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All Journal Al-Insyirah Midwifery : Jurnal Ilmu Kebidanan (Journal of Midwifery Sciences) Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Indonesian Journal of Global Health research Jurnal Kesehatan Abdurrahman
Aryanti Aryanti
STIKES Abdurahman Palembang
Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Indonesian Journal of Global Health research

 1 
The Effect of Fraction and Active Compounds of Momordica Balsamina L. on Bacteria Salmonella Typhi Causing Salmonellosis Aryanti Aryanti; Rinda Lamdayani
Indonesian Journal of Global Health Research Vol 3 No 1 (2021): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.964 KB) | DOI: 10.37287/ijghr.v3i1.291

Abstract

Salmonella typhi is one of the bacteria that causes typhus. The handling of typhus by bacteria generally requires the provision of antibacterial substances, namely antibiotics. Excessive and irrational use of antibiotics causes bacteria to be resistant so that over time the benefits of using antibiotics will decrease. Pare leaves are an alternative treatment for various diseases, one of which is antibacterial. The purpose of this study was to determine the ability of bitter melon leaf fractions and active compounds against Salmonella typhi bacteria with various concentrations. This study was a laboratory experimental study through in vitro. The subjects in this research were Salmonella typhi bacteria. The results of this study indicated that the concentration of ethyl acetate fraction is a strong fraction between n-hexane and water methanol fractions in inhibiting Salmonella typhi bacteria. The determination of the active compound group from the purification of the ethyl acetate fraction of forest bitter melon leaves obtained flavonoid active compounds with an Rf value of 0.1 in the eluent n-hexane: ethyl acetate (7:3). The minimum inhibitory concentration (MIC) of ethyl acetate fraction was 125 μg/ml, while the MIC of flavonoid compounds was 62.5 μg/ml against Salmonella typhi bacteria. From the results of the equivalence test of the ethyl acetate fraction with ampicillin against Salmonella typhi bacteria, it showed that the concentration of the active fraction of ethyl acetate 1 μg/ml was equivalent to 0.007 μg/ml ampicillin, while the equivalence of flavonoid compounds was obtained 1 μg/ml concentration of active compounds equivalent to 0.011 μg/ml ampicillin.
Change in White Male Rats’ Weight and Epididimic Histology Due to the Provision of White Turmeric Extract and Fraction Rinda Lamdayani; Aryanti Aryanti
Indonesian Journal of Global Health Research Vol 3 No 1 (2021): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (580.823 KB) | DOI: 10.37287/ijghr.v3i1.301

Abstract

The low participation of Men in the family planning program is due to the limited choice of male contraceptives that can be used. This makes experts trying to find a way that is safe for men, one way is to switch plants that can inhibit the spermatogenesis. One of the traditional medicines that has been studied and has anti-fertility effectiveness is the white turmeric plant. This study aimed to determine the effect of extracts and fraction of white turmeric on changes in weight and histology of white male rats (Rattus norvegicus) epididymis. This research was an experimental study using a completely randomized design (CRD). The samples in this study were 25 white male rats that met the inclusion criteria which were divided into 5 groups, each group consisting of 5 rats obtaining a dose of 300 mg/kgBW/day, treated for 48 days and stopped for surgery on the day 49. After that, the analysis was carried out using One Way Anova test and continued with Duncan's test. The provisions of extracts and fractions of white turmeric can reduce the weight and histological structure of the epididymis of the head, corpus, and cauda.
The Effect of Fraction and Active Compounds of Momordica Balsamina L. on Bacteria Salmonella Typhi Causing Salmonellosis Aryanti Aryanti; Rinda Lamdayani
Indonesian Journal of Global Health Research Vol 3 No 1 (2021): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.964 KB) | DOI: 10.37287/ijghr.v3i1.291

Abstract

Salmonella typhi is one of the bacteria that causes typhus. The handling of typhus by bacteria generally requires the provision of antibacterial substances, namely antibiotics. Excessive and irrational use of antibiotics causes bacteria to be resistant so that over time the benefits of using antibiotics will decrease. Pare leaves are an alternative treatment for various diseases, one of which is antibacterial. The purpose of this study was to determine the ability of bitter melon leaf fractions and active compounds against Salmonella typhi bacteria with various concentrations. This study was a laboratory experimental study through in vitro. The subjects in this research were Salmonella typhi bacteria. The results of this study indicated that the concentration of ethyl acetate fraction is a strong fraction between n-hexane and water methanol fractions in inhibiting Salmonella typhi bacteria. The determination of the active compound group from the purification of the ethyl acetate fraction of forest bitter melon leaves obtained flavonoid active compounds with an Rf value of 0.1 in the eluent n-hexane: ethyl acetate (7:3). The minimum inhibitory concentration (MIC) of ethyl acetate fraction was 125 μg/ml, while the MIC of flavonoid compounds was 62.5 μg/ml against Salmonella typhi bacteria. From the results of the equivalence test of the ethyl acetate fraction with ampicillin against Salmonella typhi bacteria, it showed that the concentration of the active fraction of ethyl acetate 1 μg/ml was equivalent to 0.007 μg/ml ampicillin, while the equivalence of flavonoid compounds was obtained 1 μg/ml concentration of active compounds equivalent to 0.011 μg/ml ampicillin.
Change in White Male Rats’ Weight and Epididimic Histology Due to the Provision of White Turmeric Extract and Fraction Rinda Lamdayani; Aryanti Aryanti
Indonesian Journal of Global Health Research Vol 3 No 1 (2021): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (580.823 KB) | DOI: 10.37287/ijghr.v3i1.301

Abstract

The low participation of Men in the family planning program is due to the limited choice of male contraceptives that can be used. This makes experts trying to find a way that is safe for men, one way is to switch plants that can inhibit the spermatogenesis. One of the traditional medicines that has been studied and has anti-fertility effectiveness is the white turmeric plant. This study aimed to determine the effect of extracts and fraction of white turmeric on changes in weight and histology of white male rats (Rattus norvegicus) epididymis. This research was an experimental study using a completely randomized design (CRD). The samples in this study were 25 white male rats that met the inclusion criteria which were divided into 5 groups, each group consisting of 5 rats obtaining a dose of 300 mg/kgBW/day, treated for 48 days and stopped for surgery on the day 49. After that, the analysis was carried out using One Way Anova test and continued with Duncan's test. The provisions of extracts and fractions of white turmeric can reduce the weight and histological structure of the epididymis of the head, corpus, and cauda.
Co-Authors Mirta i Andan Rinda Lamdayani Tiara Fatrin Titin Apriyani Winda Afriani Yona Sari