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Seniwati Dali
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Jl.Perintis Kemerdekaan km 10, Makassar-90245
Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science

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Isolasi, Identifikasi, Karakterisasi Dan Uji Toksisitas Senyawa Metabolit Sekunder Fraksi Nonpolar Akar Babandotan (Ageratum conyzoides L) Muhammad Irmawan; Frederyk Mandey; Seniwati Dali
Indonesian Journal of Chemical Research Vol 6 No 1 (2018): Edisi Bulan Juli (Edition For July)
Publisher : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2018.6-muh

Abstract

Ageratum Conyzoides L. has a toxic and bioactive component as anti-cancer and especially for the root, it has anti-tumor. In order to figure out the active component, it is necessary to do four steps; isolation, identification, characterization, and toxicity essay Brine Shrimp Lethality Test (BSLT) of non-polar fraction Ageratum conyzoides L plant. Isolation method consist of four parts; extraction, partitioning of Kupchan method, fractionation, and purification. Fractionation method uses press column chromatography (KTT). Furthermore, purification process uses thin layer chromatography (TLC) and characterization with spectroscopy FTIR, 1H-NMR and 13C-NMR. Then characterization utilizes spectroscopy FTIR, 1H-NMR and 13C-NMR. The toxicity essay toward Artemia Salina Leach n-hexane fraction and dichloromethane fraction showed that the fraction had toxic properties with number of LC50 are 0,0237 and 4,642 µg/mL respectively. Moreover, n-hexane fraction has succeed in isolating Stigmasterol compound shaped white crystalline needles with 19.6 mg weight, 143-144 °C melting point and and had toxic properties with number of LC50 are 30,33 µg/mL.
Co-Authors Frederyk Mandey Muhammad Irmawan