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All Journal journal of internal medicine CRJIM (Clinical and Research Journal in Internal Medicine)
Ni Luh Tantri
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Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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KORELASI LAJU FILTRASI GLOMERULUS, HEMOGLOBIN, SATURASI OKSIGEN DAN KOMORBID DENGAN KADAR LAKTAT PASIEN PENYAKIT GINJAL KRONIS STADIUM TERMINAL Tantri, Ni Luh; Lahmadi, Iqbal; W Soeatmadji, Djoko; -, Nursamsu
journal of internal medicine Vol. 12, No. 3 September 2011
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.657 KB)

Abstract

Hyperlactatemia usually happen in Chronic Kidney Disease (CKD) patients and it can used as indicator how bad theoxygen perfusion to organs. Therapy for hyperlactatemia is Hemodialysis (HD). Some studies assume few factors thatcorrelate to the level of lactate post HD, such as improving of Glomerulus Filtration Rate (GFR), level of hemoglobin(Hb), oxygen saturation and accompany diseases. An analytic cross sectional study was carried out in Saiful AnwarHospital to deÞ ne correlation between GFR, level of Hb, oxygen saturation and accompany diseases with level of lactatepost HD. Forty three samples were included. There were signiÞ cant correlation between level of lactate post HD withlevel of Hb (p = 0.000) and GFR (p = 0.006). With multivariate models, there were signiÞ cant correlation between levelof lactate post HD with those factors (p = 0.000). Using linier regression entering those variables into model, it foundformula level of lactate = 3.719 ! 0.196 (Hb) ! 0.053 (GFR). There was signiÞ cant correlation between between level oflactate post HD with GFR, Hb, oxygen saturation and accompany diseases.
Differences in Carotid Intima-Media Thickness (CIMT) In Patients With Newly Diagnosed Hypertension, and Chronic Hypertensive Patients Treated by Calcium Channel Blockers (CCB) or Angiotensin Converting Enzyme (ACE)-Inhibitors Tantri, Ni Luh; Rudijanto, Achmad; Samsu, Nur; Wursito, Wursito
Clinical and Research Journal in Internal Medicine Vol 1, No 1 (2020): New: The First Volume of Clinical and Research Journal in Internal Medicine
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.01.2

Abstract

 Hypertension is a significant risk factor for cardiovascular diseases. It closely related to the inflammatory process and resulting in chronic inflammation, which had a critical role in the progression of atherosclerosis. Carotid Intima-Media Thickness (CIMT) was known as a surrogate marker of atherosclerosis. Anti-hypertensive drugs are expected to affect CIMT. Aim: to examine the difference CIMT between newly diagnosed hypertension and chronic hypertensive treated by ACE-I or CCB. Method: this cross-sectional study was conducted on 12 newly diagnosed hypertensive patients (control or group 1), 9 hypertensive patients treated by CCB (group 2), and 9 hypertensive patients treated by ACE-I (group 3). Their hypertensive condition was controlled at least for 6 months. We compared CIMT of patients and Tumour Necrosis Factor Alfa (TNF-α) also Interleukin-6 (IL-6) among the groups. Result: there was a significant difference in CIMT between the group 1 and 2 (0.86 vs 0.70; p = 0.027), group 1 and 3 (0.86 vs 0.69; p = 0.018). There was no significant difference between group 2 and 3 (0.70 vs 0.69; p = 0.88). There was no association between CIMT and TNF-α, IL-6, Low-Density Lipoprotein (LDL), triglycerides (TGs) levels, and body mass index (BMI), systolic blood pressure. Conclusion: we found that the CIMT of the control group was thicker than those of the treatment groups. Moreover, differences in the thickness of CIMT of the three groups were not associsted with level of TNF-α, IL-6, TG, and LDL, also BMI, and systolic blood pressure.
Co-Authors Achmad Rudijanto Djoko W Soeatmadji Iqbal Lahmadi Nur Samsu Nursamsu - Wursito, Wursito