Garuda - Garba Rujukan Digital

Gambaran Reaksi Obat Yang Tidak Dikehendaki pada Pengobatan Tuberkulosis di Puskesmas Kabupaten “X” Yogyakarta dan Hubungannya dengan Kepatuhan Minum Obat Lucia VIta Inandha Dewi; Lukman Hakim; Sismindan Sismindan; Ngatidjan Ngatidjan; Soni Prabowo Putra
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25870

Pemantauan Reaksi Obat Tidak Dikehendaki (ROTD) perlu dilakukan pada pasien tuberkulosis untuk menjamin keamanan selama pengobatan dan meningkatkan kualitas hidup pasien mengingat banyaknya jenis obat yang digunakan dan durasi pengobatan yang cukup lama. Penelitian ini bertujuan untuk mengetahui gambaran ROTD yang terdiri dari : jenis, jumlah kejadian, dan waktu timbul, serta mencari hubungan antara terjadinya ROTD dengan kepatuhan minum obat. Penelitian ini merupakan penelitian observasional dengan rancangan studi kohort terhadap 33 pasien yang memenuhi kriteria inklusi, di beberapa puskesmas kabupaten X Yogyakarta, pada tahun 2017. Data ROTD didapat dari hasil wawancara dan pengisian lembar isian yang terdiri dari 12 macam pilihan ROTD mayor dan minor, data kepatuhan didapat dari pengisian kuesioner dengan metode Morisky Modification Adherence Scalle (MMAS)-8. Dari keseluruhan subyek yang diteliti 66,6 % mengalami ROTD, 4,5% mengalami lebih dari 5 jenis ROTD, 31,8% mengalami 3 jenis, 27,27% mengalami 2 jenis, dan 31,8% mengalami 1 jenis. Dari 12 jenis ROTD yang diamati, terdapat 51 kejadian ROTD, dengan 11,76% kategori mayor yaitu gatal pada kulit dan gangguan penglihatan, serta 88,2% kategori minor. Gangguan pencernaan adalah jenis ROTD paling banyak dialami yaitu sebanyak 69% kejadian, sementara kram otot dan demam masing-masing sebesar 1,9%. Dari 66,6% subyek yang mengalami ROTD tercatat kejadian timbulnya ROTD terbanyak terjadi pada 1 hingga 4 minggu setelah minum obat. Hasil uji chi-square antara kejadian ROTD dan tingkat kepatuhan menunjukkan tidak terdapat hubungan antara kejadian ROTD dengan tingkat kepatuhan, taraf sig 0,602 > 0,05. Kejadian ROTD dialami oleh beberapa subyek penelitian terdiri dari ROTD mayor dan minor, namun tidak mempengaruhi tingkat kepatuhan minum obat pasien.

Perbandingan Efektivitas Antibiotik Thiamfenikol dan Ofloksasin pada Demam Tifoid Pasien Rawat Jalan Di RS Panti Waluyo Purworejo Lucia Vita Inandha
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Typhoid fever is one of the bacterium infections frequently found in many developing countries including Indonesia. The case also occurs in Purworejo based on the data obtained from Panti Waluyo Hospital, Purworejo. The hospital mostly use thiampenicol and ofloxacin antibiotics for the medication of it. The research project was aimed to recognizing the efficacy of them based on the result of clinical observation toward the patients after taking the antibiotics. The research was conducted using prospective experimental method on the patients in the on going care installation in Panti Waluyo Hospital Purworejo. They had been diagnosed as having typhoid fever. The research subjects were divided into two groups: 25 subjects got 500 mg thiamphenicol antibiotic wich was taken three times a day, the other 25 subjects got 200 mg ofloxacin taken twice a day. The observation was done since the first day the patients took the medicine until their subsequent visit for the check-up. The clinical result of the patient were noted and investigated to see how many days the fever and other clinical symptoms finally came to an end after taking the antibiotics. The result demonstrated that the means of the end of the fever for the patients who had taken thiampenicol occured on day 3.44, whereas the means of the end of the fever for the patients who had taken ofloxacin occured on the second day. The statistical analysis reveals that there is a significant difference between the two antibiotics regarding the end of the fever. The means of other clinical symptoms concerning the typhoid fever for the patients who had taken thiampenicol occured on day 3.16, whereas the means of these symptoms for the patients who had taken ofloxacin occured on day 3.08. The statistical analysis demonstrates that there is no significant difference toward the duration of the end of other clinical symptoms generated by both antibiotics.

