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KANKER OVARIUM DISGERMINOMA Hegaria Rahmawati; Darmawaty ER; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.390

Ovarian cancer is a female reproductive organ malignancy and the second most common gynaecological type cancers. World Health Organisation classifies ovarian cancer based on their origin: superficial stroma-epithelium tumour, cord-stroma sex tumour, and germ cell tumour originated from germinal cells (yolk sac). Epithelium type of ovarian cancer is common, while the germinal type is rare and can be found in teenagers and young women aged 16-20 years old. A case of suspected dysgerminomas ovarian cancer grade IIIA was reported in a 12 years old girl. The diagnosis was established by tumour markers, USG/CT Scan of abdomen, surgery, and frozen section evaluations. The reviewer expected better survival prognosis after surgery and three cycles of chemotherapy combinations were executed. The evaluations of when serial tumour markers CA-125 were suggested during chemotherapy to detect any recurrences factors possibility of the related cancer.

ANALYSIS OF MEAN PLATELET VOLUME IN TYPE II DIABETIC PATIENTS WITH VASCULAR COMPLICATION (Analisis Mean Platelet Volume Pasien Diabetes Melitus Tipe II dengan Komplikasi Vaskuler) Mustakin Mustakin; Liong Boy Kurniawan; Nurahmi Nurahmi; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1236

Penyakit Diabetes Melitus (DM) merupakan kelainan yang tersebar luas di seluruh dunia. Penyakit DM tipe 2 dengan komplikasilama berkaitan dengan gangguan pembuluh darah yang timbul mencakup yang terkait mikrovaskuler seperti: retinopati, nefropatidan neuropati, serta komplikasi makrovaskuler seperti: penyakit jantung koroner dan penyakit pembuluh darah besar. Trombosit yangberukuran besar bersifat trombogenik dan menjadi faktor kebahayaan komplikasi mikro dan makrovaskuler. Penelitian ini untukmengetahui nilai Mean Platelet Volume (MPV) di pasien DM tipe 2 dengan komplikasi makro dan mikrovaskuler dan tanpa komplikasivaskuler; serta pembanding sehat dari yang tidak berpenyakit diabetik dengan cara membandingkan. Penelitian ini bersifat potonglintang dengan menggunakan data rekam medis pasien di rumah sakit Dr.Wahidin Sudirohusodo Makassar selama masa waktuantara bulan Januari 2011−Desember 2013 terhadap 314 pasien DM tipe 2 (136 dengan komplikasi makrovaskuler dan 49 komplikasimikrovaskuler) dan 129 yang tanpa komplikasi) serta 150 pembanding sehat yang bukan DM. Rerata nilai MPV di pembanding yangnormal, DM tipe 2 tanpa komplikasi, DM tipe 2 dengan komplikasi, berturut-turut adalah: 8,77±0,52fl, 8,93±1,07fl, 10,28±1,95fl.Uji Kruskal-Wallis menunjukkan perbedaan bermakna nilai MPV antara pembanding yang normal DM tipe 2 disertai komplikasi sertaDM tipe 2 tanpa komplikasi vaskuler (p=0,000). Uji Mann Whitney menunjukkan perbedaan bermakna nilai MPV antara pembandingnonDM dengan DM tipe 2 yang disertai komplikasi (p=0,000), DM tipe 2 tanpa komplikasi dengan yang disertai komplikasi (p=0,000).Tidak ditemukan perbedaan nilai MPV yang bermakna antara pembanding normal dengan pasien DM tipe 2 tanpa komplikasi (p=0,401)dan yang disertai komplikasi makrovaskuler dan mikrovaskuler (p=0,522). Nilai MPV di kelompok DM tipe 2 dengan komplikasi lebihtinggi dibandingkan dengan DM tipe 2 tanpa komplikasi dan pembanding yang bukan DM.

ANGKA BANDING KADAR ASAM URAT AIR KEMIH TERHADAP SERUM DI DIABETES MELITUS TIPE 2 (Ratio of Urinary Uric Acid Levels and Serum Uric Acid in Type 2 Diabetes Mellitus) Amarensi Milka Betaubun; Fitriani Mangarengi; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1255

Diabetes Mellitus (DM) belongs to the group of metabolic diseases. The long-term complications of diabetes such as: diabeticretinopathy, neuropathy, and nephropathy, can be prevented or reduced by controlling the blood glucose levels. Impaired glucose tolerance,hypertension and dyslipidemia can decrease the disappearance from proximal tubules resulting in an increase in serum uric acid. The aimof the study to know the ratio of uric acid urine/serum in DMT2 with controls. This research study used a cross sectional study was andconducted on 35 samples of type 2 diabetes mellitus and 35 control samples of In- and Out-patient Clinics at the Dr. Wahidin SudirohusodoHospital, Makassar. The blood glucose, uric acid levels and urine uric acid were examined by ABX Pentra 400 (colorimetric method). Thenumber of DMT2 male patients was higher than females. Most of their age were between 50−54 years. The ratio of the urinary levels ofurine/serum UA was positively correlated to: age, sex, urine UA in DMT2 and control. Their data were analyzed with unpaired t test (p =0.00). This research showed that the ratio of urine/serum UA in DMT2 was 1.5 times than the controls. The results of this study showedan increase in the ratio of urinary levels of serum uric acid as 1.5 times higher than the controls.

