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All Journal The Indonesian Biomedical Journal ACI (Acta Cardiologia Indonesiana) Heart Science Journal Eureka Herba Indonesia
Ardian Rizal
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : The Indonesian Biomedical Journal

 1 
Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation Ardian Rizal; Ferry Sandra; Muhamad Rizki Fadlan; Djanggan Sargowo
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1244

Abstract

BACKGROUND: Atrial fibrillation (AF) could be triggered by inflammation and oxidative stress. Ganoderma lucidum has an active substance in the form of β-glucan that can reduce inflammatory process and oxidative stress in rats. The objective of this study was to evaluate the effect of Ganoderma lucidum polysaccharide peptide (GLPP) in paroxysmal AF subjects with parameters of anti-inflammatory antioxidant, electrocardiography and health-related quality of life (HRQoL).METHODS: A randomized closed-label clinical trial with pre- and post-test design was conducted. After AF subjects selection, the subjects were randomized, interviewed and veni-punctured to isolate blood plasma. AF Subjects were then treated with placebo or GLPP for 90 days. Post-test blood plasma was collected on the following day after the 90th day. Then anti-inflammatory and antioxidant parameters were measured. After that, echocardiographic and HRQoL assessments were performed.RESULTS: A total of 38 subjects, 11 males and 27 females, completed the study with no significant changes in diets, physical activities, or medications. Comparing to control, the 90-days GLPP-treated subject characteristics were significant difference in systolic blood pressure, heart rate, malondialdehyde, high-sensitivity C-reactive protein, tumor necrosis factor-a, interleukin (IL)-1b, IL-6, primary (P)-wave dispersion, P-max, physical functioning, limitation to physical health, energy/fatigue, pain, and physical limitation.CONCLUSION: GLPP has several potential effects in AF subjects, including anti-inflammatory, antioxidant, and atrial remodelling, so that HRQoL of AF subjects could be improved. Hence, GLPP could suggested as a potential supplementing agent for AF management.KEYWORDS: atrial fibrillation, Ganoderma lucidum, inflammation, antioxidant, atrial remodelling, quality of life
β-1,3/1,6-D-glucan of Mycelia Extract Posses Renal Protection Potential and Reduces Nitric Oxide in Obese Subjects Djanggan Sargowo; Ardian Rizal; Yoga Waranugraha; Anna Fuji Rahimah; Putri Annisa Kamila; Mohammad Rizki Fadlan; Icmi Dian Rochmawati; Cik Kahadi; Yuke Fawziah Kemala; Bunga Bella Pratiwi; Susanti Lara Dewi; Wiwit Nurwidyaningtyas
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1876

Abstract

BACKGROUND: Obesity has been widely reported to be associated with loss of kidney function. The efficacy of β-1,3/1,6-D-glucan as a traditional medicine for the improvement of inflammation and vascular status in obesity has known. However, there have been no further studies that prove the effect of β-1,3/1,6-D-glucan in inhibiting kidney injury as an impact of chronic inflammation exposure on obesity. This study aimed to investigate the impact of β-1,3/1,6-D-glucan from mycelia extract supplementation on renal function improvement based on serum nitric oxide (NO), ureum, and creatinine levels.METHODS: This was a randomized control trial study involving 69 obese subjects treated with or without β-1,3/1,6-D-glucan supplementation. The serum NO, ureum, and creatinine levels of the subjects were measured at baseline and post-treatment using enzyme-linked immunosorbent assay (ELISA) and then statistically analyzed with paired T-test.RESULTS: Although slightly decrease, no significant difference was found between the ureum and creatinine level at the baseline and and post-treatment (p=0.806, p=0.306, respectively) after β-1,3/1,6-D-glucan supplementation. Serum NO levels significantly decrease after treatment of β-1,3/1,6-D-glucan (p<0.001).CONCLUSION: Current study concludes that β-1,3/1,6-D-glucan from mycelia extract does not significantly lower urea and creatinine level, however, significantly able to reduce the serum NO concentration in obese subjects. Therefore, β-1,3/1,6-D-glucan from mycelia extract might have the renal protection potential in obesity.KEYWORDS: β-1,3/1,6-D-glucan, Ganoderma lucidum, renal function improvement, obesity
Ganoderma lucidum Polysaccharide Peptide Reduces Oxidative Stress and Improves Renal Function in Patient with Cardiometabolic Syndrome Syanindita Puspa Wardhani; Khilmi Ainun Nadliroh; Al Mazida Fauzil Aishaqeena; Fahriza Abid Sonia; Achmad Guntur Hermawan Suryo Adji; Intan Masyfufah Hanim; Rizkia Milladina Hidayatulloh; Anna Fuji Rahimah; Ardian Rizal; Peter Sugita; Ferry Sandra; Djanggan Sargowo
The Indonesian Biomedical Journal Vol 15, No 2 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i2.2137

