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Najib Advani

Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta

Author-ID : 3472995

Health Professions Medicine & Pharmacology

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Articles

Predictors for coronary artery dilatation in Kawasaki disease Najib Advani; Anisa Rahmadhany; Sarah Rafika
Paediatrica Indonesiana Vol 58 No 5 (2018): September 2018
Publisher : Indonesian Pediatric Society

Background Kawasaki disease (KD) is an acute, self-limited, febrile illness of unknown cause that predominantly affects children below 5 years of age. It has a high incidence of coronary complications such as aneurysms. The current treatment of choice is intravenous immunoglobulin, which is costly, with aspirin. Identifying the predictive factors for coronary artery dilatation or aneurysm is important in order to establish the indications for giving immunoglobulin, especially when resources are limited. Objective To identify the predictors for the development of coronary artery dilatation in patients with Kawasaki disease Methods This cross-sectional study was done between January 2003 and July 2013. Inclusion criteria were patients who fulfilled the American Heart Association criteria for acute Kawasaki disease, and had complete clinical, echocardiogram, and laboratory data [hemoglobin, leukocyte, platelet, albumin, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR)]. All of them received immunoglobulin and aspirin. Results Of 667 KD patients, 275 met the inclusion criteria. There were 185 (67%) males. Subjectsâ€™ ages varied between 1 to 157 months. The frequency of coronary artery dilatation at the acute phase was 33.3%. Multivariate analysis showed that >7-day duration of fever and hypoalbuminemia were significant predictive factors for coronary artery dilatation. Conclusion Predictive factors for coronary artery dilatation are duration of fever over 7 days and hypoalbuminemia, while age, gender, hemoglobin level, leukocyte count, and platelet count are not. Frequency of coronary artery dilatation at the acute phase is 33.3%.

A Case of Rett Syndrome Samuel Lazuardi; Najib Advani; Sofyan Ismael
Paediatrica Indonesiana Vol 29 No 11-12 (1989): November - December 1989
Publisher : Indonesian Pediatric Society

A case of Rett syndrome in a-3 Â½ year-old girl is presented. The patient had normal pre and perinatal period and normal psychomotor development till the age of 14 months, followed by behavioural, social and psychomotor regression. Physical examination revealed a below normal head circumference, loss of eye and psychic contact, stereotypic hand movements and gait disturbance. No laboratory test can confirm the diagnosis of Rett syndrome, therefore the diagnosis was established by virtue of history of illness and clinical manifestations. This is the first case of Rett syndrome found and reported in Indonesia.

Diagnosis of Rheumatic Fever: Which Modification? Bambang Madiyono; Sudigdo Sastroasmoro; Ismet N. Oesman; Sukman Tulus Putra; Najib Advani
Paediatrica Indonesiana Vol 34 No 5-6 (1994): May - June 1994
Publisher : Indonesian Pediatric Society

We evaluated the implementation of diagnostic criteria on 547 ambulatory patients with rheumatic fever (RF) and rheumatic heart disease (RHD) between January 1, 1983 and December 31, 1992. The diagnosis of RF and reactive RHD was established by either revised Jones criteria, modified Jones criteria, or clinical judgment The patient's age ranged from 4-18 years, 255 (46.6%) of them were boys. The clinical manifestations found were fever (58.1 %), arthritis (41.9%), chorea (8.6%), subcutaneous nodule (1.3%), erythema marginatum (1.1%), holosystolic murmur (56.9%), mid-diastolic murmur (25.4%), and early diastolic murmur (29.5%). The laboratory changes were hemoglobin <10 g/dl (16.5%), BSR > 20 mm/h (56.30/o), ASTO >200 U (29.6%), PR interval> 0.16 sec (13.3%), and erR> 0.55 (27.6%). Revised Jones criteria were met in 162 cases (29%), modified criteria in 474 cases (86,6%), and clinical judgment in 521 cases (95.2%).

