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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Yuyun Widaningsih
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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KADAR INTERLEUKIN-8 KANKER PAYUDARA Juranah Juranah; Yuyun Widaningsih; William Hamdani; Ruland DN Pakasi; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.471

Abstract

Metastasis is the major cause of increased morbidity and mortality in breast cancer. Interleukin-8 has a contribution in the spread of the tumour cells. This study was aimed to know IL-8 levels in patients with metastasic and non metasatic breast cancer by analyzing. A cross sectional study was performed at the Dr. Wahidin Sudirohusodo, Ibnu Sina and Labuang Baji hospitals during September to December 2011. Laboratory examinations were done in the Research Centre of the Medical Faculty, University of Hasanuddin. Fiftysix (56) subjects with breast cancer were examined. The results showed that the levels of IL-8 in metastatic and non metastatic breast cancer were 13.73 pg/mL and 10.48 pg/mL respectively. Mann-Whitney test showed no significant difference of IL-8 level between them, (p=0.09). When the subjects were divided into early and advance stages, the mean levels of IL-8 were 8.035 pg/mL and 12.052 pg/mL, respectively, showing a significant difference by Mann-Whitney test (p=0.009). Based on this research, the level of IL-8 can be considered as a marker in predicting the prognosis of breast cancer. A further research in cohort studies which specific metastasis crawl method is advised by the researchers, these are suggested to allow the determination of the risk factors.
Pengaruh Radioterapi Terhadap Parameter Hasil Pemeriksaan Darah Lengkap Pasien Karsinoma Nasofaring di Rumah Sakit Pendidikan Universitas Hasanuddin Periode 2016-2018 imam hermansyah; Eddy Zulfikar; Aton Prasetya Sibala'; William Chandra Papendang; Ahmad Fachry Toaha; Yuyun Widaningsih
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.361

Abstract

ABSTRACT Itroduction: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck areas. Recently, radiotherapy remain to be the treatment of choice for NPC, especially for the loco-regional type that hasn’t extend into distant metastasis. However, radiotherapy may cause side effect on the hematopoietic system, which has made complete blood tests mandatory for NPC patient that undergo radiotherapy treatment. Unfortunately, data regarding the effect of radiotherapy on complete blood test parameter of NPC patients are still very limited in Indonesia. Therefore, this study aims to analyse the effect of radiotherapy on the hematopoietic system in NPC patient based on the leukocyte count, hemoglobin concentration, and platelet count. Method: This study was an observational analytic study with cross sectional design using medical records of NPC patients that undergo full cycle of radiotherapy at the Teaching Hospital of Hasanuddin University in 2016-2018. The collected data analysed by using Friedman method. Results: Of the 41 patients included in this study, the mean significant difference on complete blood test parameter post-radiotherapy was only found in the leukocyte count (p<0,05) compared to the hemoglobin and platelet count variable (p>0,05). Discussion: Radiation on the bone marrow will cause a depression in the number of blood cells due to the destruction of hematopoietic stem cells and progenitor which are very sensitive to radiation. Based on the level of sensitivity to radiotherapy, leukocytes are the most radiosensitive, followed by platelets then erythrocytes. Conclusion: Radiotherapy has a significant effect on the changes of leukocyte count in patients with NPC. Keywords: Complete blood test, nasopharyngeal carcinoma, radiotherapy
Co-Authors Ahmad Fachry Toaha Aton Prasetya Sibala' Eddy Zulfikar Imam Hermansyah Juranah Juranah Ruland DN Pakasi Uleng Bahrun William Chandra Papendang William Hamdani