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All Journal SAR (Soedirman Accounting Review): Journal of Accounting and Business Jurnal Gizi dan Pangan Soedirman (JGPS) Molekul: Jurnal Ilmiah Kimia JAE (Jurnal Akuntansi dan Ekonomi) Journal of Accounting, Finance, Taxation, and Auditing (JAFTA) Global Financial Accounting Journal Indonesian Journal of Islamic Business and Economics (IJIBE) Journal of Economic, Business and Engineering (JEBE) Jurnal Ekonomi, Bisnis, dan Akuntansi Jurnal RAK (Riset Akuntansi Keuangan) Jurnal Ilmiah Akuntansi dan Keuangan Fokus Bisnis: Media Pengkajian Manajemen dan Akuntansi
Puji Lestari
Universitas Jenderal Soedirman
Religion Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Molekul: Jurnal Ilmiah Kimia

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Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium Hernayanti Hernayanti; Sri Lestari; Saryono Saryono; Puji Lestari
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.654 KB) | DOI: 10.20884/1.jm.2021.16.3.775

Abstract

Cadmium is  a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups  with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2
Co-Authors Agung Praptapa Agung Prayogi Bambang Agus Pramuka Christiana Nia Iskandar Christina Tri Setyorini Dona Primasari Eko Suyono ELIADA HERWIYANTI Hernayanti Hernayanti Irianing Suparlinah Lilik Handaya Eka Margani Pinasti Minadi Wijaya Romandhon Romandhon Saryono Saryono Shabira Nurulizzah Sahida Sri Hartiyah Sri Lestari Sully Kemala Octisari Sully Kemala Octisari Sully Kemala Octisari Supriono Supriono Suyata Suyata Thiya Septriana Warsidi Warsidi Wita Ramadhanti