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All Journal Jurnal Fitofarmaka Indonesia Jurnal Kimia Terapan Indonesia SAINSTECH: Jurnal Penelitian dan Pengkajian Sains dan Teknologi
Rizna Triana Dewi
Research Center of Chemistry, Indonesian Institute of Scinces, Kawasan Puspiptek Serpong, Tangerang 15314, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Electrical & Electronics Engineering Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology

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Potensi Ekstrak Buah Buni (Antidesma bunius (L) Spreng) Sebagai Inhibitor Enzim α-Glukosidase La Hamidu; Partomuan Simanjuntak; Rizna Triana Dewi
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.969 KB) | DOI: 10.33096/jffi.v7i1.598

Abstract

Diabetes mellitus is still a global health problem that continues to increase rapidly and become one of the major metabolic diseases throughout the world. This study aims to determine the potential of Buni fruit as an α-glucosidase inhibitor. α-glucosidase inhibition test is carried out on a blank solution (test solution without sample/standard), acarbose solution as a comparison standard and samples are carried out in accordance with the optimization conditions obtained. The rendemen percent of green and red buni fruit extract yields are 6.35% and 3.09%, respectively. The results of the identification of secondary metabolites using TLC showed that green and red buni fruit extract contains flavonoid, phenolic and alkaloid compounds. The results of the α-glucosidase enzyme inhibition test showed that the red buni fruit extract had the highest activity compared to green buni fruit extract with an IC50 value of 85.27 ppm. 
PENGARUH LOKASI DAN PELARUT PENGEKSTRAKSI TERHADAP KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK PEGAGAN (Centella asiatica L. Urb) Nina Artanti; Rizna Triana Dewi; Faiza Maryani
Jurnal Kimia Terapan Indonesia Vol 16, No 2 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1479.245 KB) | DOI: 10.14203/jkti.v16i2.13

Abstract

Pegagan (Centella asiatica Linn Urb.) merupakan jenis tanaman yang biasa digunakan dalam industry farmasi dan kosmetik.Penelitian ini ditujukan untuk mengevaluasi pengaruh tiga lokasi asal sampel dan tiga jenis larutan pengekstraksi (methanol, etanol 96% (v/v), dan etanol 70% (v/v)) terhadap aktivitas antioksidan herbal pegagan (Centella asiaticaLinn Urb).Sampel pegagan yang digunakan pada peneltian ini berasal dari Lembang, Bandung, dan Solo.  Pada ekstrak yang diperoleh dilakukan penentuan kadar fenol total, flavonoid total, dan triterpenoid total. Aktivitas antioksidan dari ekstrak dievaluasi berdasarkan metoda peredaman radikal bebas 2,2-diphenyl-1-picrylhydrazyl (DPPH).  Hasil yang diperoleh menunjukkan bahwa simplisia pegagan asal Lembang yang diekstrak dengan etanol 70% mempunyai aktivitas antioksidan tertinggi serta kandungan fenol total dan flavonoid total tertinggi. Sedangkan simplisia pegagan asal Bandung yang diekstrak dengan pelarut metanol memiliki kandungan triterpenoid total tertinggi tetapi memiliki kandungan fenol total dan flavonoid total serta aktivitas antioksidan yang terendah.  Hasil analisa statistik menunjukkan bahwa lokasi asal simplisia pegagan dan polaritas pelarut yang digunakan untuk ekstraksi secara signifikan (p<0,05) mempengaruhi kandungan fenol total, flavonoid total dan triterpenoid total serta aktivitas antioksidan dari ekstrak pegagan.Kata kunci: ekstrak pegagan, antioksidan, polaritas pelarut Pegagan (Centella asiatica Linn Urb.) is a plant species that commonly used in the pharmaceutical and cosmetic industry. Objective of this study is to evaluate the effect of different source location and solvent polarity for the extraction to the content of total phenolic, total flavonoid total triterpenoids as well as antioxidanti activity of pegagan ((Centella asiatica (Linn.) Urb.)extracts.  Pegagan materials for this study are from three different locations: Bandung, Lembang and Solo.  Based on polarity differences methanol, ethanol 96% and ethanol 70% were used as solvent for extraction.  Antioxidant activity of the extract was evaluated based on the method of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.  Results showed that the highest total phenolic content and flavonoid content and antioxidant activity were from 70% ethanol extract from Lembang. Materials from Bandung extracted with methanol gave the highest content of total triterpenoid, however has the lowest content of total phenolic, total flavonoid and antioxidant activity.  Statistic  analysis showed that there is significant differences (p<0,05) of results of total phenolic, total flavonoid, total triterpenoid and antioxidant activity due to source location and solvent polarity. Keywords:Centella asiatica (Linn.) Urb extract, antioxidant, polarity solvent
Effect of Liquid Media Composition on Alpha-Glucosidase Inhibitory Activity from Aspergillus elegans SweF9 Hani Mulyani; Rizna Triana Dewi; Euis Filailla; Nina Artanti
Jurnal Kimia Terapan Indonesia Vol 21, No 2 (2020)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v21i2.426