MATRIKs METALOPROTEINASE-2 DI METASTASIS KARSINOMA PAYUDARA (Matrix Metalloproteinase-2 In Breast Cancer Metastastis) Besse Rosmiati; Uleng Bahrun; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1251

Matrix Metalloproteinase-2 is a family of extra cellular matrix degrading proteinases. Study results on the role of MMP-2 in breastcancer progression and metastasis are still controversial. The aim of this study was to know the MMP-2 level by analyzing in metastaticand non metastatic breast cancer patients by using a cross sectional design, it was carried out in the Wahidin Sudirohusodo, Ibnu Sina,Labuang Baji Hospitals and at the Research Unit of UNHAS Makassar from April 2012 until June 2012. The 56 breast cancer patientswere divided into two groups: metastatic and non metastatic based on their thorax photo, ultrasonography and/or bone scan results. Theywere also divided into early and advanced stage, based on their TNM staging. The matrix metalloproteinase-2 level was determined byELISA method. The result of this study showed that the mean levels of MMP-2 in metastatic and non metastatic breast cancer were 20.18ng/mL and 17.14 ng/mL, respectively. The independent sample T test showed there was a significant difference (p=0.018) in MMP-2levels between metastatic and non metastatic breast cancer. The mean level of MMP-2 in early and advanced stages was 17.10 ng/mLand 18.31 ng/mL, respectively, the independent sample T test showed no significant difference of MMP-2 level between both stages. Oneway ANOVA test showed no significant difference of MMP-2 level based on tumour size and regional lymph node infiltration. The MMP-2contributed to the metastasis in breast cancer patients. The matrix metalloproteinase-2 level in metastatic was higher than in the nonmetastatic breast cancer, so this condition could be used as a biomarker to predict the metastasis of breast cancer.

LDL TEROKSIDASI DAN KEPADATAN MINERAL TULANG (Oxidized LDL Cholesterol and Bone Mineral Density) Sheila Febriana; Yurdiansyah Yurdiansyah; Siti Rafiah; Ruland DN Pakasi; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1224

Osteoporosis is defined by low bone density and micro architectural deterioration of bone tissue with a consequent increase in bonefragility and risk of fracture. Bone Mineral Density (BMD) is a gold standard for the diagnosis of osteoporosis, which need special device,and expensive fee. So it is not routinely done, therefore another type of examination methods is needed. Oxidized LDL (oxLDL) cholesterolis the parameter correlated with diminished bone mineral density by affecting osteoblast and osteoclast. The aim of this study was toknow the role of oxLDL in diminished bone mineral density by analyzing it. Cross sectional study was held on 78 subjects during theperiod of October 2011 until June 2013 using the primary data from 30−60 years women population in Makassar, whose FPG, ALT,AST, urea and creatinine are within normal limit. Using oxLDL 6.8mU/L value as cut off, had found odds ratio increase 2.2 times with68.8% probability to suffer diminished BMD. Receiver Operating Characteristic (ROC) analysis show area under curve is 60.8%, using8.05mU/L as a cut off point resulting 68.8% sensitivity, 59.2% specifity, 76.1% positive predictive value, 50% negative predictive value,1.71 positive likelihood ratio, 0.53 negative likelihood ratio and 65.4% accuracy. Concluded that oxLDL ≥6.8mU/L increases risk tosuffer diminished BMD 2.2 times. As a diagnostic marker, oxLDL has a weak diagnostic strength and accuracy (68.8% sensitivity and59.2% specifity). The researchers have the opinion to perform a further study with larger and various population, concern on oxLDLbio availability and use it with another parameter as a panel test.

KADAR ALBUMIN SERUM PENDERITA STROK ISKEMIK DAN STROK HEMORAGIK Fasni Halil; Hj. Darmawaty ER; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.956

To differentiate the ischemic and hemorrhagic stroke with the most accurate method can be carried out by Computerized Tomography(CT) scan. However, because the restrictor on access and cost, not all patients could gain the advantage of CT scan. Examination ofalbumin is a quick and easy test. The aim of this study was to evaluate the serum albumin level in patient suffering ischemic andhemorrhagic stroke. A cross sectional study of 60 ischemic and hemorrhagic stroke patients was performed at the Neurologic Departmentof Dr. Wahidin Sudirohusodo Hospital Makassar, from March up to August 2008. Albumin – levels was measured using the colorimetricBCG method, using the Cobas Integra 400 Autoanalyser. The data were than analyzed with SPSS 11.5 software and t test. Among the60 samples of the ischemic and hemorrhagic stroke were found mean values of serum albumin level is 3.38 ± 0.120 and hemorrhagicstroke is 3.51 ± 0.0938 with p value is 0.495. There were no significantly different between the serum albumin level of the ischemicand hemorrhagic stroke patients.

