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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Ilmiah Kesehatan (JIKA)
Irfiansyah Irwadi
Airlangga University
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Biomolecular and Health Science Journal

 1 
The Effect of Sapodilla Leaves (Achras Zapota) Infusum towards Mice (Mus Muculus) Diarrheal Activity Induced by Oleum Ricini Glabela Christiana Pandango; Ramadhani R. B; Irfiansyah Irwadi
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.537 KB) | DOI: 10.20473/bhsj.v1i1.8194

Abstract

Introduction: Diarrhea is a significant health problem, especially in countries with low income. In many cases, diarrhea even can cause death. Treatment for diarrhea has been done both pharmacologically (including the usage of herbal remedies) and non-pharmacologically. Decoction of the sapodilla’s leaves is often used to treat diarrhea, but no studies directly demonstrates the effects of sapodilla’s leaves’ decoction towards living creatures. The purpose of this study was to determine the effect of sapodilla leaves’ (Achras zapota) infusum towards diarrheal activity of mice (Mus musculus) which can be seen through the onset and frequency of diarrhea, and the consistency and quantity / weight of feces.Methods: 30 mice were divided into five groups. Negative controls (group I) were administered with oleum Ricini, positive controls (group II) were administered with oleum Ricini and Loperamide HCl after half-an hour, and group III, IV, and V, were administered with oleum Ricini and sapodilla leaves’ (Achras zapota) infusum ( with the concentration of 5 g %, 10 g %, and 20 g %) after half-an hour. Then, those mice were observed for 3 hours for their diarrheal activity (diarrheal onset, frequency, fecal consistency, and fecal weights).Results: Analysis by Kruskal-Wallis method showed significant differences of diarrheal activities among the five groups (p = 0.023). Whilst, analysis by Mann-Whitney method showed significant differences between group I and II (p = 0.04), group I and III (p = 0.012), and group I and IV (p = 0.006).Conclusions: Based on the result showed sapodilla leaves’ (Achras zapota) infusum could reduce diarrheal activity of mice (Mus musculus).
Co-Authors Ahmad Suryawan Bambang Purwanto Damayanti Damayanti Diah Mira Indramaya Eka Arum Cahyaning Putri Glabela Christiana Pandango Hayuris Kinandita Setiawan Laili Nur Rosyidah Menul Ayu Umborowati Misbakhul Munir Paulus Parholong Siahaan Purwo Sri Rejeki Raden Mohammad Budiarto Rahmadewi Rahmadewi Ramadhani R. B Septyaningrum Putri Purwoto Soffil Yudha Mulyadi Tasya Wikassa Trisniartami Setyaningrum