Abstract

BACKGROUND: Cardiometabolic syndrome is a risk factor for the development of diseases related to cardiovascular disease and decreased renal function. Ganoderma lucidum polysaccharide peptide (GLPP) has been reported to have anti-inflammatory and antioxidant properties. The current study was conducted to investigate the role of GLPP in inflammatory, oxidative stress and renal function markers of cardiometabolic subjects.METHODS: A randomized double-blinded perspective control trial with pre-post design was conducted. Cardiometabolic syndrome subjects were treated with placebo or GLPP for 60 days. Blood serum was collected from each subject before the first capsule consumption and one day after the last capsule consumption. Serum tumor necrosis factor (TNF)-α, high-sensitivity-C-Reactive Protein (hs-CRP) and malondialdehyde (MDA) levels were measured using enzyme-linked immunosorbent assay, while superoxide dismutase (SOD) level was measured using colorimetric assay. Serum urea and creatinine levels were measured using a clinical analyzer. The Cockroft-Gault formula was used to calculate estimated glomerular filtration rate (eGFR).RESULTS: Compared with the control group, the MDA level was significantly reduced, while the SOD level was significantly increased in the GLPP treatment group. Furthermore, serum urea and creatinine were lowered, while eGFR was increased in the GLPP treatment group.CONCLUSION: Treatment of GLPP for 60 days could be beneficial for lowering oxidative stress and improving renal function of patients with cardiometabolic syndrome.KEYWORDS: Ganoderma lucidum, cardiometabolic syndrome, inflammation, oxidative stress, renal function
Co-Authors Achmad Guntur Hermawan Suryo Adji Adhika Prastya Wikananda Aditha Satria Maulana Adriyawan Widya Nugraha Al Mazida Fauzil Aishaqeena Aloysius Yuwono Suprapta Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Aris Munandar ZI Aris Munandar Zulkifli Ismail Budi Satrijo Budi Satrijo Bunga Bella Pratiwi Cholid Tri Tjahjono Cik Kahadi Dea Arie Kurniawan Diah Ivana Sari Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Estyka Ratu Fahmy Rusnanta Fahmy Rusnanta Fahriza Abid Sonia Fajar, Jonny Karunia Fandy Hazzy Alfata Faris Wahyu Nugroho Ferry Sandra Ferry Sandra Fitranti Suciati Laitupa Harris Kristanto Heny Martini Heny Martini Heny Martini Icmi Dian Rochmawati Indra Prasetya Indra Prasetya Intan Masyfufah Hanim Khilmi Ainun Nadliroh Mohammad Rizki Fadlan Mohammad Saifur Rohman Mohammad Saifur Rohman Mohammad Saifur Rohman Mohammad Saifur Rohman Muhamad Rizki Fadlan Muhammad Saifur Rohman Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Olivia Handayani Olivia Handayani Peter Sugita Puspa Lestari Putri Annisa Kamila Putri Annisa Kamila Rizkia Milladina Hidayatulloh Sasmojo Widito Sasmojo Widito Sasmojo Widito Sasmojo Widito Sasmojo Widito Sasmojo Widito Sasmojo Widito Seprian Widasmara Setyasih Anjarwani Setyasih Anjarwani Setyasih Anjarwani Sri Winarsih Susanti Lara Dewi Syanindita Puspa Wardhani Taufieq Ridlo Makhmud Tonny Adriyanto Valerinna Yogibuana Veny Kurniawati Wiwit Nurwidyaningtyas Yoga Waranugraha Yuke Fawziah Kemala