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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences journal of internal medicine Jurnal Kedokteran Brawijaya CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Penyakit Dalam Indonesia
Achmad Rudijanto
Magister Manajemen Rumah Sakit Fakultas Kedokteran Universitas Barawijaya Malang
Agriculture, Biological Sciences & Forestry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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PENGARUH HIPERGLEMI TERHADAP PERAN SITOSKELETON (CYTOSKELETON) SEBAGAI JALUR TRANSDUKSI SIGNAL (SIGNAL TRANSDUCTION) Rudijanto, Achmad; Kalim, Handono
journal of internal medicine Vol. 7, No. 3 September 2006
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.269 KB)

Abstract

Intracellular signal transduction occurs through cascades of reactions involving dozens of proteins that transmit signalsfrom the cell surface, through a crowded cellular environment filled with organelles and a filamentous cytoskeleton, to specifictarget. For most characterized signal transduction pathway, the initial signaling event and the end point are well known. In order tofully understand intracellular signal transduction, it is essential to know the intermediate signaling molecules and to understandhow information flows from one to the next. The cytoskeleton , an interconnected assembly of actin (microfilament), intermediatefilament and microtubule networks that extend throughout the entire cell, is involved in intracellular signal transduction.Individual proteins of the cytoskeleton might participate directly in signal transduction by linking two or more signaling proteinand might also provide a macromolecular scaffold, which spatially organizes components of a signal transduction cascade.Diabetes mellitus is an increasingly common disease. Absolute or relative deficiencies of insulin are common in this disease.Insulin has been suggested to play a key regulatory role in the functional organization of actin filaments. The microtubules are alsothe targets of insulin. A chronic insulin deficiency may could lead to impairment in the organization of the cytoskeleton. Thiscould entail a compromised or slower action of some activated enzymes in cells, affect to intracellular signal transduction.
Prolonged-heated High-Fat Diet Increase the Serum LDL Cholesterol Level and Induce the Early Atherosclerotic Plaque Development in Wistar Rats Yurina, Valentina; Yunita, Ema Pristi; Raras, Tri Yudani Mardining; Rudijanto, Achmad; Handono, Kusworini
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

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Abstract

Rats are one of the most widely used animal models in health research. However, since rats are relatively resistant to atherosclerosis, the transgenic rats often used to study atherosclerosis in rats. Our study suggests a prolonged-heated lipid to induce atherosclerosis in rats, therefore provide a more low-cost option to study atherosclerosis in rats. Aims of this study is to compare the effect of heated high-fat diet (HFD) to the LDL and HDL cholesterol level and foam cell formation in the Wistar rat animal model. Rats were divided into three groups, control group was given with the normal diet, and the other two treated groups received oxidized HFD (heated HFD) and HFD, respectively. The heated HFD contain lard that was previously heated at 190°C for 24 h. Diet was given for 8 weeks. The serum LDL and HDL cholesterol level were measured before and 4th and 8th weeks after treatment with help of colorimetric measurement. The aorta analyzed for the foam cell formation after HE staining using the light microscope.  The prolonged- heated HFD significantly increased the LDL cholesterol from the 4th week of the treatment (p = 0.023). The rats aortic from HFD and heated HFD treated groups showed a mononuclear cells infiltration and the early foam cell formation. The heating process of the lipid caused lipid oxidation which significantly increased the LDL cholesterol level of the animal model and foam cells formation. This study suggests that Wistar rats with heated HFD could demonstrated early atherosclerosis plaque development.
PENGARUH PEMBERIAN CORNMEAL DAN CORNMEAL-SOY TERHADAP KADAR KOLESTEROL DALAM SERUM TIKUS Harti, Leny Budhi; Rudijanto, Achmad; Kristianto, Yohanes
Jurnal Kedokteran Brawijaya Vol 24, No 2 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (75.537 KB) | DOI: 10.21776/ub.jkb.2008.024.02.3

