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All Journal Jurnal Pendidikan Kewarganegaraan Nexus Kedokteran Klinik J-EBIS (Jurnal Ekonomi dan Bisnis Islam) Indonesian Journal of Medicine Journal of Maternal and Child Health
Muhammad Riza
niversitas Lambung Mangkurat
Economics, Econometrics & Finance Education Medicine & Pharmacology Public Health Other

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Journal : Nexus Kedokteran Klinik

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Hubungan Lama Sakit dengan Status Gizi Anak Penderita Talasemia di RSUD Dr. Moewardi Anisa, Ilma; Riza, Muhammad; Moelyo, Annang Giri
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Systemic complications that occur in children with thalassemia like hepatomegaly, hemosiderosis, bone deformities can affect nutrition disorder and growth retardation. The longer someone has suffered thalassemia, the more likely for the systemic disorder occurred. The aims of this study to find out the correlation between duration of illness with nutritional status of children with thalassemia in Dr. Moewardi Hospital. Methods: This is an observational analytic study using cross sectional design which was conducted from April to May 2013. Thirty children with thalassemia in the Dr. Moewardi Hospital were fulfill the restriction criteria. The duration of illness was acquired from medical record, while the nutritional status was obtained through measurements of weight, height, and the mid-upper arm circumference. The correlation between the duration of illness, gender, blood transfusion, iron chelating agents, splenomegaly, and 1 day food recall with nutritional status was analyzed by using Spearman test followed by the multivariate logistic regression analysis. Results: Spearman test analysis showed no significant correlation between duration of illness with nutritional status in children with thalassemia according to the weight/age and height/age indicator (p = 0,403 and p = 0,408). From the result of analysis on correlation between gender, blood transfusion, iron chelating agents, splenomegaly, and 1 day food recall with nutritional status according to the weight/age and height/age indicator (p > 0,05). Conclusions: There is no significant correlation between the duration of illness with the nutritional status of children with thalassemia according to the weight/age and height/age indicator in Dr. Moewardi Hospital. There is no correlation between gender, blood transfusion, iron chelating agents, splenomegaly, and 1 day food recall with nutritional status. Keywords: Duration of Illness, Nutritional Status, Thalassemia 
Hubungan Antara Kadar Feritin Dengan Kadar ALT dan AST Pada Pasien Thalasemia di RSUD Dr. Moewardi Prabandari, Valentina Lakhsmi; Riza, Muhammad; Wijayanti, Lilik
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Thalassemia major patients need a regular blood transfusion that may cause an iron overload and vital organ dysfunction. This was an observational analytic study to analyze the relationship between ferritin level and transaminase enzymes level in thalassemia patients at Dr.Moewardi General Hospital. A positive relation may remind doctor to pay attention of liver function in thalassemia major patients. Methods: The research was an observational analytic study with cross sectional approach during April-June 2013 in Dr. Moewardi General Hospital. The samples was taken using exhaustive sampling and all were children with beta thalasemia major. These patients had a regular blood transfusion, high ferritin level (>1000 ng/l) and iron chelating agents usage. Ferritin level as independent variable was measured with ELFA method. Transaminase enzymes as dependent variables were measured with IFCC method. These variables were analyzed with Pearson correlation, diagnostic odds ratio and linier regression. Results: Thirty thalassemia patients’ test results of ferritin, ALT and AST level were collected. Eighteen patients had a very high ferritin level (≥3000 ng/l) and the other twelve patients’ ferritin level were between 1000-3000 ng/l. Eighteen patients had a high ALT level and seventeen patients had a high AST level. Pearson analysis showed a significant result between ferritin and ALT level (p=0.043) also between ferritin and AST level (p=0.028). Pearson correlation strengths were moderate (0.373 and 0.401). Odds ratio between ferritin level with ALT and AST level were 3.333 and 3.111. Conclusions: There was a positively moderate correlation between ferritin level and both ALT and AST level in thalassemia patients in Dr. Moewardi General Hospital. Odds ratio analysis showed that ferritin level above 3000 ng/l is a risk factor of ALT and AST level elevation. Keywords: Thalassemia, iron overload, ferritin, transaminase 
Co-Authors Annang Giri Moelyo Ayuningtyas, Dewi Sitoresmi Bambang Soebagyo Dian Agus Ruchliyadi Dini Safitri Zahara Elistasari, Endra Yustin Evalda, Putri fitriani, fatimah Hari Wahyu Nugroho Hendra Wardhana Husnia Auliyatul Umma, Husnia Auliyatul Ilma Anisa Lilik Wijayanti Prasetyadi Mawardi, Prasetyadi Prasetyorini, Budi Eko Sri Martuti Valentina Lakhsmi Prabandari