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All Journal JURNAL ILMU KEFARMASIAN INDONESIA
Putu Mirah Risata
UNIVERSITAS KATOLIK WIDYA MANDALA
Medicine & Pharmacology

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Efek Gel Putih Telur terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus novergicus) Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Chintya Wandasari; Putu Mirah Risata
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.513 KB) | DOI: 10.35814/jifi.v16i2.532

Abstract

Egg whites traditionally used for the treatment of burns. In this research, egg white was formulated as gel dosage form for easy to use and covered unpleasant odor. The aim of the study was to determined effectivity of egg white in gel dosage form against the healing of superficial partial thickness burns (second degree) on white rats (Rattus novergicus) Wistar strain with parameters were macrophages, fibroblasts, collagen deposit density and wound healing. Research subject were male white rats aged 3 months. Second degree burns on the back of rat with a diameter of 2 cm were made by using a hot coin with temperature 80 ° C for 20 seconds. 18 white rats divided into 3 groups of treatment that is negative control using 0.9% NaCl, positive control using Bioplacenton®, and 40% egg white gel as treatment. Based on the experimental results, white egg gel given topically decreased the number of macrophages and increase the number of fibroblasts, increase the density of collagen deposits and speed up wound healing on second degree burns. White egg gel had significantly difference with negative control of NaCl 0.9% and no significantly difference with Bioplasenton as positive control.
Co-Authors Chintya Wandasari Hamid, Iwan Sahrial Lucia Hendriati Teguh Widodo