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All Journal Jurnal MIPA Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Julianri Sari Lebang
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics

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Studies of Wound Healing Activity and Irritation Test of Chili (Capsicum frutescens L.) Leaves Gel on Rats (Rattus novergicus): (Studi Aktivitas Penyembuhan Luka Dan Uji Iritasi Gel Daun Cabai Rawit (Capsicum frutescens L.) Pada Tikus (Rattus novergicus) Julianri Sari Lebang; Jainer Pasca Siampa; Nurmiati Nurmiati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15430

Abstract

Chili pepper (Capsicum frutescens L.) leaves have been used empirically as wound healing caused by sharp objects. Several studies showed that it has antibacterial and wound healing activities. This study aims to formulate gel from chili leaves extract, then determine wound healing activity and irritating properties on rat’s skin. Gel was formulated by using various types and concentrations of gelling agents, consisted of Carbopol 0.5%, 0.75%, 1% and hydroxy propyl methyl cellulose at 2.5%, 5% and 7.5% respectively. Cycling test was conducted to determine the physical stabilities. The results showed that all formula has no altered on organoleptic properties and pH value. Gel of 0.5% Carbopol (F2) and 7.5% of HMPC (F5) has no change in spreadability and adhesion properties. Based on statistical analysis using paired t-test and one-way ANOVA, it concludes that F2 and F5 were physically stable and further evaluated as wound healer. Wound healer evaluation showed that the healing time (days) of Carbopol based gel (F2) was 10.2±1.26 and HPMC based gel was 8±0.82. The length of incision wound (cm) at 8th day was 0.5±0.183 for F2 and 0.06±0.071 for F5. Statistical analysis of healing time showed p<0.01 and wound length showed p<0.05 indicated that F5 (contained 5% HPMC) was significantly different compared to negative control. The results of the irritation test showed that gel formulas were not causing erythema and edema on rat’s skin. It can be concluded that gel of chili leaves extract that formulated with 5% of HPMC has wound healing activity and safety to be used.
Efek Pemberian Ekstrak Buah Salak (Salacca zalacca) dalam menurunkan kadar glukosa darah pada tikus model Diabetes melitus Olvie Syenni Datu; Julianri Sari Lebang; Elly Juliana Suoth
Jurnal MIPA Vol. 12 No. 1 (2023)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v12i1.44267

Abstract

Diabetes Mellitus is a chronic disease characterized by elevated blood glucose levels. Diabetes Mellitus is a global disease that affects 536.6 million people in the world and is predicted to increase to 643 million people in 2030 and 783.2 million people in 2045. Snake fruit is one of the fruits in North Sulawesi that has the potential to be developed. be an alternative to treatment. The aims of this study is was to examine the effect of snake fruit extract in rats with diabetes mellitus model. The study used 5 groups, negative control group was given NaCMC solution, the positive control group was given metformin and the treatment group was given snake fruit extract with concentrations of 10%, 20% and 40%. The parameters observed in this study were body weight and blood glucose profile. The study showed that the administration of snake fruit extract had a significant effect on blood glucose profiles and body weight with p < 0.05 and there were significant differences between each treatment group both in the glucose profile parameters and body weight of rats.
Co-Authors Datu, Olvie Syenni Elly Juliana Suoth Jainer Pasca Siampa Nurmiati Nurmiati