Abstract

Coronary  Heart  Diseases  (CHD)  are  a  serious  health  problem  that  commonly  occur  not  only  in  modern countries, but aslo  in developing countries like  Indonesia. The high cholesterol level in  blood is  a risk factor that  may  cause  CHD  by  atherosclerosis  mecanism.  dietary  fiber  may  be  used  to  prevent  atherosclerosis. Cornmeal and cornmeal-soy are products of corn, that rich in fiber. This research was aimed to study about the  effect  of  cornmeal  and  cornmeal-soy  on  serum  cholesterol  level  of  6-8  mounths  male  wistar  rats.  The subjects  are  25  male  wistar  rats.  These  mice  will  be  provided  into  five  groups.  (1)  gruop  that  given atherogenic  diet  only,  (2)  gruop  that  given  atherogenic  diet  with  cornmeal  3.4  g/day,  (3)  gruop  that  given atherogenic diet with cornmeal 6.8 g/day, (4) gruop that given atherogenic diet with cornmeal-soy 3.6 g/day, (5)  gruop  that  given  atherogenic  diet  with  cornmeal-soy  7.2  g/day.  Data  collecting  include  first  weight,  last weight,  weight  gain,  nutrient  intake,  and  serum  lipid.  Statistic  analysis  that  be  used  is  ANOVA  one  way. Results showed that  wistar rats which given atherogenic diet with cornmeal and cornmeal-soy  had trend to increase  cholesterol  and  LDL  level.  According  to  statistic  analysis,  cholesterol  and  LDL  level  among  groups were not significant (p > 0.05). However wistar rats which given atherogenic with cornmeal and cornmeal-soy in  high  doses,
Pengaruh Konseling Motivational Interviewing terhadap Kepatuhan Minum Obat Penderita Hipertensi Harijanto, Wahjoe; Rudijanto, Achmad; N, Arief Alamsyah
Jurnal Kedokteran Brawijaya Vol 28, No 4 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2015.028.04.16

Abstract

Keberhasilan manajemen hipertensi tergantung pada kepatuhan berobat. Meskipun karyawan dan pensiunan PTPN X (Persero) beserta keluarganya mendapat jaminan perawatan kesehatan seumur hidup yang dijamin oleh perusahaan namun tidak menjamin kepatuhan berobat. Penelitian ini dilakukan untuk menguji efek konseling motivational interviewing terhadap kepatuhan minum obat penderita hipertensi. Penelitian ini menggunakan disain pretest – posttest control group. Kelompok uji mendapat perlakuan konseling motivational interviewing dibandingkan dengan kelompok kontrol yang mendapat leaflet cara hidup sehat dengan hipertensi. Penilaian kepatuhan minum obat menggunakan 8 item Morisky Medication Adherence Scale. Didapatkan 65 sampel dari 81 orang yang dibagi menjadi dua kelompok. Kelompok uji berjumlah 33 orang dan kontrol 32 orang yang mendapatkan informasi dalam bentuk leaflet. Umur rata-rata subjek: 61,09 tahun dan terbanyak menderita hipertensi lebih dari lima tahun (56,9%). Hasil penilaian pra intervensi tidak didapatkan perbedaan yang signifikan antara dua kelompok. Hasil pasca intervesi terdapat perbedaan nilai MMAS-8 antara kedua kelompok tetapi profil tekanan darah tidak berbeda. Terdapat perbedaan kepatuhan maupun profil tekanan darah antara pra dan pasca intervensi pada kedua kelompok, kecuali tekanan diastole pada kelompok uji. Motivational interviewing memberikan pengaruh yang positif terhadap peningkatan kepatuhan minum obat penderita hipertensi dan meningkatkan jumlah pasien yang berhasil mencapai target tekanan darah. Kata Kunci: Hipertensi, kepatuhan, konseling, motivational interviewing
Differences in Carotid Intima-Media Thickness (CIMT) In Patients With Newly Diagnosed Hypertension, and Chronic Hypertensive Patients Treated by Calcium Channel Blockers (CCB) or Angiotensin Converting Enzyme (ACE)-Inhibitors Tantri, Ni Luh; Rudijanto, Achmad; Samsu, Nur; Wursito, Wursito
Clinical and Research Journal in Internal Medicine Vol 1, No 1 (2020): New: The First Volume of Clinical and Research Journal in Internal Medicine
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.01.2

Abstract

 Hypertension is a significant risk factor for cardiovascular diseases. It closely related to the inflammatory process and resulting in chronic inflammation, which had a critical role in the progression of atherosclerosis. Carotid Intima-Media Thickness (CIMT) was known as a surrogate marker of atherosclerosis. Anti-hypertensive drugs are expected to affect CIMT. Aim: to examine the difference CIMT between newly diagnosed hypertension and chronic hypertensive treated by ACE-I or CCB. Method: this cross-sectional study was conducted on 12 newly diagnosed hypertensive patients (control or group 1), 9 hypertensive patients treated by CCB (group 2), and 9 hypertensive patients treated by ACE-I (group 3). Their hypertensive condition was controlled at least for 6 months. We compared CIMT of patients and Tumour Necrosis Factor Alfa (TNF-α) also Interleukin-6 (IL-6) among the groups. Result: there was a significant difference in CIMT between the group 1 and 2 (0.86 vs 0.70; p = 0.027), group 1 and 3 (0.86 vs 0.69; p = 0.018). There was no significant difference between group 2 and 3 (0.70 vs 0.69; p = 0.88). There was no association between CIMT and TNF-α, IL-6, Low-Density Lipoprotein (LDL), triglycerides (TGs) levels, and body mass index (BMI), systolic blood pressure. Conclusion: we found that the CIMT of the control group was thicker than those of the treatment groups. Moreover, differences in the thickness of CIMT of the three groups were not associsted with level of TNF-α, IL-6, TG, and LDL, also BMI, and systolic blood pressure.
Comparison of Diagnostic Value between Point of Care Testing (POCT) and Standardize HbA1c Testing in Primary Health Care Rudijanto, Achmad; Rosandi, Rulli; Sasiarini, Laksmi
Clinical and Research Journal in Internal Medicine Vol 1, No 2 (2020): New: The Second Issue is Coming!
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.02.2

