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All Journal IJAAM (Indonesian Journal of Anti-Aging Medicine)
Sriwiyanti Sriwiyanti
Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar
Medicine & Pharmacology

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Ethanol extract of red fruit (Pandanus conoideus lam.) improved lipid profile of dyslipidemic-male wistar rats (Rattus norvegicus) Sriwiyanti Sriwiyanti; I Gusti Made Aman; Gde Ngurah Indraguna Pinatih
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.88

Abstract

Introduction: Dyslipidemia is one of aging- related disease associated with unhealthy food such as high calories and fat. Pandanus Conoideus Lam. with high antioxidant capacity might ameliorates dyslipidemia phenotypes. This study aimed to prove that ethanol extract of red fruit improves lipid profiles of dyslipidemic-rats (Rattus norvegicus). Methods: This was an experimental study with a pretest-posttest control group design, using 14 wistar rats males. Rats were then divided into 2 groups (n= 7). The first group was treated with aquabidestilata 1 mL for 30 days (P0). The second group was treated with extract of red fruit ethanol of 168 mg/200 gr BW for 30 days (P1). Results: The control group (P0) treated with aquabidestilata, total cholesterol levels increased into 221.48 ± 3.64 mg/dl (p <0.05), triglyceride levels elevated into 132.92±3.01 mg/dl (p <0.05), HDL levels depleted into 22.83 ± 2.26 mg/dl (p <0.05), and LDL levels was increased from 76.77 ± 3.33 mg / dl to 78.63 ± 2.84 mg / dl (p <0.05). In contrast, the red fruit ethanol extract in treatment group (P1) experienced decrease on total cholesterol level into 118.41 ± 2.15 mg/dl (p <0.05), triglyceride levels into 91.81 ± 2.71 mg/dl (p <0.05), and LDL levels into 45.85 ± 2.59 mg/dl (p <0.05), and elevation on HDL levels from 25.77 ± 1.36 mg/dl to 55.76 ± 2.35 mg/dl (p <0.05). Conclusion: This study indicated that administration of ethanol extract of red fruit (Pandanus conoideus lam.) improved lipid profiles of dyslipidemic-rats (Rattus norvegicus).
Co-Authors Gde Ngurah Idraguna Pinatih I Gusti Made Aman