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All Journal JURNAL ILMU KEFARMASIAN INDONESIA International Journal of Science Technology and Health
SITTI HADIJAH SABARWATI
UNIVERSITAS HALU OLEO
Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Medicine & Pharmacology Public Health

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Isolasi dan Identifikasi Senyawa (-)-Asam Usnat dari Lichen Usnea sp. serta Aktivitas Sitotoksiknya terhadap Sel Murine Leukemia P388 MAULIDIYAH MAULIDIYAH; THAMRIN AZIS; SITTI HADIJAH SABARWATI; MUHAMMAD NURDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Lichen is a symbiotic organism composed by algae and fungi that already known produces spesific secondary metabolites having bioactivities. The aim of this study were to isolate and determine the structure of secondary metabolites of Lichen Usnea sp. and to examine the cytotoxic activity against murine leukemia P388 cells. Isolation was carried out by utilizing colom chromatography using silica gel 60 stationary phase with eluent mixtures of n-hexane and ethyl acetate in a gradient elution. Isolates compounds were identified using UV-Vis spectroscopy, IR, 1H-NMR and 13C-NMR. The identification result obtained was (-)-usnic acid compound with molecular weight (MW) of 344 g/mol, needle-shaped yellow crystals. Test results cytotoxic compound of (-)-usnic acid against murine leukemia P388 cells were derived IC50 5.738 ± 0.61 µg/mL.
Microwave Assisted Extraction of Banana Stem Waste and its Antifungal Activity against Fusarium Oxysporum Mashuni Mashuni; muhammad Natsir; Sudirman Sudirman; Sitti Hadijah Sabarwati; Fitri Handayani Hamid; M. Jahiding
International Journal of Science Technology and Health Vol 1 No 1 (2023): Science Technology and Health
Publisher : LPPM ISTEK 'Aisyiyah Kendari

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Banana stem (BS) waste is obtained in large quantities in banana production. In this work, microwave extraction (MAE) from BS was used, and the solvent concentration parameters were 50%, 60%, 70%, 80%, 96% (v/v) ethanol, and 5% HCl with a sample weight of 10 g each. The influence of solvent, time, temperature, and solid: the liquid ratio was evaluated on the extraction results. Total phenolic content (TPC) and its functional performance against Fusarium oxysporum. The effect of a high ethanol concentration on BS extraction was observed because the higher ethanol solvent concentration resulted in higher extraction results and TPC. Optimal MAE conditions were determined at 200 watts for 20 minutes, with 80% ethanol showing better TPC results than other ethanol concentrations, namely 0.7171 mg g-1. The results of chemical content analysis using gas chromatography–mass spectrometry (GC-MS) of BS extract of 80% ethanol obtained phenolic compounds, carboxylic acids, aldehydes, esters, ketones, and furans. BS extract of 80% ethanol showed antifungal activity of Fusarium oxysporum with an apparent zone diameter of 9.7 mm (moderate category). It can be concluded that MAE is an efficient technique for releasing bioactive molecules from BS with TPC and antifungal applications in the agricultural industry.
Microwave-assisted extraction of Phenolic Compounds from Pineapple Peel against Staphylococcus aureus and Escherichia coli Mashuni Mashuni; Fitri Handayani Hamid; M Jahiding; Nur Cahya Islamiati MR; Sitti Hadijah Sabarwati; Andi Muhammad Naufal Khaeri
International Journal of Science Technology and Health Vol 2 No 1 (2024): Science, Technology and Health
Publisher : LPPM ISTEK 'Aisyiyah Kendari

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Pineapple production is mostly marketed as a processed product, resulting in large amounts of industrial waste consisting of pineapple peel, core and crown. This study evaluated organic solvents for microwave-assisted extraction (MAE) of phenolic compounds from pineapple peel and their total phenolic content and antibacterial activities. The application of microwave technology in phenolic extraction provides a fast extraction process and produces higher yields. In addition, organic solvent ethanol is considered an environmentally friendly solvent characterized by low toxicity and increased capacity to extract bioactive compounds. The solvent compositions are ethanol (80%), ethanol-HCl (80%-5%), and ethanol-NaOH (80%-5%). A higher phenolic compound was obtained using ethanol-HCl (80%-5%) of 2.68 mg eq GA/g DW. The results of the antibacterial activity test against Staphylococcus aureus was 19.00 mm and Escherichia coli was 19.31 mm. These results indicate that pineapple peel extract from ethanol-HCl solvent can be an effective antibacterial agent.
Co-Authors Andi Muhammad Naufal Khaeri Fitri Handayani Hamid M Jahiding M. Jahiding Mashuni Mashuni MAULIDIYAH MAULIDIYAH Muhammad Natsir Muhammad Nurdin Nur Cahya Islamiati MR Sudirman Sudirman THAMRIN AZIS