Hereditary Long Q-T Without Congenital Deafness (Romano-Ward) Syndrome Bambang Madiyono; Alinda Rubiati Wibowo; Ismet N. Oesman; Sudigdo Sastroasmoro; Sukman Tulus Putra; Najib Advani
Paediatrica Indonesiana Vol 34 No 7-8 (1994): July - August 1994
Publisher : Indonesian Pediatric Society

We report a case o fhereditary long Q-T syndrome without congenital deafness (Romano-Ward syndrome). In four members of a family, a father and his daughters, the Q-T intervals on the EKG were found to be prolonged. There were no other accompanying familial anomalies such as deafness or a tendency to extracellular hypokalemia The youngest daughter which had the longest. Q-T interval had several Adams-Stokes attacks, and died in the last attack at the age of 23 months. Her two older siblings died at the age of 15 and 10 months with the same typical clinical histories. The eldest daughter, a 12-year old girl, has no clinical symptoms at all, while the fourth child, 5-yeltr old girl has several occasions of near fainting attacks. The EKG of the father showed several runs of supraventricular premature contractions that ceased spontaneously, besides evidence of the prolongation of Q-T interval. The beta-adrenergic blocking drug (propranalol) given in a relatively small maintenance dose, proved to be effective in preventing attacks of the father and the fourth child, despite the unchanged prolongation of the Q-T interval.

Effects of lung recruitment maneuvers using mechanical ventilator on preterm hemodynamics Adhi Teguh Perma Iskandar; Ahmad Kautsar; Anisa Rahmadhany; Risma Kerina Kaban; Bambang Supriyatno; Joedo Prihartono; Dewi I. Santoso; Tetty Yuniarti; Najib Advani; Mulyadi M. Djer; Fiolita I. Sutjipto
Paediatrica Indonesiana Vol 63 No 3 (2023): May 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.3.2023.173-80

Background Lung recruitment maneuvers (LRMs) are a strategy to gradually increase mean positive airway pressure (MAP) to expand the alveoli, leading to decreased pulmonary vascular resistance and increased cardiac output (CO). However, the hemodynamic impact of LRM using assist control volume guarantee (AC-VG) ventilator mode done in preterm infants born at 24 to 32 weeksâ€™ gestation, especially in the first 72 hours of life, remains unknown. Objective To determine the effect of LRM on right- and left cardiac ventricular output (RVO and LVO), ductus arteriosus (DA) diameter and its pulmonary hypertension (PH) flow pattern, as well as superior mesenteric artery (SMA) flow. Method This randomized, controlled, single-blinded clinical trial was performed in 24-32-week preterm neonates with birth weights of >600 grams. Subjects were allocated by block randomization to the LRM and control groups, each containing 55 subjects. We measured RVO, LVO, DA diameter, PH flow pattern, and SMA resistive index (RI) at 1 and 72 hours after mechanical ventilation was applied. We analyzed for hemodynamic differences between the two groups. Results During the initial 72 hours of mechanical ventilation, there were no significant differences between the control vs. LRM groups in mean changes of LVO [41.40 (SD 91.21) vs. 15.65 (SD 82.39) mL/kg/min, respectively; (P=0.138)] or mean changes of RVO [65.56 (SD 151.20) vs. 70.59 (SD 133.95) mL/kg/min, respectively; (P=0.859)]. Median DA diameter reduction was -0.08 [interquartile range (IQR) -0.55; 0.14] mm in the control group and -0.10 (IQR -0.17 to -0.01) mm in the LRM group (P=0.481). Median SMA resistive index was 0.02 (IQR -0.16 to 0.24) vs. 0.01(IQR -0.20 to 0.10) in the control vs. LRM group, respectively. There was no difference in proportion of pulmonary hypertension flow pattern at 72 hours (25.4% vs. 20% in the control vs. LRM group, respectively) (P=0.495). Conclusion When preterm infants of 24-32 weeks gestational age are placed on mechanical ventilation, LRM gives neither additional hemodynamic benefit nor harm compared to standard ventilator settings.

Co-Authors Adhi Teguh Perma Iskandar Ahmad Kautsar Alinda Rubiati Wibowo Anisa Rahmadhany Bambang Madiyono Bambang Supriyatno Dewi I. Santoso Fiolita I. Sutjipto Ismet N. Oesman Joedo Prihartono Mulyadi M. Djer Risma Kerina Kaban Samuel Lazuardi Sarah Rafika Sofyan Ismael Sudigdo Sastroasmoro Sudigdo Sastroasmoro Sukman Tulus Putra Sukman Tulus Putra Tetty Yuniarti

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