Uji Aktivitas Minyak Atsiri Bunga Kamboja (Plumeira acuminate Ait) sebagai Repellent terhadap Nyamuk Aedes aegypti Tika Novita Sari; Lucia Vita Inandha Dewi; Dyah Susilowati
Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Repellent is a material that has the ability to protect humans from mosquito bites. Repellent have contains active ingredients that can interrupt mosquitoes ability to find their host. Essensial oil of frangipani flower contains has active materials, such as geraniol, linalool and sitronelol. This study aimed to determine the ability of frangipani oil as repellent to prevent bites of Aedes aegypti. This repellent activity was conducted with inserting the hand alternately between treatment and control into test cage repellent each containing 50 mosquitoes. It was about 3 hours treatment with observation for 5 minutes at each intervals of 1 hour. The oil concentration used were 1%, 3%, 6%, 12,5% and 25% with DEET 13 % as a positive control and distilled water as negative control. The Observation data was any concentration of power protection essential oil. Analysis of the data has been using by one â€“ way ANOVA test (p= 0,000), followed by a different average Tukey HSD with Î± = 0,05 (p= 0,000). Effective dose value (ED50) for protection against Aedes aegypti by 50% was calculated by probit analysis. The result of this study was the frangipani oil has a potential effect as repellent to Aedes aegypti with ED50 of 1,3357%. The higher concentration will increase the potential repellent, where as the longer it will reduce the potential repellent treatment.

Aktivitas Antihipertensi dari Ekstrak Etanol Daun Dewandaru (Eugenia uniflora L.) pada Tikus Putih Jantan yang Diinduksi Adrenalin Eka Umayasari; Lucia Vita Inandha Dewi; Mamik Ponco Rahayu
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Hypertension is a condition in which an individual develops above normal blood pressure, when systolic blood pressure exceeds 140 mmHg and diastolic exceeds 90 mmHg. Hypertension becomes health problem in the world. Dewandaru leaves contained flavonoid, saponin and tannin. This research aimed to find out the antihypertensive activity of dewandaru leaves ethanol extract and to find out the most optimum dose of dewandaru ethanol extract (Eugenia uniflora L.). Dewandaru leaves ethanol extract was obtained through extraction using maceration method and using ethanol 96% solvent. This study employed 25 male white rats divided into 5 groups: groups I (control with kontrol negatif, II (control with captopril), III (ethanol extract at 0.3 mg/200 gBW dose), IV (ethanol extract at 0.6 mg/200 g BW dose), V (ethanol extracts at 1.2 mg/200 g BW dose). The tested animal was made hypertensive with adrenaline induction intraperitoneally. The blood pressure measurement was conducted on the week-3 using blood pressure analyzed. The analysis used in this research was ANOVA with Dunnet T3 advanced test. From the result of research, it could be found that all doses of dewandaru leaves ethanol extract had antihypertensive activity. Dose 1.2 mg/200 g BW had effect equivalent to captoprilâ€™s.

the Faktor-Faktor yang Berpengaruh terhadap Adverse Drug Reaction pada penggunaan Obat Anti Tuberkulosis Lucia Vita Inandha Dewi
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.903

Adverse Drug Reaction (ADR) in the treatment of tuberculosis can reduce the quality of life and compliance of patients, long-term treatment has a risk of ADR, to prevent dangerous ADRs need to be monitored properly, the predictors that affect ADR are very important to be sought as an effort to prevent the incidence ADR. This study was a cross-sectional study conducted on pulmonary tuberculosis patients at the Public Health Center (PKM) of Bantul Regency Yogyakarta, inclusion criteria were patients who received fixed-dose combination tuberculosis (KDT), age> 17 years old, ADR monitoring was carried out since the month of two treatments up to the 6th month by interview method for each control patient to the PKM. Data processing was performed by multinomial regression multivariate tests. The results showed that ADR occurred in 58% of the old age group; 51.8% of the middle age group and 50% of the young age group, there was no significant effect of age on ADR in this study. Based on sex, ADR occurred in 58.5% of men, and 47.3% of women, with no significant effect of gender on ADR. Based on BMI, ADR occurred in the underweight, normal, and overweight groups with a percentage of 78%, 26%, and 40% there was a significant influence between BMI and the incidence of ADR, p-value 0.01 OR = 7,650 (2,350-24,898) CI = 95 %. Based on the BTA ADR group occurred in the positive and negative BTA groups with a percentage of 52% and 62%, there was no significant effect between the BTA and the ADR incidence Key words : Adverse Drug Reaction, Tuberculosis, Fixed-dosed combination-Antituberculosis Drug (FDC)

