Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
P B Notopoero
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
ERITROPOITIN FISIOLOGI, ASPEK KLINIK, DAN LABORATORIK P B Notopoero
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.922

Abstract

Erythropoietin is a glycoprotein hormone produced by kidney and functioning as regulator for eryhtropoietic processes. The regulation of erythropoietic processes are stimulation of proliferation, maturation erythroid progenitor cells and prevention of apoptotic process.The balance between dinamic erythropoietic processes and loss of erythrocytes is regulated by homeostatic mechanism. The decrementof EPO production will cause anemia such as anemia in end state renal disease. The development of rHuEPO support the invention ofsensitive and specific immunoassay methods to measure the level of EPO. There are various commercial kit using various immunoassaymethods used to achieve this purpose. The use of rHuEPO gives dramatic impact for the improvement of end state renal disease patients’squality of life. The research for the effect of EPO in the neuron, vascular, and retinous tissue develop the use of EPO for the neurology,cardiology and opthalmology area. This should be followed with the understanding of the patophysiology of EPO effect in the variousorgans. In 1990. the rHuEPO is used to replace the blood transfusion as the blood doping. The various direct and indirect methods candetect the missuse of rHuEPO as doping in the world sport events.
PERBANDINGAN SEDIAAN BASAH DENGAN SEDIAAN GRAM HAPUSAN SEKRET VAGINA UNTUK DIAGNOSIS BACTERIAL VAGINOSIS P B Notopoero; Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.888

Abstract

Bacterial vaginosis (BV) is a clinical condition with changes in the vaginal ecosystem. Under normal conditions, the vaginalecosystem contains Lactobacilli microflora but in BV condition, it contains mixed microflora ie combination of anaerobic bacteria andGardnerella sp. There are approximately 300 cases of BV a year in the Dr. Soetomo General Hospital. We can examine vaginal fluidmicroscopically to diagnose BV with wet mount and Gram stain method. Wet mount method is fast to do that clinicians can establishthe diagnosis and therapy earlier. Gram stain method is the gold standard method and more common to do in the laboratory but thestaining method can affect the result. This study aims to know the diagnostic value of wet mount method compared with Gram stainmethod for BV. There were 30 subjects from the Gynaecology Outpatient Clinic in the Dr. Soetomo General Hospital. They presentedwith from the leucorrhoea and fullfiled the clinical criteria for BV. We took the vaginal fluid and examined them with wet mount andGram stain microscopy. The percentage of agreement between wet mount and Gram stain method for BV Grade I is 66%, BV grade IIis 66%, BV grade III is 84.6%, and BV grade IV is 100%. The sensitivity of wet mount method is 85.71%, the specificity is 88.88%, thepositive predictive value and negative predictive value are 94.73% and 72.72%. Based on these data, wet mount method can replaceGram stain method to diagnose BV microscopically in the case that there is not enough time and resource for Gram stain. The wet mountmethod has good sensitivity, specificity, positive and negative predictive value. Wet mount method has a shortcoming in identifying themicroorganism, but this problem can be solved by combining this method with Gram stain method.
Co-Authors Prihatini Prihatini