Gilbert Sterling Octavius
Faculty Of Medicine, University Of Pelita Harapan, Karawaci, Tangerang, Banten, Indonesia

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PENGUNAAN KONSEP METABOLOMICS DENGAN 1H NMR SPEKTROSKOPI SEBAGAI BIOMARKER TERBARU DALAM SKRINING DISPEPSIA FUNGSIONAL Gilbert Sterling Octavius; Timotius Ivan Hariyanto; Prio Wibisono; Theo Audi Yanto
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 1 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.1 Edisi April - Sep
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Abstract

Pendahuluan: Dispepsia fungsional merupakan sebuah penyakit gastrointestinal yang tidak hanya menganggu kualitas hidup dari pasien tetapi juga secara finansial; Penyakit ini hanya dapat ditegakkan melalui diagnosis eksklusi dan memenuhi kriteria Roma III. Metabolomics merupakan sebuah komponen yang penting dalam bidang biologi sintetis untuk memahami hasil-hasil metabolisme. Salah satu teknik yang menggunakan konsep metabolomics adalah 1H NMR spektroskopi yang dapat dimanfaatkan untuk menemukan biomarker tertentu yang tidak dapat dideteksi melalui uji laboratorium biasa. Tujuan dari penelitian ini adalah untuk mengetahui biomarker yang dapat digunakan untuk mendeteksi pasien dispepsia fungsional dengan menggunakan 1H NMR dengan cara melakukan tinjauan pustaka dari beberapa jurnal. Pembahasan: Dari hasil tinjauan kami, 1H NMR spektroskopi menunjukkan perubahan yang signifikan dari hasil plasma pasien untuk gula darah, HDL, LDL, VLDL dan metabolit lainnya. Dibandingkan dengan kontrol, pasien dispepsia fungsional menunjukkan penurunan yang signifikan dari kadar kadar asam laktat, Leu/Ile, asam lemak tidak jenuh, glutamine dan β -glukosa. Sebaliknya, kadar PtdCho, HDL, acetoacetate, proline, α– glukosa dan LDL/VLDL menunjukkan peningkatan yang signifikan pada pasien dispepsia fungsional dibandingkan dengan pasien kontrol. Leu/Ile dan Ptdcho terpilih menjadi biomarker potensial setelah melalui berbagai uji validasi dan kuantifikasi Kesimpulan: 1H NMR spektroskopi dapat digunakan sebagai biomarker untuk mendeteksi pasien dispepsia fungsional. Akan tetapi, diperlukan penelitian lebih lanjut terhadap Leu/Ile dan Ptdcho sebagai biomarker potensial yang dapat digunakan untuk skrining pasien dispepsia fungsional secara klinis.
Clinical Usefulness of Telehealth: A Literature Review from the Perspective of Medical Specializations Gilbert Sterling Octavius; Lie Rebecca Yen Hwei
Cermin Dunia Kedokteran Vol 48 No 12 (2021): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i12.174

Abstract

Telehealth uses interactive technology and telecommunication to provide health care and share medical knowledge between the users. Information is transferred from one site to another electronically. Telehealth enables physicians to access the integrated electronic medical records in treating patients. Telehealth can be used for diagnostic, therapeutic, preventive measures, self-education, and self-monitoring of patients’ health. Telehealth enables users to interact collaboratively with each other. Telehealth enables multiple medical specialties in providing health care services to a more significant population of patients. Telehealth is also a cost-effective method in providing health care services in both urban and rural areas. Telehealth may be an answer to problems associated with poverty, rural areas, and lack of medical personnel. The purpose of this article is to give insights into the use of telehealth in multiple medical specialties and its positive outcomes. Telehealth memanfaatkan teknologi dan telekomunikasi yang interaktif untuk memberikan akses pelayanan kesehatan dan berbagi pengetahuan seputar dunia medis bagi penggunanya. Informasi ditransfer dari satu situs ke situs lain secara elektronik. Telehealth memungkinkan dokter untuk mengakses catatan medis elektronik terintegrasi saat merawat pasien. Telehealth dapat digunakan untuk tindakan diagnostik, terapeutik, pencegahan, serta pendidikan dan pemantauan mandiri bagi para pasien. Telehealth memungkinkan pengguna untuk berinteraksi secara kolaboratif satu sama lain. Telehealth juga memungkinkan beberapa spesialisasi medis dalam memberikan layanan perawatan kesehatan kepada populasi pasien yang lebih banyak. Telehealth juga merupakan metode yang hemat biaya dalam menyediakan layanan perawatan kesehatan di daerah perkotaan dan pedesaan. Telehealth dapat menjadi jawaban atas masalah yang terkait dengan kemiskinan, daerah pedesaan, dan kurangnya tenaga medis. Tujuan artikel ini adalah untuk memberikan wawasan tentang penggunaan telehealth dalam berbagai spesialisasi medis dan hasil positifnya.
Exclusive breastfeeding practice and its association with breastfeeding self-efficacy among mothers giving birth during the COVID-19 pandemic in Indonesia : A Brief Report Angelina, Angelina; Lesmanadjaja, Alicya; Agung, Fransisca Handy; Octavius, Gilbert Sterling
Journal of Maternal and Child Health Vol 6, No 4 (2021)
Publisher : Journal of Maternal and Child Health

