Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Indonesia
Eka Umayasari
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Aktivitas Antihipertensi dari Ekstrak Etanol Daun Dewandaru (Eugenia uniflora L.) pada Tikus Putih Jantan yang Diinduksi Adrenalin Eka Umayasari; Lucia Vita Inandha Dewi; Mamik Ponco Rahayu
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (758.167 KB) | DOI: 10.31001/jfi.v12i1.72

Abstract

Hypertension is a condition in which an individual develops above normal blood pressure, when systolic blood pressure exceeds 140 mmHg and diastolic exceeds 90 mmHg. Hypertension becomes health problem in the world. Dewandaru leaves contained flavonoid, saponin and tannin. This research aimed to find out the antihypertensive activity of dewandaru leaves ethanol extract and to find out the most optimum dose of dewandaru ethanol extract (Eugenia uniflora L.). Dewandaru leaves ethanol extract was obtained through extraction using maceration method and using ethanol 96% solvent. This study employed 25 male white rats divided into 5 groups: groups I (control with kontrol negatif, II (control with captopril), III (ethanol extract at 0.3 mg/200 gBW dose), IV (ethanol extract at 0.6 mg/200 g BW dose), V (ethanol extracts at 1.2 mg/200 g BW dose). The tested animal was made hypertensive with adrenaline induction intraperitoneally. The blood pressure measurement was conducted on the week-3 using blood pressure analyzed. The analysis used in this research was ANOVA with Dunnet T3 advanced test. From the result of research, it could be found that all doses of dewandaru leaves ethanol extract had antihypertensive activity. Dose 1.2 mg/200 g BW had effect equivalent to captopril’s.
Co-Authors Lucia VIta Inandha Dewi Mamik Ponco Rahayu