developed respiratory symptoms was included. The data was taken from standardized medical record. The sensitivity and specificity of the 3 characteristics of atopic with positive SPT were calculated. A total of 115 children were admitted and 109 children fulfill the inclusion criteria. Gender 60% male and 40% female. The most common group of age founded was age 5-<10 years 39.4%, followed by 1-<3 years (25.8%), 3-<5 years (22.9%), 10 years 8.3%, and <1 year (3.6%). Fifty-four patients (49.5%) fulfilled 3 characteristics of atopy and there were 64 patients (58.7%) with positive SPT results. The sensitivity, specificity, positive predictive value and negative predictive value were 81.3%, 95.6%, 96.3%, and 78.2%, respectively. The 3 characteristics of atopy have good sensitivity and specificity to predict allergy in children.

Comparison of the Efficacy of Generation 1 and 2 Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Patients with EGFR Positive Mutations Suwandi; Laksmi Wulandari; Gatot Soegiarto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15970

Background: The use of TKI generation 1 (Gefitinib, Erlotinib) and Generation 2 (Afatinib) has become thestandard therapy for JPIC pulmonary adenocarcinoma type with positive EGFR gene mutations.Objective: to analyze the comparison of the efficacy of TKI generation 1 and 2 in NSCLC patients withpositive EGFR mutations.Methods: The design of this study used a retrospective in which the participants who received EGFR therapyfor TKI generations 1 and 2 were compared its efficacy. Data collected included health-related quality of life(HRQOL), body weight, performance status (PS), Response Evaluation Criteria in Solid Tumors (RECIST)of thoracic CT, Common Terminology Criteria for Adverse Events (CTCAE), progression free survival(PFS) and overall survival (OS). The statistical analysis used was the independent t test, Mann Whitney test,or Kruskal Wallis test with p <0.05.Results: Most of the participants’ quality of life scores did not change before and after therapy, where theEQ5D value was 67.5% (group 1 = 60.6%; Group 2 = 94.1%; p = 0.806). The participant’s weight decreasedby 49.5% (group 1 = 45.9%; group 2 = 60.0%; p = 0.658) and the participant’s PS was stable (group 1 =29.4%; group 2 = 50.0%; p = 0.014). The RECIST value of the participant was progressive disease 51.0% (p= 0.338). CTCAE differed in stomatitis (p <0.001), paronychia (p <0.001), and diarrhea (p <0.001). Therewas no significant difference between the first and second groups in the PFS (p = 0.197) and OS (p = 0.740)values.Conclusion: EGFR therapy for TKI generations 1 and 2 have almost the same efficacy, in which there is nosignificant difference in the quality of life of the participants.