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Abstract

Background: Breast milk is the best nutri­tion for most infants, and current recommen­dations encourage mothers to keep giving breast milk during the COVID-19 pandemic.Subjects and Method: This is an analytic cross-sectional study involving mothers givi­ng birth since March 2020 and their infants aged under 6 months. An online-based ques­tion­naire, including the Breast­feeding Self-Efficacy Scale-Short Form (BSES-SF), was distributed through social media from April to September 2020. The dependent variable was exclusive breast­feeding rate, and the independent vari­ables were BSES-SF score, mother working status, educational level, place of birth, birth method, and COVID-19 status.Results: There were 113 respondents, and the rate of exclusive breastfeeding was 79.6%. Self-efficacy score in mothers who give exslusive breastfeeding (Mean= 58.4; SD= 0.8) was higher than non exclusive breast­feed­ing (Mean= 44.8; SD= 13.4) and it was statisfically significant (p <0.001).Conclusion: This study showed that during the COVID-19 pandemic exclusive breast­feedi­ng rate might remain high in popular­tions with good breastfeeding self-efficacy.Keywords: exclusive breastfeeding, breast­fee­ding self-efficacy, child nutrition, COVID-19Correspondence: Angelina. Child Health Department, Faculty of Medicine, Universitas Pelita Harapan. Jendral Sudirman 20, Tangerang, Banten, Indonesia. Email: Angelina.fk@uph.edu.Journal of Maternal and Child Health (2021), 06(04): 436-443https://doi.org/10.26911/thejmch.2021.06.04.05
The Effects of COVID-19 Information Sources and Knowledge, Attitude, and Behaviour on Vaccination Acceptance Rivaldo Steven Heriyanto; Theo Audi Yanto; Gilbert Sterling Octavius; Haviza Nisa; Catherine Ienawi; H. Emildan Pasai
Journal of Community Empowerment for Health Vol 6, No 1 (2023): Vol 6, No 1 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.78698

Abstract

Introduction: This study intends to assess the impact of COVID-19 information-related sources, as well as one's knowledge, attitude, and behavior concerning vaccine acceptance, vaccine hesitancy, and vaccine refusal in a single vaccination site in Jambi, IndonesiaMethods: We conducted a cross-sectional study with total sampling in Puskesmas Putri Ayu, Jambi. The inclusion criteria are adults (>18 years) vaccinated with CoronaVac. Our exclusion criteria were refusal to participate in the study for any reason, contraindicated to COVID-19 vaccine administration, and receiving the second vaccine jab.Results: We include 245 respondents with a slight female predominance (53.5%). The majority is in the age group of 26-35 years old (20.8%). In the multivariate analysis, having a family member with≥2 comorbidities is almost six times more likely (OR 5.99, 95%CI 1.84-19.54; p-value = 0.003) to put a respondent in the vaccine hesitance and refusal group. Respondents who trust in friends or family are 2.25 times more likely (95%CI 1-5.04; p-value = 0.048) to belong in the vaccine hesitance and refusal group. Respondents who trust the internet are 0.45 times more likely to belong in the vaccine hesitance and refusal group (95%CI 0.21-0.96; p-value = 0.04). Lastly, respondents with poor knowledge are 0.58 times more likely (95%CI 0.38-0.88; p-value = 0.011) to belong in the vaccine hesitance and refusal group.Conclusions: This finding will be relevant to increasing vaccination uptake by targetting family members with comorbidities and devising a strategy to make their peers trust the COVID-19 vaccine to increase the uptake.
Validation of Indonesian Version of Telehealth Usability Questionnaire (TUQ) Gilbert Sterling Octavius; Theo Audi Yanto
Journal of Community Empowerment for Health Vol 6, No 2 (2023): Vol 6, No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.77796

Abstract

Introduction: Indonesia is the 4th most populous country globally, with 250 million people spread across 17.508 islands. Despite its strong economic growth, the disparity in poverty increases as the cost of medical care shot up. With inadequate medical care worker-to-patient ratio, telehealth is an alternative to providing healthcare in rural areas with similar or even better satisfaction rates. The lack of a standardized questionnaire in the Indonesian language encouraged the authors to validate Telehealth Usability Questionnaire (TUQ) into the Indonesian language.Methods: A cross-sectional study was done while translation and adaptation of telehealth usability questionnaires were made according to WHO protocol.Results: A total of 102 respondents' data were obtained, which comprised 73.5% female. The overall alpha coefficient was 0.958. The Kaiser–Meyer–Olkin (KMO) sampling test was satisfactory (KMO = 0.926), and the Bartlett test of sphericity was significant (Chi-square = 1835.043; df = 210; p < 0.001). Ease of use and learnability had the highest Cronbach's alpha coefficient (0.907), while reliability had the lowest Cronbach's alpha coefficient (0.794).Conclusion: In conclusion, this questionnaire is one of the first ones, if not the first one, to be validated in the Indonesian language. This set of questions will help assess the usability of the expanding number of telehealth programs available in Indonesia and allow comparisons to determine which features make them more acceptable to users