Antihiperglikemik Kombinasi Minyak Biji Mahoni (Swietenia mahogani (L.) Jacq-Glibenklamid pada Tikus Diinduksi Aloksan DIONYSIUS ANDANG ARIF WIBAWA; KETUT WIRIANA; LUCIA VITA INANDHA DEWI; RATNA AGUNG SAMSUMAHARTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.841 KB)

Diabetes mellitus (DM) is a chronic disorder metabolism of glucose in the body. Mahogany seeds (Swietenia mahagoni (L.) Jacq.) reportedly contains fl avonoids, alkaloids and saponins which can be used as therapy of diabetes mellitus. This study aimed to determine the eff ects of antihyperglycemic combination of mahogany seed oil-glibenclamide in male rats hyperglycemiced by alloxan induction. The mahogany seed oil liquefaction processed by using hydrolic pressed instrument 100 psi pressure. This study using Wistar strain male rats aged 2-3 months as many as 35 heads which were divided into 7 groups: group I (normal control) with distilled water added, while the II-VII group with alloxan induced intraperitoneal 140 mg/kg body weight two times. Group II as a negative control was added 0.5% CMC, group III was added glibenclamide 0.09 mg/200 g BB, IV groups oiled mahogany seeds 2 mL/200 g BW, group V, VI, and VII were added a combination of mahogany seed oil glibenclamide with each ratio (75%: 25%, 50%: 50%, 75%: 25%). The distribution of the test preparation 1 times a day for 12 days and blood glucose measurement performed on days 3, 6, 9, and 12. Data has been analyzed by oneway ANOVA (signifi cant p <0.05). The results obtained the combination of mahogany seed oil-glibenclamide provides eff ect to reduction in blood glucose levels induced male rats alloxan, the combination group mahoni-glibenclamide seed oil have equal activity in lowering blood glucose levels with a single chemical drug glibenclamide. Mahogany seed oil is potentially antidiabetic.

Hubungan Tingkat Pendapatan dan Pendidikan dengan Perilaku Masyarakat Melakukan Swamedikasi Gastritis di Kelurahan Nunleu Kota Kupang: Relationship of Income and Education Level with the Decision of the Community to Self-Medicate Gastritis in Nunleu Village Kupang City Marisa Stifani Mandala; Lucia Vita Inandha; Inaratul Rizkhy Hanifah
Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 1 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Swamedikasi setiap tahun meningkat, data pada Badan Pusat Statistik menyatakan Provinsi Nusa Tenggara Timur tahun 2018 sampai 2020 berturut-turut sebesar 60,93%, 59,72%, dan 61,31%. Seseorang melakukan swamedikasi karena biaya dan waktu terbatas, serta minimnya akses pelayanan kesehatan. Pendidikan dan pendapatan diduga berpengaruh dalam perilaku swamedikasi. Penyakit gastritis merupakan salah satu penyakit yang sering dilakukan swamedikasi, BPS menyatakan dari 10 penyakit utama terbanyak di Kota Kupang, gastritis menempati urutan kedua dengan jumlah 21.760 kasus. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pendidikan, pendapatan terhadap perilaku swamedikasi gastritis Masyarakat Kelurahan Nunleu, Kota Kupang.Metode penelitian yaitu observasional analitik dengan menggunakan rancangan cross sectional study. Penelitian dilakukan di kelurahan Nunleu, Kota Kupang tahun 2021 dengan metode pengambilan sampel adalah purposive sampling menggunakan instrumen kuesioner dengan jumlah sampel 332 sesuai kriteria inklusi. Hasil penelitian menunjukan responden memiliki pendidikan terakhir terbanyak yaitu perguruan tinggi (53,0%) dan pendapatan terbanyak <RP.1.5000.000 (51,5%). Responden yang memiliki pendidikan tinggi (63,3%) memiliki perilaku swamedikasi gastritis yang baik (47,9%), dan berpendapatan rendah (51,8%) memiliki perilaku swamedikasi gastritis baik (45,8%.). Uji statistic chi-square memperoleh hasil terdapat hubungan yang signifikan antara tingkat pendidikan dengan perilaku (p-value 0,000 < 0,05) demikian juga tingkat pendapatan dengan perilaku masyarakat melakukan swamedikasi gastritis (p-value 0,000 < 0,05).

