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All Journal Pharmaciana: Jurnal Kefarmasian Edumaspul: Jurnal Pendidikan Molekul: Jurnal Ilmiah Kimia JURNAL ILMU KEFARMASIAN INDONESIA
Salni Salni
Universitas Sriwijaya
Chemical Engineering, Chemistry & Bioengineering Chemistry Education Languange, Linguistic, Communication & Media Medicine & Pharmacology Other

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Journal : JURNAL ILMU KEFARMASIAN INDONESIA

 1 
Activity Tests of Bioactive Material of Salung Leaf (Psychotria viridiflora Reinw. Ex. Blume) against Salmonella thypi Bacteria In Vitro And In Vivo SALNI SALNI; HANIFA MARISA; HARMIDA HARMIDA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.075 KB)

Abstract

Activity test of bioactive material of Salung leaf (Psychotria viridiflora Reinw. ex. Blume) against Salmonella thypi in vitro and in vivo has been carried out. Bioactive material was obtained from the maceration and followed by fractionation of liquid-liquid fractionation. Antibacterial activity test performed in vitro to determine the value of the minimum inhibitory concentration (MIC) and in vivo to determine the ability of bioactive cure diarrhea in in rats (Rattus norvegicus) infected by Salmonella typhi. Treatment of bioactive material given is 0, 10, 50 and 100 mg kg-1 of weight. The results showed that the MIC of salung leaf’s bioactive material to Salmonella typhi was 250 μg mL-1. Bioactive ingredient at dose of 10 and 50 mg kg-1 were able to decrease the number of bacterial colonies to 4.14x106 cfu g-1 and 5.4x105 cfu g-1, less than 5.04x106 cfu g-1 as control. Bioactive material in weight of 100 mg kg-1 of weight could reduce the population of Salmonella typhi to zero after 12 days of treatment. The ability to reduce the amount of bacterial colonies of the bioactive material 100 mg kg-1 of weight is equal to the ability of positive control chloramphenicol 10 mg kg-1 of weight.
Efek Ekstrak Dan Fraksi Daun Salung (Psychotria viridiflora Reinw. ex. Blume) Sebagai Sitotoksit, Antiproliferasi dan Penginduksi Apoptoksis pada Sel Kanker Serviks HeLa Salni Salni; Arlina Ismaryani; Arum Setiawan; Triwani Triwani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.789 KB) | DOI: 10.35814/jifi.v16i2.528

Abstract

Cervical cancer ranks second of cancer that affects women in the world and the first order for women in developing countries. Plant Salung (Psychotria viridiflora Reinw. Ex. Blume) have been used for generations to treat various diseases. The purpose of the study to determine the effects of leaf extracts and fractions salung as the anti-proliferation and inducer of apoptosis in HeLa cervical cancer cells. Concentration of extracts and fractions of 640; 320; 160; 80; 40 µg/mL, while cisplatin using a concentration of 200; 100; 50; 25 µg/mL. The results showed IC50 extract value 380.7 µg/mL. n-hexane fraction amounted to 229.3 µg/mL. ethyl acetate fraction of 116.8 µg/mL, and amounted to 562.8 µg/mL fraksi methanol water, so that the ethyl acetate fraction had enough categories active cytotoxic activity seen from the IC50. To further test the researchers only tested the active fraction is the fraction of ethyl acetate. Results ethyl acetate fraction doubling time is 58, which means replicating or proliferating cells on hour to 58 while the cells replicate cisplatin on the hour to 64.5 and the control cell on the hour to 41. Results of flowcytometry showed ethyl acetate fraction induce apoptosis by 72.82% while cisplatin 87.96%. It can be concluded that the extracts and fractions of leaves salung have a cytotoxic effect, acts as an anti-proliferation and inducer of apoptosis in HeLa cervical cancer cell.
Co-Authors Arlina Ismaryani Arum Setiawan Astri Indah Lestari Hanifa Marisa HANIFA MARISA HARMIDA HARMIDA Laila Hanum Masayu Farah Diba Putri Mayasari Sri Nita Subandrate Triwani Triwani