ANALYSIS OF DECREASED GLUCOSE LEVEL IN STORED SAMPLES CORRELATED TO SERUM SEPARATION AND TEMPERATURE STORAGE Gustamin Gustamin; Liong Boy Kurniawan; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1157

Glukosa darah merupakan uji yang rutin untuk menilai bahaya penyakit diabetes melitus. Masalah utama yang dihadapi rumahsakit di daerah adalah sering terjadinya penundaan terhadap pemeriksaan glukosa darah, sehingga terjadi penurunan kadar glukosaakibat glikolisis. Penelitian ini bertujuan untuk mengetahui penurunan kadar glukosa darah berdasarkan suhu penyimpanan danpemisahan serum. Penelitian ini merupakan penelitian observasional dengan pendekatan kohort kajian yang dilakukan di RS Dr. WahidinSudirohusodo masa waktu Agustus 2016. Kadar glukosa diukur dengan menggunakan ABX-Pentra 400. Data yang didapat dianalisismenggunakan uji statistik Shapiro wilk dan wilcoxon. Hasil penelitian didapat dari 22 sampel darah lengkap dengan perlakuan berbedaberdasarkan suhu penyimpanan dan pemisahan serum. Hasil menunjukkan perbedaan bermakna antara glukosa serum dengan bekuanyang disimpan selama 2 jam pada suhu ruang yang mengalami penurunan sebesar 9,32 mg/dL jika dibandingkan dengan penyimpananselama 2 jam pada suhu freezer yaitu sebesar 0,8 mg/dL (p=0,000) dan jika dibandingkan dengan serum pada suhu ruang selama 2jam sebesar 1,38 mg/dL (p=0,000). Sampel untuk pemeriksaan glukosa yang tertunda sebaiknya dilakukan pemisahan antara serumdan bekuan eritrosit agar tidak terjadi penurunan glukosa.

GAMBARAN FUNGSI HATI DAN GINJAL PADA PENDERITA MALARIA Darmawaty .; Fitriani M; Ruland DN Pakasi; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.950

the prevalence of malaria disease is still high in Indonesia. It requires to be diagnosed and handled quickly to decrease themorbidity and the mortality. the purpose of this study was to evaluate the results liver and kidney function tests of malaria patients forcomplications and to know the etiology. A cross sectional method was used for this study by using medical record of malaria patientsthat at Wahidin Sudirohusodo hospital in Makassar during January to December 2006. Malaria was diagnosed based on pheripheralblood while the examination of Sgot, SgPt (DgKC method), ureum (Barthelots method) and creatinine (Jaffe's method) were doneby chemistry autoanalizer. the increasing concentration of Sgot was found on 14 patients (42.4%) which was consisted of high at 12patients, SgPt on 13 patients (39.4%), ureum on 2 patients (6.1%) and creatinine on 11 patients (33.3%). Plasmodium falciparum wasfound on 18 patients (54.5%) and Plasmodium vivax on 15 patients (45.5%). the Sgot, SgPt, ureum, and creatinine concentrationsmostly exist in normal range, this indicated that liver and kidney damage was still mild. the etiology of malaria disease was Plasmodiumfalciparum and Plasmodium vivax, it was found from examination of pheripheral blood. there was no significant different in this studyfor the increasing of Sgot, SgPt, ureum and creatinine concentrations based on plasmodium etiology.

KADAR INTERLEUKIN-8 KANKER PAYUDARA Juranah Juranah; Yuyun Widaningsih; William Hamdani; Ruland DN Pakasi; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.471

Metastasis is the major cause of increased morbidity and mortality in breast cancer. Interleukin-8 has a contribution in the spread of the tumour cells. This study was aimed to know IL-8 levels in patients with metastasic and non metasatic breast cancer by analyzing. A cross sectional study was performed at the Dr. Wahidin Sudirohusodo, Ibnu Sina and Labuang Baji hospitals during September to December 2011. Laboratory examinations were done in the Research Centre of the Medical Faculty, University of Hasanuddin. Fiftysix (56) subjects with breast cancer were examined. The results showed that the levels of IL-8 in metastatic and non metastatic breast cancer were 13.73 pg/mL and 10.48 pg/mL respectively. Mann-Whitney test showed no significant difference of IL-8 level between them, (p=0.09). When the subjects were divided into early and advance stages, the mean levels of IL-8 were 8.035 pg/mL and 12.052 pg/mL, respectively, showing a significant difference by Mann-Whitney test (p=0.009). Based on this research, the level of IL-8 can be considered as a marker in predicting the prognosis of breast cancer. A further research in cohort studies which specific metastasis crawl method is advised by the researchers, these are suggested to allow the determination of the risk factors.

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