Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Jurnal Epidemiologi Kesehatan Komunitas JURNAL ILMU KEFARMASIAN INDONESIA
INGE SUTANTO
UNIVERSITAS INDONESIA
Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Rasio Efektivitas Biaya Obat Antimalaria Kombinasi Artesunat Amodiakuin dan Kombinasi Sulfadoksin Pirimethamin Dalam Terapi Malaria Falsiparum di Sumba DELINA HASAN; ASCOBAT GANI; PURWANTYASTUTI PURWANTYASTUTI; INGE SUTANTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1236.836 KB)

Abstract

Malaria cases continue to increase in Indonesia, and one of the causes is many malaria parasites resistant to antimalarial drugs such as chloroquine and sulfadoxine pyrimethamine. Antimalarial drug combination recommended by the WHO yet widely available. This study aimed to explore alternative antimalarial drugs through examination of drug-effectiveness and cost-effectiveness analysis of antimalarial drug combination artesunate amodiaquine and sulfadoxine pyrimethamine. To assess the effectix eness or antimalarial drug combinations, as many asl64 patients with who meet inclusion and exclusion criteria were divided into 2 groups with 82 patients respectively. First group was given artesunate amodiaquine while the second group was given sulfadoxine pyrimethamine, and observed for 14 to 28 days. Responses to treatment according to the WHO protocol to include clinical response and parasitological response. The cost effectiveness was assessed through the pharmacoeconomic evaluation method. The results showed that fever clearence time and parasites clearence time by the artesunate amodiaquine combination was faster than by sulfadoxine pyrimethamine combination, and the cost effectiveness ratio of artesunate amodiaquine combination was lower than of sulfadoxine pyrimethamine. In conclusion, the antimalarial drug artesunate amodiaquine combination was more effective and more eflicient than the sulfadoxin pyrimethamine combination, and its cost effectiveness ratio was lower than the sulfadoxine pyrimethamine combination (p=0.05).
Recent Findings in Malaria Emergence of Piperaquine-Resistant Plasmodium falciparum Genes in Malaria Endemic Areas of Indonesia: a Literature Review Ayu Nurdiantika Sari; Tri Yunis Miko Wahyono; Ayleen Alicia Kosasih; Yoshida Aussiana Samosir; Rania Rifdah Taufiq; Inge Sutanto
Jurnal Epidemiologi Kesehatan Komunitas Vol 8, No 2 : Agustus 2023
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v8i2.11803

Abstract

Background: In recent years, artemisinin and piperaquine (PPQ) resistance in the Greater Mekong Sub-region alarmed Southeast Asian countries, especially those relying on artemisinin- based combinations as antimalarial drugs. This study aims to review the current status of malaria research and examine the frequencies of piperaquine resistance in Plasmodium falciparum isolates originating from malaria-endemic areas in Indonesia.Methods: We undertook a review to identify empirical data on antimalarial piperaquine-inclusive artemisinin combination therapies (ACT) in Indonesia using studies conducted since 2015. Journal articles were searched using the keywords combination of malaria, piperaquine, Pfcrt, Pfmdr, Pfpm2, and Indonesia. The search was conducted in four databases. Trends in empirical data were summarised in a table and compared with emerging malaria prevalence and conditions in Indonesia.Results: Our study found that dihydroartemisinin-piperaquine (DHA-PPQ) is still effective in most area. Survey of PPQ resistance in regions using DHA-PPQ as the first-line treatment heavily depends on phenotypic tests of the given drug resistance. Molecular surveys exploring polymorphisms of Pfcrt, Pfmdr1, and Pfpm2 were not found.Conclusion: This study supports the use of dihydroartemisinin-piperaquine as the first-line antimalarial drug in malaria endemic areas of Indonesia. Further research examining efficacy is required to monitor piperaquine resistance in Indonesia.
Co-Authors ASCOBAT GANI Ayleen Alicia Kosasih Ayu Nurdiantika Sari Delina Hasan PURWANTYASTUTI PURWANTYASTUTI Rania Rifdah Taufiq Tri Yunis Miko Wahyono Yoshida Aussiana Samosir