Abstract

Diabetes Mellitus is one of the biggest health problems. HbA1c is used to diagnose, to monitor treatment and treatment adjustment. High Performance Liquid Chromatography (HPLC) and electron spray mass spectrometry are recommended to measure HbA1c. But both methods need expensive cost, facility, and potentially increase health cost burden. HbA1c measurement using Point of Care Testing (POCT) is developed in Indonesia. POCT is more comfortable, has lower cost and easily brought to primary health care. Aim: to assess the clinical efficacy of POCT compared with a standard examination by HPLC. Methods: It is a cross-sectional observational study conducted at a first-level health facility (FKTP) in Malang. The subject population was patients who went to an outpatient unit in FKTP with inclusion criteria aged 20-75 years, were participants in the chronic disease management program (PROLANIS), both diabetes and non-diabetes. Results: Three hundred and thirty eight subjects were participated in this study. Five subjects were excluded because the presence of anemia. We used Wilcoxon test to compare HbA1c level between two methods and Rank Spearman correlation test to find correlation between two methods. This study showed measurement HbA1c level using POCT method had good accuracy (>80%). Other than diagnosis value, increased utilization of POCT HbA1c might also be caused by its portability and patient’s comfort. Conclusions: This study showed a strong correlation (R=0.016) between POCT HbA1c and standardized measurement. POCT HbA1c also showed good accuracy in all HbA1c groups.
The Additive Effect of Rosmarinic Acid for The Reduction of Glomerular NF-kB Expression in Diabetes Rat that was given Telmisartan Fachrureza, Mochamad; Samsu, Nur; Rudijanto, Achmad
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

Introduction. Diabetic nephropathy is one of the common complications of diabetes, which one of its causes is the increase of free radicals through the activation of NF-kβ and Angiotensin II. Rosmarinic acid has the activity as the anti-oxidant and anti-inflammatory, and the telmisartan is the partial PPAR-γ agonist that has the anti-fibrotic effect. This study aimed to identify the effect of rosmarinic acid and telmisartan in the reduction of subunit p65 NF-kB expression on the glomerular diabetes rat. Methods. An experimental study with a post-test only controlled group was conducted in a group of rats (Rattus norvegicus). Rats were randomly divided into five groups (n=3-4 per group): three treatment groups (group 1: rosmarinic acid 75 mg/kg/ day; group 2: telmisartan 1 mg/kg/day, group 3: combination of rosmarinic acid 75 mg/kg/day and telmisartan 1mg/kg/ day per day), and two control groups (negative and positive control group). After eight weeks, rats were dissected. Blood sugar more than 270 mg/dl confirmed that the rats in diabetes state. The measurement of albuminuria was done using ELISA and the expression of subunit p65 NF-kβ using the immunofluorescence method. Results. The expression of subunit p65 NF-kβ in negative control group was 519.70 (SD 158.12), 702.19 (SD 189.69) in positive control group, 631.19 (SD 119.21) in the rosmarinic acid group, 355.68 (SD 44.71) in the telmisartan group, and 572.37 (SD 98.09) in the combination group (p<0.001). The post hoc test showed that the mean value of subunit p65 NF-kβ expression was significantly different between the positive control group and the telmisartan group (p<0.001). But, there was no significant mean difference of subunit p65 NF-kβ expression between the positive control group and the rosmarinic acid group (p=1.000), as well as between the combination rosmarinic acid and telmisartan group. Conclusion. The addition of telmisartan can reduce expression of the subunit p65 NF-kB. However, adding the rosmarinic acid in diabetes rats given telmisartan did not reduce the expression of subunit p65 NF-kB in the same level with the negative control group.
Co-Authors Arief Alamsyah N, Arief Alamsyah Em Yunir, Em Ema Pristi Yunita, Ema Pristi Fachrureza, Mochamad Handono Kalim Kumala, Poppy Kusworini Handono Leny Budhi Harti Mandang, Veny VV Nasution, Annio Indah Lestari Ni Luh Tantri Nur Samsu Puteri, Happy HS Rulli Rosandi Saraswati, Made R Sasiarini, Laksmi Tri Yudani Mardining Raras VALENTINA YURINA Wahjoe Harijanto Wardhana wardhana Wursito, Wursito