Drug Hypersensitivity in Daily Practice Gatot Soegiarto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 2 (2019)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRACTAdverse drug reactions can affect up to 25% of outpatients and 10–20% of hospitalized patients. They are an important public health issue due to the potential of fatal outcomes. They are increasingly common in daily practice, but ascertaining whether the adverse reaction is a true allergic reaction to the drug is not easy. Drug hypersensitivity encompasses a spectrum of immunologically and non-immunologically-mediated reactions with varying mechanisms and clinical presentations. Factors associated with an increased risk of developing a drug hypersensitivity include patient-related factors, treatment regimen-related factors, and drug-related factors. Diagnosis of drug hypersensitivity relies on a careful history and physical examination and, in some instances, in vivo and in vitro testing and drug provocation tests. The most effective strategy for the management of drug allergy is avoidance and discontinuation of the offending drug(s). Alternative medications with unrelated chemical structures should be given. Additional therapy is largely supportive which includes nutritional support, fluid replacement, and symptomatic which may include topical corticosteroids, oral antihistamines and, in severe cases, systemic corticosteroids. This article will discuss the classification of adverse reactions to drugs, professional steps that can be taken by a physician in prescribing drugs, minimizing the risk of adverse drug reactions, approach to diagnosis, and managing drug hypersensitivity cases in daily practice.Keywords: drug reaction, drug hypersensitivity, drug allergyCorrespondence to: gatotsby@yahoo.com ABSTRAKReaksi efek samping obat dapat mengenai sekitar 25% pasien rawat jalan dan 10-20% pasien rawat inap. Reaksi efek samping obat adalah masalah kesehatan masyarakat yang penting karena berpotensi fatal. Hal tersebut semakin umum dijumpai dalam praktek sehari-hari, tetapi memastikan apakah reaksi efek samping tersebut adalah reaksi alergi yang sebenarnya terhadap obat itu tidaklah mudah. Hipersensitivitas obat mencakup spektrum reaksi yang dimediasi secara imunologis dan non imunologis dengan berbagai mekanisme dan presentasi klinis. Faktor-faktor yang terkait dengan peningkatan risiko terjadinya hipersensitivitas obat meliputi faktor terkait pasien, faktor terkait regimen pengobatan, dan faktor terkait obat. Diagnosis hipersensitivitas obat bergantung pada anamnesis dan pemeriksaan fisik yang cermat dan, dalam beberapa kasus, tes in vivo dan in vitro dan tes provokasi obat. Strategi yang paling efektif untuk pengelolaan alergi obat adalah penghindaran dan penghentian obat-obatan tersebut. Obat-obatan alternatif dengan struktur kimia yang tidak terkait harus diberikan. Terapi terapi suportif yang mencakup dukungan nutrisi, penggantian cairan, dan gejala yang mungkin termasuk kortikosteroid topikal, antihistamin oral dan, dalam kasus yang parah, kortikosteroid sistemik dapat diberikan. Artikel ini akan membahas klasifikasi reaksi efek samping terhadap obat, langkah profesional yang dapat diambil oleh dokter dalam meresepkan obat, meminimalkan risiko reaksi efek samping obat, pendekatan untuk diagnosis, dan manajemen kasus hipersensitivitas obat dalam praktik sehari-hari.Kata kunci: Reaksi obat, hipersensitivitas obat, alergi obatKorespondensi: gatotsby@yahoo.com

The role of gut microbiota in health and diseases Deasy Fetarayani; Handoko Hariyono; Gatot Soegiarto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.5846

ABSTRACTABSTRACTMicrobiota contributes a crucial part in the human hosts' health and actively provides to the emergence of various diseases. The optimal composition of healthy intestinal microbiota varies from person to person. The more various and abundant of the microbiota, the greater their resistance to outside hazards. Colonization of the microbiota in the human body starts after delivery and develops continuously from infant to adult. The largest microbial colony is constructed in the lower part of the adult human digestive tract. The composition of the human intestinal microbiota alters promptly during the beginning of life and is steady. It has been described the close relationship among dysbiosis of the intestinal microbiota with intestinal and non-intestinal diseases. Nevertheless, it is uncertain whether dysbiosis is the culprit of the disease or only as a result of the disease. Human microbiota's role must be investigated more deeply so that later it can be developed for the prevention, diagnosis of disease, and more effective treatment strategies in the future. In this minireview, we will describe the development of the gut microbiota, its interaction with our bodily systems and defense, the multiple causes of dysbiosis, and its impact on several metabolic in inflammatory diseases in humans. With this insight, it is hoped that we can be more cautious about using antibiotics, avoid things that lead to dysbiosis, and handle diseases more holistically, putting the balance of the microbiota into account. Keywords: human, microbiota, gastrointestinal tract, dysbiosis, health and diseaseCorresponding author: deasyfetarayani@gmail.com

LYMPHOCYTE-T TYPE TH1 AND TH2 ACTIVITY DIFFERENCE OF LUNG TISSUE ON Heligmosomoides polygyrus NEMATODE AND Mycobacterium tuberculosis SEQUENTIAL CO-INFECTION Laksmi Wulandari; Muhammad Amin; Soedarto Soedarto; Gatot Soegiarto
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that are often associated with uneffectiveness of the BCG vaccine and the high worm infection. The objective of this study was to determine the differences in the activity of Limfosit T type Th1 (IFN-g) and Th2 (IL-4) in lung tissue on Heligmosomoides polygyrus nematode and Mycobacterium tuberculosis sequential co-infection. This research using 49 mice were divide into 7 groups treated with infection by Mycobacterium tuberculose inhaled and Heligmosomoides polygyrus orally within 8 and 16 weeks. The levels of IFN-g in peripheral blood serum (89.929 + 3.533 pg/mL) resembles the pattern of the percentage of lymphocytes T CD4+ Th1 in lung tissue (3.246 + 0.519%) and peripheral blood (4.950 + 0.237%), while the levels IL-4 in the peripheral blood serum (20.782 + 4.043%) resembles the pattern of the percentage of lymphocytes T CD4+ Th2 in intestinal tissue (1.048 + 0.359%) and peripheral blood (1.196 + 0.557%). In conclusion, there is difference in the activity of lymphocytes T type Th1 and Th2 but it does not affect the immune response to Mycobacterium tuberculosis infection.