Abstract

This study aims to determine the effect of liquid media composition on the inhibitory activity of α-glucosidase from endophytic fungus Aspergillus elegans SweF9 isolated from seaweed (Macroalgae Euchema sp). Fermentation was carried out in three types of liquid media, namely: potato dextrose broth (PDB), potato malt peptone (PMP), and Czapek-dox broth (CDB), which was incubated for 10 days at room temperature, with static conditions. Ethyl acetate solvents were used to extract active metabolites from fungal biomass and filtrate from each media. Antidiabetic activity was measured based on inhibition of enzyme α-glucosidase. The results showed that filtrate extract of A. elegans SweF9 which was cultured on the media PDB showed highest inhibitor activity to the α-glucosidase enzyme with an IC50 value of 1.74 µg / mL compared to other extracts. Based on these results, the PDB media is an appropriate medium for culturing A. elegans SweF9  to produces secondary metabolites that can be used as a new source of antidiabetic agents.
Potensi Antidiabetes pada Daun, Kulit Batang dan Biji Mahoni (Swietenia macrophylla King) Tiah Rachmatiah; Dina Permatasari; Rizna Triana Dewi
SAINSTECH: JURNAL PENELITIAN DAN PENGKAJIAN SAINS DAN TEKNOLOGI Vol 25 No 2 (2015): Jurnal Penelitian dan Pengkajian Sains dan Teknologi
Publisher : Institut Sains dan Teknologi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.708 KB) | DOI: 10.37277/stch.v25i2.104

Abstract

Abstrak---Diabetes melitus merupakan penyakit dimana terjadinya peningkatan kadar glukosa darah dalamtubuh yang melebihi batas normal. Dalam upaya mencari pengobatan dari bahan alam untuk diabetes dansalah satunya yang sudah digunakan dimasyarakat adalah biji mahoni. Tujuan penelitian ini adalah untukmengetahui aktivitas antidiabetes ekstrak etanol daun, kulit batang dan biji mahoni (Swietenia macrophyllaKing) terhadap enzim α-glukosidase secara in vitro. Bahan uji yang digunakan adalah kulit batang, daun danbiji mahoni (Swietenia macrophylla King) yang diperoleh dari pohon yang tumbuh di tepi jalan raya daerahBogor, Jawa Barat. Pengujian aktivitas antidiabetes secara in vitro dilakukan dengan metodepenghambatankerja enzim α-glukosidase dengan substrat p-nitrofenil-α-D-glukopiranosida. Serbuk simplisia daun, kulitbatang dan biji mahoni (Swietenia macrophylla King) dimaserasi menggunakan etanol 96%. Penapisangolongan senyawa kimia pada serbuk dan ekstrak etanol daun dan kulit batang memperlihatkan adanyakandungan saponin, tanin, flavonoid dan steroid/triterpenoid, namun serbuk dan ekstrak etanol bijimengandung alkaloid, steroid/triterpenoid dan pada serbuknya juga terdapat saponin. Hasil penelitianmenunjukkan bahwa ekstrak etanol dari daun, kulit batang dan biji mahoni mempunyai aktivitas antidiabetesterhadap enzim α-glukosidase dengan nilai IC50 18,78 μg/ml, 21,31 μg/ml dan 1049,05 μg/ml.
Co-Authors Dina Permatasari Euis Filailla Faiza Maryani Hamidu, La Hani Mulyani Nina Artanti Partomuan Simanjuntak Tiah Rachmatiah