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All Journal Paediatrica Indonesiana
Sunartini Sunartini
Department of Child Health, Universitas Gadjah Mada Medical School/Dr. Sardjito Hospital, Yogyakarta, Central Java
Health Professions Medicine & Pharmacology

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Motor clinical progression in a series of pediatric Duchenne and Becker muscular dystrophy cases Zakiah Nur Istianah; Sunartini Sunartini; Sasmito Nugroho
Paediatrica Indonesiana Vol 59 No 2 (2019): March 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2412.819 KB) | DOI: 10.14238/pi59.2.2019.51-4

Abstract

Muscular dystrophy is a neuromuscular disorder that begins with muscle weakness and impaired motor function. Duchenne muscular dystrophy (DMD) is more severe and destructive than Becker muscular dystrophy (BMD), and both are progressive in nature. These 2 types of muscular dystrophy are caused by mutations in related to X-chromosome genes.1 The mutations that occur in DMD are nonsense mutations. Deletion is present in 60% of DMD cases, while duplication occurs in 10% of DMD cases, resulting in loss of dystrophin protein. Mutations in BMD are missense mutations, so dystrophin is still formed, but in decreased amounts and quality.2,3 The prevalence of DMD was reported to be three times greater than that of BMD, with a prevalence of 1.02 per 10,000 male births vs. 0.36 per 10,000 male infants, respectiveley.4 Anatomical pathology examination revealed loss of dystrophin in the examination of muscle biopsy without the presence of evidence leading to other neuromuscular diseases. Clinical DMD symptoms begin to appear at the age of 2-4 years. The child is observed to fall often and has difficulty climbing stairs. Muscle weakness worsens, especially in the upper limbs, continuing with heart and respiratory problems. The main causes of death in DMD are respiratory failure and heart failure.5 The BMD has varied clinical symptoms, beginning with the appearance of myalgia, muscle cramps, and arm weakness progressing towards myopathy. Some patients are asymptomatic until the age of 15, but 50% of patients show symptoms at age 10, and almost all by age 20.6
Positive Tuberculin and Primary Tuberculosis Frequency among Non-BCG Children of 0-4 years (Preliminary Report) Jati Soenarto; Achmad Surjono; Djauhari Ismail; Sunartini Sunartini; Soekardi Dirdjohusodo
Paediatrica Indonesiana Vol 16 No 9-10 (1976): September - October 1976
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (730.257 KB) | DOI: 10.14238/pi16.9-10.1976.365-72

Abstract

The tuberculin test, rontgen photos, and nutritional condition of babies and pre-school children admitted to the Department of Child Health, University of Gadjah Mada Hospital, revealed: - A very high tuberculin index among the children examined, especially those under one year of age, much higher than the figures ever to be reported in Indonesia. - A direct correlation between the size of induration and the likelihood of finding pulmonary abnormalities. - A close relationship between deficient nutritional status and rontgenologic abnormalities of the lungs. We think that deficient nutritional status develops due to the presence of tuberculosis infection. Based on the factors mentioned above, in the national campaign against tuberculosis the following should be considered : - BCG at the earliest possible moment (neonatal period/life). - INH chemoprophylactic to all positive contact children will effectively prevent clinical manifestation as well as improve nutritional status.
Sleep disorders and associated factors in children with cerebral palsy Sari Wardhani Mahligai Patery; Sunartini Sunartini; Retno Sutomo
Paediatrica Indonesiana Vol 61 No 4 (2021): July 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.4.2021.179-85

Abstract

Background Sleep disorders are a condition affecting quality and quantity of sleep. Children with cerebral palsy (CP) have higher risk of sleep disorders than those with no chronic disease. Objective To determine the prevalence and factors associated with sleep disorders in children with CP. Methods We conducted an analytic, observational study with cross-sectional design in children aged 4-10 years with CP. Subjects were recruited consecutively; children with chronic diseases (cardiovascular, malignancy, chronic obstructive pulmonary disease, and diabetes mellitus) were excluded from the study. Primary data including sociodemographics, intensity of physiotherapy outside Sardjito General Hospital (SGH), sleep hygiene, and sleep disorders were collected from the Children’s Sleep Habit Questionnaire (CSHQ). Secondary data were acquired from medical records, such as type of CP, severity of motor function impairment, presence of epilepsy, intensity of physiotherapy performed at SGH, as well as anti-epileptic, anti-spastic, and sleep-affecting medicines. Results We found sleep disorders in 64 of 75 (85%) subjects, mostly bedtime resistance (66%). Spastic quadriplegia (OR=3.63; 95%CI 1.82 to15.94) and presence of epilepsy (OR=7.82; 95%CI 1.53 to 39.84) were significantly associated with sleep disorders in children with CP aged 4-10 years. Conclusion Sleep disorders are common in children with CP, with the majority experiencing bedtime resistance. Sleep disorders are more prevalent in subjects with spastic quadriplegia and epilepsy.
Co-Authors Achmad Surjono Djauhari Ismail Jati Soenarto Retno Sutomo Sari Wardhani Mahligai Patery Sasmito Nugroho Soekardi Dirdjohusodo Zakiah Nur Istianah