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All Journal IJAAM (Indonesian Journal of Anti-Aging Medicine)
AAGP Wiraguna
Department of Dermatology and Venerology, Faculty of Medicine, Universitas Udayana
Medicine & Pharmacology

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Cream jengkol seed extract 8% (Archidendron pauciflorum) inhibited the increase melanin amount in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet-B rays Rafiah Sirikit Saenong; Wimpie Pangkahila; AAGP Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.85

Abstract

Introduction: The exposure to UV rays on the skin causes hyperpigmentation and premature aging. Hyperpigmentation is caused by an increase of melanin count in the epidermal skin layer. The abundant natural resources that come from Indonesia and have the potential to be good antioxidants are jengkol seeds. The aim of this research was to prove that 8% jengkol seeds (Archidendron pauciflorum) extract cream could inhibit the increase of melanin count in the skin of guinea pig (Cavia porcellus) exposed to ultraviolet B rays. Method: This design of this research is an experimental research with the post-test only control group design. This research used 36 male guinea pigs (Cavia porcellus), local strains, aged 3 months with a body weight of 300-350mg, divided into 2 groups, each of which was 18. The research was conducted for 2 weeks, then a tissue biopsy was carried out as a histological preparation and then the Masson-Fontana staining was carried out. Results: The results showed that the mean value of melanin count for the base cream group was 20.851 ± 1.777%, whereas in the treatment group which applied with 8% jengkol seeds extract cream showed the mean value of 1.289 ± 0.391% (p <0,001). This indicated that the base cream group has a bigger melanin count than the jengkol seeds extract group. Conclusion: The 8% jengkol seeds (Archidendron pauciflorum) extract cream inhibited the increase of melanin
The application of kenikir (Cosmos caudatus) extract cream to inhibit the increase of melanin counts in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet B Olivia Olivia; I Gusti Made Aman; AAGP Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.86

Abstract

Introduction: Hyperpigmentation is caused by the increase of melanin in the skin layer, especially the epidermal layer. Kenikir (Cosmos Caudatus) is a plant that can be used as an antioxidant and anti-melanogenic. The aim of this research was to prove the effectiveness of the cream with 4% kenikir (Cosmos Caudatus) extract to inhibit the increase of melanin in the skin of guinea pig (Cavia porcellus) exposed to ultraviolet B. Methods: The kenikir (Cosmos Caudatus) that have been extracted in Food Laboratory of Agriculture Faculty in Universitas Udayana became the main requirement in this research. This research employed an experimental design with post-test only control group method. To conduct this study, 36 male guinea pigs (Cavia porcellus), local strain, aged 3 months with 300-350mg body weight divided into 2 groups, each of which was 18. The duration of irradiation was 3 times a week with a total irradiation dose of 65 mJ/cm2. After 2 weeks of research, then the back skin tissue of guinea pigs biopsied as the histological preparations and then the Masson-Fontana staining was performed. The results were analyzed by using descriptive analysis, the test of normality and homogeneity and also independent t-test. Results: The control group (P0) (20,57±2,90%) had a bigger average melanin count than the treatment group (P1) (1,41±0,437%) significant statistically (p<0.001). Conclusion: this research is the cream with 4% of kenikir (Cosmos Caudatus) extract can inhibit the increase of melanin counts in the skin of a male guinea pig (Cavia porcellus) exposed to Ultraviolet B.
The 20% of petai seed (Parkia speciosa) extract cream in inhibited the increase of melanin counts in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet B Nining Triyana Darise; Wimpie Pangkahila; AAGP Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.87

Abstract

Introduction: The exposure to UV may cause skin disorders, including hyperpigmentation. Petai seeds are categorized as traditional medicinal plants that have anti-inflammatory and antioxidant effects, such as flavonoids, tannins, phenols and vitamin C which have the function of inhibiting the tyrosinase enzyme and the synthesis of melanin. The aim of this research was to prove that a 20% of Petai seed (Parkia speciosa) extract cream could prevent the increase of melanin counts in the skin of Guinea Pigs (Cavia porcellus) exposed to UV-B. Method: This research employed an experimental study through a randomized post-test only control group design that used 36 male guinea pigs (Cavia porcellus) that divided into 2 (two) groups each of which were 18 guinea pigs. In order to find out the mass, melanin stained with Masson-Fontana, the melanin count was showed in percent. The results of this research were then analyzed and used descriptive analysis, data normality, data homogeneity, and comparability tests. Results: The results indicated that the mean was 20.543 ± 3.344%, whereas, in the treatment group that smeared by 20% of petai seed extract cream, the mean value was 1.533 ± 0.518% (p <0.001). This indicated that the treatment group had a smaller melanin count than the control group. Conclusion: Based on the results of this research, it can be concluded that 20% of petai seed extract cream inhibited the increase of melanin counts in guinea pigs’ skin exposed to UV-B.
Co-Authors I Gusti Made Aman Nining Triyana Darise Olivia Olivia Rafiah Sirikit Saenong Wimpie I Pangkahila