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All Journal Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Sasambo Journal of Pharmacy
Erwin Prasetya Toepak
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology

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Profil fitokimia dan aktivitas antibakteri fraksi etil asetat akar jarak pagar (Jatropha curcas Linn.) Sudarman Rahman; Stevin Carolius Angga; Erwin Prasetya Toepak; Muhammad Takdir Bachtiar
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.8 KB) | DOI: 10.29303/sjp.v2i2.116

Abstract

Bacterial infections are a major cause of chronic infections and mortality that continues to threaten public health worldwide. Various medicinal plants used in folk medicine have demonstrated wound healing and antibacterial properties. The aims of the study are investigation phytochemical and antibacterial activity of ethyl acetate fraction from jarak pagar roots (Jatropha curcas Linn.). The roots were treated with maceration method using ethanol 70% and subsequently fractioned to ethyl acetate fraction. The fractions were used for phytochemical screening and antibacterial assay using Kirby and Bauer agar difussion method. The results showed that ethyl acetate fraction jarak pagar roots contained alkaloid, flavonoids, saponins, steroids, poliphenol dan tannins. The antibacterial activity of jarak pagar roots againts Staphylococcus aureus and Escherichia coli shows that the activity of this fraction with concentration 8 mg/mL has strong inhibitory potency against the growth S. aureus with inhibitory zone is 14,3 mm and has moderate inhibitory potency against E. coli with inhibitory zone is 9 mm. The increase concentrations of ethyl asetate fraction jarak pagar roots shows high inhibition diameter of bacterial growth.  
SKRINING FITOKIMIA DAN UJI ANTIOKSIDAN MENGGUNAKAN METODE DPPH PADA EKSTRAK METANOL BUAH TERUNG ASAM BESAR (Solanum Ferox Linn) Lilis Rosmainar; Erwin Prasetya Toepak; Wahyu Nugroho
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 5 No. 1 (2023): Penelitian Kimia dan terapannya 2023
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v5i1.2590

Abstract

Penelitian ini bertujuan untuk skrining fitokimia dan uji antioksidan menggunakan metode DPPH pada ekstrak metanol buah terung asam besar (Solanum Ferox Linn). Yang diamati dalam penelitian ini adalah meneliti kandungan senyawa metabolit sekunder yang terdapat pada buah terung asam dengan menggunakan ekstrak metanol dan uji aktivasi antioksidan menggunakan metode DPPH. Ekstrak metanol pada terung asam besar teridentifikasi mengandung senyawa golongan alkaloid,terpenoid ,flavonoid, dan fenolat. Hasil uji aktivitas antioksidan ekstrak menunjukkan bahwa ekstrak metanol memiliki aktivitas antioksidan dengan nilai IC50 yakni 314,084 ppm. Hasil uji aktivitas antioksidan ekstrak menunjukkan bahwa vitamin C memiliki aktivitas antioksidan dengan nilai IC50 yakni 5,49 ppm. Terung asam besar mempunyai nilai IC50 314,084 µg/mL yang menunjukan bahwa terung asam memiliki aktivitas antioksidan yang lemah. Sebagai kontrol positif digunakan vitamin C karena vitamin ini merupakan antioksidan sekunder alami yang memiliki aktivitas antioksidan sangat kuat yang terlihat dari nilai IC50 sebesar 5,49 µg/mL.
Aktivitas antioksidan dan uji sitotoksik infusa daun jarak pagar (Jatropha curcas) Sudarman Rahman; Alayya Adistia Putri; Erwin Prasetya Toepak; Stevin Carolius Angga; Ysrafil Ysrafil
Sasambo Journal of Pharmacy Vol. 4 No. 2 (2023): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i2.232

Abstract

Antioxidants are crucial in preventing cell damage caused by oxidation from oxidants. The use of antioxidants from natural products such as Jatropha curcas leaves can counteract free radicals due to the presence of secondary metabolites. The main aims of the study were to determine the antioxidant and cytotoxic activity of the infusion of J. curcas leaves. The sample was extracted using the infusion method. A qualitative phytochemical screening was carried out using the test tube method, antioxidant assay using the DPPH method and cytotoxic using the BSLT method. The results showed that the infuse of J. curcas leaves contained secondary metabolites such as polyphenols and tannins, alkaloids, flavonoids, and saponins. In the antioxidant activity test, infuse of J. curcas leaves and vitamin C (control) the IC50 was 58.90±2.34 ppm and 8.78±0.21 ppm respectively. The infused cytotoxic test contained an active toxic compound in shrimp larvae with an LC50 of 200.28 ppm (LC50 ≤ 1000 ppm). Based on the results of the study, infuse of J. curcas leaves showed potential as an antioxidant and anticancer agent with a strong classification.
Co-Authors Alayya Adistia Putri Lilis Rosmainar Muhammad Takdir Bachtiar Rahman, Sudarman Stevin Carolius Angga Wahyu Nugroho Ysrafil Ysrafil