Gambaran Efek Samping Kontrasepsi Hormonal pada Akseptor Keluarga Berencana di Wilayah Puskesmas X Kabupaten Karanganyar Lucia Vita Inandha Dewi; Eunike Yuvita Purbosari; Inaratul Rizkhy Hanifah
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1556

Hormonal contraception use in the Family Planning (KB) program can cause side effects that interfere with health, reduce comfort, and cause the program to stop, in several previous studies, weight gain and menstrual disorders have been reported as the most side effects, but it is suspected that there are still side effects. For others that have not been reported, a complete description of the incidence of side effects is needed to consider the selection of a safe and suitable type of contraception for the acceptor. The purpose of the study was to describe the incidence of side effects and the percentage of events based on the type of hormonal contraception. This research is an observational descriptive study involving 327 respondents according to the inclusion criteria, using a questionnaire that has been tested for validity and reliability. The study was conducted on family planning acceptors who are in the working area of â€‹â€‹Puskesmas X Surakarta. Analysis of the results was carried out univariately by the percentage of the number of adverse events based on the type and type of hormonal family planning used. The results showed that the incidence of side effects in the form of weight gain was 51.8%,, menstrual disorders 38.8%, dizziness 9.1%, nausea 7%, acne 6,1%, and anxiety was 3%. Based on the type of hormonal contraception, the incidence of side effects experienced by acceptors of 3-month injections was 74,3 %, 1-month injections 38,8%, pills 29,9%, and implants was 6,4%.

Hubungan Efek Samping Obat Dengan Length Of Stay (LOS) Pasien Jantung Koroner Di Rumah Sakit â€œXâ€ Inaratul Rizkhy Hanifah; Asa Puspagiri Setiyasih; Lucia Vita Inandha Dewi
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1790

Coronary heart disease (CHD) is caused by the narrowing and blockage of blood vessels that carry blood to the heart. CHD is listed as the highest deadly disease by WHO. CHD treatment is carried out long-term and uses a combination of several drugs, so there is a risk of drug side effects. Length of stay (LOS) is one indicator of successful therapy for CHD patients. However, no correlation studies of LOS with the incidence of drug side effects in CHD patients. Therefore, the purpose of the study was to analyze the potential side effects that occur in CHD therapy and to find the relationship with LOS in the "X" Hospital in Surakarta in 2021. This research uses a descriptive observational method by retrospectively taking patient medical record data that match the inclusion criteria. The sample in this study was 81 patients whose results were tabulated and analyzed univariately by describing the results based on the percentage of events. The reference in this study was Meyler's Side Effects of Drugs guidelines and several supporting journals. To find the relationship between the incidence of drug side effects with LOS using SPSS with the chi-square test. The result show that 23 patients (28%) had the incidence of side effects from CHD treatment. Potential side effects arising in patients include muscle pain; weakness; fever; diarrhea; dizziness; constipation; and nausea-vomiting; are 43.48%, 26.09%, 13.04%, 4.35%, 4.35%, 4.35%, 4.35%, respectively. There was no correlation between side effects and LOS (p=0.803; OR=1,132).

Identifikasi Polimorfisme Gen N-Asetiltransferase 2 (NAT2) Pada Suku Batak Ezra Pasaribu; Jason Merari Paranginangin; Lucia Vita Inandha Dewi
Health Information : Jurnal Penelitian Vol 15 No 1 (2023): Supplemen
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Indonesia has various ethnic groups spread from Sabang to Merauke consisting of more than 300 ethnic groups, Research on the TB gene in Javanese (40%) Sundanese (15.50%), Malay (3.7%), Batak (3.6%), Madura (3%) and Betawi (2.88%). The aim is to determine the presence of polymorphisms in the NAT2 gene of healthy Batak subjects along with the types of polymorphisms and types of acetylators. The impact of NAT2 polymorphisms are drug toxicity, peripheral neuropathy. The method uses the RFLP method with a sample of 10 Batak tribes. Blood samples were isolated by DNA using the Wizard® Genomic DNA Purification Kit then RFLP PCR using restriction enzymes: Taq1, Kpn1, BamH1 and electrophoresis. The RFLP of the Kpn1 restriction enzyme used a 100bp marker. Taq1 obtained NAT2*4 and the mutant allele NAT2*6A. BamH1 obtained NAT2*4 and the mutant allele NAT2*7B. There are NAT2 gene polymorphisms in the Batak tribe, namely NAT2*4/*5B, NAT2*4/*6A, NAT2*4/*7B, NAT2*5B/*5B and NAT2*7B/*7B and the type of NAT2 gene polymorphism in the Batak tribe. namely medium acetylator NAT2*4/*5B (20%), NAT2*4/*6A (33.3%) and in NAT2*4/*7B (20%), slow acetylator NAT2*5B/*5B (13,3%) and NAT2*7B (13.3%). The types of acetylators in the Batak tribe of North Sumatra province are medium and slow acetylators.

Title

Found 10 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 10 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 10 Documents
Search