CETIRIZINE SUPPRESSION TO SKIN PRICK TEST RESULTS IN ATOPIC ALLERGY PATIENTS Gatot Soegiarto; David Kurnia; Chairul Effendi; Putu Gedhe Konthen
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Faculty of Medicine, Universitas Airlangga

This study was done to determine the suppression index of Cetirizine to the skin prick test results to obtain a correction constant or factor that can be used to assess the results of the skin prick test in patients who cannot stop the use of antihistamines (Cetirizine). This pre and post test study design clinical trial involved 22 atopic allergy patients who seek medical treatment at the Allergy and Immunology Outpatient Clinic Dr. Soetomo Hospital. Skin prick tests were done twice (SPT1 and SPT2) using house dust mite allergen extract to all study subjecs. The first (SPT1) were done after washout of all antihistamine for 1 week prior the test. All study subjects were then given Cetirizine 10 mg once daily for 5 days and on day 6 we performed the second test (SPT2). Cetirizine suppresion index and correction factor were calculated by comparing the wheal area of SPT1 and SPT2. All 22 study subjects (6 males and 16 females) were sensitized to house dust mite allergen. Mean serum total IgE levels were 176.42 + 352.5 IU/dL. Mean wheal area generated by the positive control (histamine 1 mg/mL) in SPT1 was 7.53 + 7.31 mm2, and in SPT2 was 1.08 + 1.46 mm2. Mean wheal area generated by house dust mite allergen in SPT1 was 43.57 + 36 mm2, and in SPT2 was 10.28 + 8.47 mm2. Cetirizine suppression index for positive controls (histamine 10 mg/mL) was 94.63 + 7.90% (p=0.000), while the Cetirizine suppression index for house dust mite allergen is 72.31 + 13.96% (p=0.000). There was no significant influence of serum total IgE levels to Cetirizine suppression index (p=0.381). The correction constant based on the calculation was 1.9. In conclusion, Cetirizine suppression index to the mean wheals area generated by house dust mite allergen was 72.31% and the correction constant was 1.9. In allergic patients who cannot stop their antihistamine drugs, Cetirizine 10 mg once daily can be used as a replacement and they still be able to undergo skin prick tests. The actual wheal diameter (or area) of the skin prick test results can be calculated by multiplying the measured wheal diameter (or area) under the Cetirizine administration with the correction constant.

Co-Authors Aldise Mareta Aldise Mareta, Aldise Anang Endaryanto Ari Baskoro Azwin Mengindra Putera Bayu Dharma S Camilia Metadea Aji Savitri Chairul Effendi Chairul Effendi David Kurnia Deasy Fetarayani Dian Ristanti Djoko Poetranto Djoko Poetranto, Djoko Edith Frederika Edith Frederika, Edith Far-Far, Imanuel Handoko Hariyono Hermina Novida Hermina Novida, Hermina Isyroqiyyah, Nur Moya Laksmi Wulandari Lucia Landia Setyowati Lucia Landia Setyowati, Lucia Landia Luki Agustina Damayanti Masaoki Yamaoka Masaoki Yamaoka, Masaoki Muhammad Amin Mukti Fahimi Nur Moya Isyroqiyyah Putu Gedhe Konthen Reinaldi Rachmadhianto Resti Yudhawati Retno Asih Setyoningrum Ristanti, Dian Setiawati, Yuani Soedarto Soedarto Suwandi Tri Hartini Yuliawati Yuani Setiawati

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