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All Journal Medical Journal of Indonesia INDONESIAN JOURNAL OF PHARMACY
Poerwono Rahardjo
Department of Medicine, Medical Faculty, Gadjah Mada University/Dr. Sardjito General Hospital, Yogyakarta.
Medicine & Pharmacology

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Effect of the combination of C.domestica extract and essential oil of C.xanthorrhiza roxb. on leucocyte count in synovial fluid compared to that of pyroxicam Kertia, Nyoman; A.D., Imono; ., Mufrod; Catur, Eny; Rahardjo, Poerwono; Asdie, Ahmad Husain
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (193.783 KB) | DOI: 10.14499/indonesianjpharm0iss0pp155-161

Abstract

Osteoarthritis (OA) is the most prevalence rheumatic disease. The non steroidal antiinflamatory drugs display some side effect especially on the gastrointestinal tract, liver, kidney and blood clotting. Kunyit (Curcuma domestica L.) and temulawak (Curcuma xanthorrhiza Roxb.) as natural herbal remedies are developed for antiinflammation, antioxidant and cholagoga. The aim of this present research was to study the effect of combination of Curcuma domestica extract and essential oil of Curcuma xanthorrhiza Roxb on the leucocyte count in the synovial fluid of patient with osteoarthritis compared to that of pyroxicam. A double blind randomized clinical trial was used and conducted at Dr. Sardjito Hospital Yogyakarta. After washed out period the knee synovial fluid was aspirated and the leucocyte count was examined. Patients were randomized for receiving piroxicam capsule 10 mg twice daily or combination of 3,66 ± 0,65 % w/w curcuminoid extract of Curcuma domestica L.and 25 ml essential oil containing curcumen, bergamoten germacren B, Curserenon, Germacron, Xanthorrizol as a major component with 27,64 ± 0,85 % relative concentration of xanthorrhizol each capsule; two times a day for two week period. At the end of this study the synovial fluid was examined. Decreasing the inflamation of synovial area was parrallel with decreasing leucocyte count by 174.56 ± 161.73 per mm3 (p
Hyperinsulinemia and cardiovascular risk factors in stroke patients Wiyono, Paulus; Rahardjo, Poerwono; Widiana, I Gde R.; Purnama, Purnama
Medical Journal of Indonesia Vol 6, No 1 (1997): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (643.282 KB) | DOI: 10.13181/mji.v6i1.803

Abstract

[no abstract available]
Co-Authors Ahmad Husain Asdie Eny Catur, Eny I Gde Raka Widiana I Nyoman Kertia Imono A.D., Imono Mufrod ., Mufrod Paulus Wiyono Purnama Purnama