Article Per Year (5 Year)
p-Index From 2019 - 2024
0.983
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Health and Medical Journal Unri Conference Series: Community Engagement
Huriatul Masdar
Universitas Riau
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Mangrove (Rhizophora sp.) Fruit Extract Inhibits Tumor Growth Factor (TGF)-β1 Expression in High Cholesterol Diet-Fed Rats: Ekstrak Buah Bakau (Rhizophora sp.) Menghambat Ekspresi Tumor Growth Factor(TGF)-β1 pada Tikus yang Mendapat Diet Tinggi Kolesterol Muhammad Yulis Hamidy; Huriatul Masdar; Winarto Winarto
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 3 (2021): (December 2021
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i3.15667

Abstract

Background: Atherosclerosis is a major finding in cardiovascular disease. One of the pro-fibrotic cytokines that play an important role in the atherosclerosis process is Tumor Growth Factor (TGF)-β1, where the presence of high TGF-β1 secretion due to hypercholesterolemia will trigger excessive collagen matrix formation. Objective: To analyze Rhizophora sp fruit extract effect on TGF-β1 expression in high cholesterol diet-fed rats. Material and Methods: Eighteen 10-week-old rats weighing 150-200 g were used in this study. These animals were grouped into 3 groups, each consisting of 6 rats. Group A (normal control) is a group of rats that received a normal diet. Group B (atherogenic control) received a diet that induces atherosclerosis (atherogenic diet). This diet contains 2% cholesterol, 5% goat fat, 0.2% cholic acid and standard diet up to 100%. Atherogenic diet was given for 3 days, and on the first day this group also received vitamin D3 700,000 IU/kg. Group C (treated), apart from receiving an atherogenic diet, was also given Rhizophora sp fruit extract 500 mg/kg body weight. The Rhizophora sp fruit extract effect on TGF-β1 expression was evaluated by immunohistochemical procedure. The area of ​​the expression is calculated using the ImageJ. Results: The results of this study indicate that the expression of TGF-β1 is higher in the group receiving the atherogenic diet than the normal control group (17.3 vs. 8.9; P=0.000). Rhizophora sp fruit extract reduced this expression remarkably (17.3 vs. 11.4; P=0.001). Conclusion: Rhizophora sp fruit extract inhibits the the expression of TGF-β1 in high cholesterol diet-fed rats.
Pemberdayaan masyarakat melalui pengolahan sampah anorganik menjadi barang dekoratif bernilai ekonomis Huriatul Masdar; Muhammad Yulis Hamidy; Fifia Chandra; RM Riadi; Yulia Irvani Dewi; Nurfi Pratiwi
Unri Conference Series: Community Engagement Vol 2 (2020): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.2.222-227

Abstract

Garbage is the leftover product from every human daily activity that is thrown away which, if not managed properly, can cause environmental and health problems. Waste bank is a form community participation in waste management. Air Putih Sub-dsitrict already has a waste bank that is actively operating. However its activities are still limited to collect inorganic waste from customers and sell it to collectors. In order to increase the value of inorganic waste collected in the waste bank, a training to decorate used items using decoupage technique was conducted. Waste bank managers and Empowerment Family Welfare (PKK) members were participated in this training. In addition, a training how to use social media as a marketing media were performed. The results showed that the target community's skills had been achieved in processing inorganic waste into decorative items with higher economic value. Meanwhile, the sustainability of production and the economic impact resulting from these trainings still require further evaluation.
Hubungan Onset Keluhan Nyeri Perut dan Jumlah Leukosit dengan Tingkat Keparahan Apendisitis Akut pada Anak Wahyu Jati Wibowo; Tubagus Odih Rhomdani Wahid; Huriatul Masdar
Health and Medical Journal Vol 2, No 2 (2020): HEME July 2020
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.396 KB) | DOI: 10.33854/heme.v2i2.454

