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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Danny Luhulima
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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EOSINOPENIA DAN PROCALCITONIN DALAM SEPSIS Danny Luhulima; W. Hidayati; IGAAP. Sri Rejeki; R. Permatasari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1067

Abstract

Sepsis is one of the common causes of morbidity and mortality in the ICU. Clinicians need to know and realize of good diagnosticmarkers to identify sepsis as early as possible. The role of eosinopenia as a marker of sepsis has recently been evaluated.The aim of thisstudy was to test the value of eosinopenia as a diagnostic marker of sepsis in comparison to Procalcitonin. A cross sectional study wasperformed in 61 adult patients with SIRS, and blood of all patients were cultured. Further examinations were done for comparing theeosinophil count with the Procalcitonin levels if the blood culture was positive or when there were clinical signs which supported for sepsis.In this study there were fourty two patients enrolled. Procalcitonin level yielded a sensitivity of 90.0%, specificity of 83.3%, a positivepredictive value (PPV) of 93.1% and a negative predictive value (NPV) of 76.9% at cut-off value of 2.75 ng/mL. The eosinophil (cut off ≤50 cells/μL) produced a sensitivity of 80.0%, specificity of 75.0%, PPV of 88.9%, and NPV of 60.0%. based on this study Procalcitoninappeared to be a more accurate diagnostic of sepsis than eosinopenia, but eosinopenia is still a helpful tool for clinicians, and may also beused as a diagnostic marker of sepsis, because it is highly sensitive, moderately specific, easy to measure, rapid and inexpensive as well.
NEUTROPHIL-LYMPHOCYTE COUNT RATIO IN BACTERIAL SEPSIS Danny Luhulima; Marwito Marwito; Eva O
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1204

Abstract

Sepsis akibat infeksi bakteri merupakan masalah kegawatdaruratan medik yang serius sehingga memerlukan penanganan cepat dantepat. Saat ini C-RP (C- reactive protein) dan PCT (procalcitonin) sering digunakan sebagai petanda sepsis bakterial. Sepsis adalah infeksiyang disertai inflamasi sistemik. Respons fisiologis terhadap inflamasi sistemik adalah peningkatan jumlah neutrofil dan penurunanjumlah limfosit, sehingga gabungan perbandingan neutrofil dan limfosit Neutrophil Lymphocyte Count Ratio (NLCR)) dapat digunakansebagai petanda sepsis. Penelitian ini bertujuan untuk mengetahui kepekaan dan kekhasana dari uji NLCR di pasien sepsis akibatinfeksi bakteri. Terdapat 70 pasien SIRS dengan rentang usia 14–70 tahun di RS Mitra Keluarga Bekasi Timur dan RS FK - UKI Jakartamasa waktu bulan Juli–September 2015. Penelitian ini merupakan studi observasional komparatif dan potong lintang. Hasil penelitianmenunjukkan uji NLCR terhadap sepsis bakterial berdasarkan kurva ROC memiliki kepekaan 97,8% dan kekhasan 84,0% pada cutoff ≥6,4 (AUC: 0,94, nilai p<0,05). Neutrophil lymphocyte count ratio dapat diandalkan sebagai petanda sepsis bakterial dengan ujikepekaan dan kekhasan yang baik.
Co-Authors Eva O IGAAP. Sri Rejeki Marwito Marwito R. Permatasari W. Hidayati