Abstract

Latar belakang: Apendisitis akut selalu memerlukan terapi pembedahan. Jika apendektomi tidak dilakukan segera, akan menyebabkan perforasi pada apendiks dan kontaminasi peritoneal. Angka kejadian tertinggi apendisitis adalah pada akhir usia remaja, dengan 5% kejadian pada anak usia dibawah 5 tahun.Tujuan: Mengetahui hubungan antara onset keluhan nyeri perut dengan tingkat keparahan apendisitis akut anak serta mengetahui perbedaan rerata  jumlah leukosit apendisitis akut anak antara apendisitis non komplikata dan apendisitis komplikata. Metode: Penelitian ini merupakan penelitian analitik komparatif dan analitik korelatif dengan pendekatan retrospective. Terdapat sebanyak 68 rekam medis pasien apendisitis akut anak di RSUD Arifin Achmad Provinsi Riau periode Januari 2018 – Desember 2019. Hasil: Penelitian ini didapatkan perbandingan yang sama antara laki-laki dan perempuan, dengan didominasi pada rentang usia 6-12 tahun. Lama onset keluhan nyeri perut didominasi pada lama keluhan lebih dari 48 jam. Terdapat 69,1% apendisitis komplikata. Leukositosis terjadi pada 76,5% pasien. Hasil uji komparatif t tidak berpasangan didapatkan p=0,000, terdapat perbedaan rerata jumlah leukosit yang bermakna antara apendisitis non komplikata dan apendisitis komplikata. Nilai IK95%=4.015,7-6.683,13. Hasil uji korelasi Somers’d antara onset keluhan nyeri perut dengan keparahan apendisitis akut anak didapatkan p=0,00. Kesimpulan: Terdapat perbedaan rerata leukosit yang bermakna antara apendisitis non komplikata dan apendisitis komplikata serta terdapat hubungan yang bermakna antara onset keluhan nyeri perut dengan tingkat keparahan apendisitis akut anak dengan kekuatan hubungan kuat.
Tes Toleransi Glukosa Oral (TTGO) Pasca Pemberian Suspensi Kedelai Dibanding Suspensi Tempe pada Tikus (Rattus norvegicus Galur Wistar) Diabetik Huriatul Masdar; Muhammad Radhiatul Hakiki; Muhammad Rafi Syahputra; Tommy Satriasumatri; Deskafiani Putri; Rizki Bunaya; Desby Juananda
Health and Medical Journal Vol 3, No 2 (2021): HEME July 2021
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.225 KB) | DOI: 10.33854/heme.v3i2.634

Abstract

Introduction: Genistein, daidzein and glicytein are soybean’s isoflavones which have been known having anti diabetic effect. Fermentation process of soybean can lead to formation aglycan isoflavones which have higher bioavailability than unfermented-soybean. Aims: This research was aimed to evaluate the effect of soybean and tempeh (fermented-soybean) administration to oral glucose tolerance test (OGTT) in diabetic rats. Method: Twenty male Rattus norvegicus Wistar strains were used in this experiment, divided into 4 groups: standard, negative control, soybean and tempeh group. Type 2 diabetes in rats was induced by giving streptozotocin (50 mg/kgBW) and nicotinamide (110 mg/kgBW) intraperitoneally. Blood glucose were measured by using blood glucose test meter and classified into diabetes if its level above 200 mg/dL. Soybean (200 mg/kgBW/day) and tempeh (200 mg/kgBW/day) suspension were given by using gastric tube for 30 days. Results: The results showed the means of either fasting blood glucose (FBG) or 2 hours post prandial blood glucose (2hPP) of negative control were persistent above 200 mg/dL on day 15th and 30th  (p> 0,05). In soybean group there was a decrease the mean of FBG on day 15th  (p<0.05) but did not reach the normal level, and on day 30th the mean of FBG was <200 mg/dL (p<0.05) however 2hPP blood glucose was still >200 mg/dL (p<0.05). Furthermore, in tempeh group, the means of either FBG or 2hPP blood glucose reached the normal level in day 15th and 30th (p <0.05). Conclusion: the provision of tempeh was better in controlling blood sugar levels than soybean.
Pengaruh Ekstrak Buah Bakau (Rhizophora sp) terhadap Ekspresi Monocyte Chemoattractant Protein-1 pada Aorta Tikus Aterosklerosis Muhammad Yulis Hamidy; Huriatul Masdar; Ayu Trisya Arti
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.41-45

Abstract

Atherosclerosis is an atheromatous plaque that protrudes into and clogs blood vessels. This study aimed to analyze the effect of Rhizophora sp extract on the expression of Monocyte Chemoattractant Protein-1 (MCP-1) in the early stages of atherosclerosis in rats fed an atherogenic diet. Eighteen abdominal aortic paraffin blocks of white rats were used, consisting of 3 groups: normal diet (K1), atherogenic diet (K2), and atherogenic diet and Rhizophora sp extract (K3). The effect of Rhizophora sp extract was assessed by immunohistochemical examination. MCP-1 expression was calculated in 5 fields of view, then analyzed using Photoshop Image Analysis. The results of this study indicated that administration of Rhizophora sp extract reduced MCP-1 expression in K3 compared to K2 (0.155±0.075 vs 0.246±0.097) although this result was not statistically significant. In conclusion, Rhizophora sp extract has the ability to inhibit MCP-1 expression in the aorta of rats fed an atherogenic diet.
Co-Authors Ayu Trisya Arti Desby Juananda Deskafiani Putri Fifia Chandra Muhammad Radhiatul Hakiki Muhammad Rafi Syahputra Muhammad Yulis Hamidy Nurfi Pratiwi R Wahid, Tubagus Odih Rizki Bunaya RM Riadi Tommy Satriasumatri Wahyu Jati Wibowo Winarto Winarto Yulia Irvani Dewi